Optimizing Complex Health Intervention Packages through the Learn-As-you-GO (LAGO) Design
Questo articolo presenta il disegno sperimentale Learn-As-you-GO (LAGO), un approccio adattivo che ottimizza i pacchetti di interventi sanitari complessi durante lo svolgimento dello studio per massimizzare l'efficacia e ridurre i costi, dimostrando come tale metodologia avrebbe potuto prevenire il fallimento dello studio BetterBirth e applicandola a nuove sperimentazioni su HIV e malattie non trasmissibili.
Donna Spiegelman (Center on Methods for Implementation,Prevention Science,,Department of Biostatistics, Yale University), Dong Roman Xu (Southern Medical University Institute for Global Health), Ante Bing (Department of Mathematics,Statistics, Boston University), Guangyu Tong (Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University), Mona Abdo (Center on Methods for Implementation,Prevention Science,,Department of Biostatistics, Yale University), Jingyu Cui (Center on Methods for Implementation,Prevention Science,,Department of Biostatistics, Yale University), Charles Goss (Center for Biostatistics,Data Science, Washington University School of Medicine), John Baptist Kiggundu (Infectious Diseases Research Collaboration), Chris T. Longenecker (Division of Cardiology,Department of Global Health, University of Washington), LaRon Nelson (Yale School of Nursing, Yale University), Drew Cameron (Department of Health Policy,Management, Yale University), Fred Semitala (Infectious Diseases Research Collaboration,,Department of Medicine, Makerere University,,Makerere University Joint AIDS Program), Xin Zhou (Center on Methods for Implementation,Prevention Science,,Department of Biostatistics, Yale University), Judith J. Lok (Department of Mathematics,Statistics, Boston University)2026-03-09📊 stat