Optimizing Complex Health Intervention Packages through the Learn-As-you-GO (LAGO) Design
Dieses Paper stellt das Learn-As-you-GO (LAGO)-Design vor, einen adaptiven Ansatz zur schrittweisen Optimierung komplexer Gesundheitsinterventionen während der Studie, um die Wirksamkeit zu maximieren und das Risiko des Scheiterns von klinischen Studien zu verringern, wie am Beispiel der BetterBirth-Studie und weiterer laufender Projekte demonstriert wird.
Donna Spiegelman (Center on Methods for Implementation,Prevention Science,,Department of Biostatistics, Yale University), Dong Roman Xu (Southern Medical University Institute for Global Health), Ante Bing (Department of Mathematics,Statistics, Boston University), Guangyu Tong (Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University), Mona Abdo (Center on Methods for Implementation,Prevention Science,,Department of Biostatistics, Yale University), Jingyu Cui (Center on Methods for Implementation,Prevention Science,,Department of Biostatistics, Yale University), Charles Goss (Center for Biostatistics,Data Science, Washington University School of Medicine), John Baptist Kiggundu (Infectious Diseases Research Collaboration), Chris T. Longenecker (Division of Cardiology,Department of Global Health, University of Washington), LaRon Nelson (Yale School of Nursing, Yale University), Drew Cameron (Department of Health Policy,Management, Yale University), Fred Semitala (Infectious Diseases Research Collaboration,,Department of Medicine, Makerere University,,Makerere University Joint AIDS Program), Xin Zhou (Center on Methods for Implementation,Prevention Science,,Department of Biostatistics, Yale University), Judith J. Lok (Department of Mathematics,Statistics, Boston University)2026-03-09📊 stat