369 papers
Cell biology is the study of life at its most fundamental unit: the cell. This field explores how these microscopic building blocks function, communicate, and replicate to sustain living organisms, from the simplest bacteria to complex human tissues. By understanding the machinery inside a cell, scientists unlock secrets about growth, disease, and the very nature of existence itself.
At Gist.Science, we track every new preprint uploaded to bioRxiv within this dynamic category. Our team processes each submission to provide both accessible plain-language explanations and detailed technical summaries, ensuring you can grasp complex discoveries without getting lost in dense jargon. Below are the latest papers in cell biology, offering a fresh look at the inner workings of life as they are shared with the world.
This study reveals that the regulated turnover of clathrin coats, driven by Swa2-mediated assembly and Sla1-mediated stabilization, is essential for controlling coat size and ensuring the timely progression of actin-driven vesicle budding during endocytosis.
This study reveals that the parasitic alveolate *Toxoplasma gondii* utilizes a neofunctionalized RabGAP-fold protein, TBC9, as an atypical RanGAP to drive essential nucleocytoplasmic transport, a mechanism that appears to have replaced the canonical RanGAP across non-ciliate alveolates.
This study reveals that ATG2A-mediated lipid transfer, rather than pre-existing PI3P, activates ATG9A compartments for autophagy initiation by enabling direct ATG8 lipidation and establishing a positive feedback loop that subsequently drives PI3P production.
This study demonstrates that distinct endosome-associated Rab GTPases, specifically Rab5 and Rab11, orchestrate separate developmental events in neural circuit assembly by regulating the spatial distribution and abundance of early endosome sorting and recycling pathways to control cell-surface receptor trafficking.
This study demonstrates that Trisomy 21 impairs the development of enteric neural crest-derived cells and increases Hirschsprung disease risk by causing SOD1-mediated oxidative stress, which downregulates the RET signaling pathway essential for enteric nervous system formation.
This study establishes a practical framework for cell culture research by validating a low-temperature paraformaldehyde vapor sterilization method for 3D-printed FFF components and identifying compatible materials, including necessary post-treatments to ensure biocompatibility.
This study demonstrates that in *C. elegans*, the conserved cofactor DSB-1 (Rec114) has evolutionarily replaced TOPOVIBL to stabilize SPO-11 complex formation and promote its dimerization, thereby ensuring the regulated generation of meiotic DNA double-strand breaks necessary for genomic stability.
This study reveals that the non-pathogenic model *Naegleria gruberi* exhibits confinement-seeking behavior and persistent, rapid, bleb-based motility within narrow channels and 3D matrices, suggesting these traits are evolutionary adaptations that prime the pathogenic *Naegleria fowleri* for its deadly migration into the human brain.
This study reveals that the Anaphase Promoting Complex (APC) targets the toxic protein progerin for degradation via an autophagy-dependent, proteasome-independent pathway, offering a novel mechanism for reversing Hutchinson-Gilford Progeria Syndrome phenotypes and linking APC function to aging.
This study introduces a DNA barcoding-based paired daughter cell assay to demonstrate that hematopoietic stem cell divisions are biased toward symmetric outcomes (stem-stem or progenitor-progenitor) and reveals a continuum of HSC states linking these division patterns to specific molecular signatures.