📄 medicine

Pre-Operative Microbiome Signatures as Independent Predictors of Aggressive Prostate Cancer Phenotypes

这项前瞻性队列研究表明,术前微生物组特征,特别是粪肠球菌(*Enterococcus faecalis*)与肺炎克雷伯菌(*Klebsiella pneumoniae*)的共同定植,是侵袭性前列腺癌表型的独立预测因子,并且在超越前列腺特异性抗原(PSA)等传统临床指标方面显著提高了风险分层能力。

Pavlov Valentin Nikolaevich, Samuel Olalekan Akinyemi, VICTOR OLAMIPOSI OLAIYA, Urmantsev Marat Fayazovich, Tuguzbaeva G (…)2026-07-10
📄 medicine

The Mediating Role of Object Relations Quality and Defense Mechanisms in the relationship between ICD-11 Five-Factor Personality Traits and Current Suicidal Ideation in Major Depressive Disorder

这项针对386名重度抑郁障碍门诊患者的研究表明,虽然特定的ICD-11人格特质直接影响自杀意念,但客体关系质量和防御机制起到了显著的中介作用,凸显了在治疗干预中针对这些心理动力学结构进行干预的重要性。

Matin Khanpayeh, Kaveh Qaderi Bagajan, Soheib Amini, Kiyana Mardani, Bita zardar, Bakhtiar Piroozi2026-07-10
📄 medicine

Hemodynamic and ventilation/perfusion effects of continuous anterior chest compression in acute respiratory distress syndrome

在患有中重度ARDS的患者中,持续性前胸压缩可改善那些因过度扩张而导致平台压出现矛盾性下降的患者的右心室功能并降低后负荷,而在无反应者中则会通过增加分流来恶化通气/血流匹配。

Pascale Labedade, Samuel Tuffet, Paul Masi, Elsa Moncomble, Mohamed Boujelben, Anne-Fleur Haudebourg, François Bagate, A (…)2026-07-10
📄 medicine

Recurrent stroke following left atrial appendage closure in patients with ischemic stroke under oral anticoagulation: a systematic review and meta-analysis

这项针对 1,091 名既往在口服抗凝治疗下仍发生缺血性卒中高风险老年患者的系统评价和荟萃分析发现,左心耳封堵术与 3.1% 的残余年度缺血性卒中复发率相关,凸显了开展前瞻性试验以优化术后抗血栓策略的必要性。

Tommaso Bini, Marco Gamardella, Antanas Gasys, Roberto Galea, Laurent Roten, David Seiffge, Lorenz Räber, George CM Sion (…)2026-07-10
📄 medicine

Antibody-drug conjugates for advanced/recurrent high-grade endometrial cancer: potential targets, strategies and challenges

本综述通过总结抗体偶联药物(ADCs)目前的临床应用、临床前证据及早期临床试验结果,探讨了其作为晚期或复发性高级别子宫内膜癌治疗选择的新兴作用,同时也讨论了耐药机制以及克服这些挑战的未来课题。

Yusuke Matoba, Esther Rodman, Maryam Azimi Mohammadabadi, Sara Bouberhan, Oladapo Yeku, Bo Rueda2026-07-10
📄 medicine

Health in All Policies: The Impact of the Healthy City Pilot Policy on Cognitive Health and Cognitive Health Inequality Among Older Adults in China—Evidence from Difference-in-Differences and Double Machine Learning

本研究表明,中国的健康城市试点政策通过改善生活环境、健康行为、社会参与和数字包容性,显著提升了老年人的认知健康并降低了认知健康不平等,且其效果在不同的人口统计特征和地区群体中存在差异。

Jialin Xu, Longyi Huang, Qianwen Sun, Yang Luo, zixuan JiaoYang, Aijun Xu, Zhi Liu, Xuebin Qiao2026-07-10
📄 medicine

Selective versus complete caries removal in deep posterior lesions: a six-month prospective pilot

这项关于深部后牙病损中选择性去除与完全去除进行的为期六个月的前瞻性试点研究发现,尽管在双侧检验中差异未达到统计学显著性,但选择性去除显示出比完全去除在临床上具有相关性的、数值更高的成功率和牙髓敏感性,这凸显了开展更大规模、更长期试验的必要性。

Ana Iglesias Poveda2026-07-10
📄 medicine

Neuromuscular electrical stimulation versus combined aerobic and resistance exercise versus health literacy intervention for glycemic control in institutionalized older adults with type 2 diabetes: study protocol for a randomized controlled trial

本研究方案概述了一项三臂随机对照试验,旨在比较神经肌肉电刺激、监督下的有氧与抗阻联合运动以及健康素养教育在为期12周的时间内,对机构养老型2型糖尿病老年患者血糖控制及次要结局的影响。

Carlos Tavares, Rui Soles Gonçalves, Rocío Llamas-Ramos2026-07-10
📄 medicine

Tirzepatide Attenuates Diabetes-Associated Testicular Inflammation and Sperm DNA Fragmentation in Obese Diabetic Mice: Potential Pleiotropic Effects Beyond Glycemic Control

本研究表明,替泽帕肽通过睾丸巨噬细胞中的 GIPR 介导机制,改善了肥胖糖尿病小鼠的糖尿病诱导性睾丸炎症、氧化应激和精子 DNA 碎片化,从而展现出超越其血糖控制能力的保护作用。

Yusaku Mori, Naoya Osaka, Michishige Terasaki, Hironori Yashima, Tomomi Saito, Daiki Tokado, Madoka Ogino, Makoto Ohara (…)2026-07-10