📄 medicine

Nrf2/HO-1 Signaling Axis Activation Underpins the Endogenous "Rest-Relief" Mechanism in a Rat Model of Lumbar Spinal Stenosis-Induced Neurogenic Intermittent Claudication

本研究表明,在腰椎管狭窄的大鼠模型中,休息时神经源性间歇性跛行的内源性缓解是由Nrf2/HO-1信号轴的激活所驱动的,该轴通过减轻由循环性缺血再灌注引起的氧化应激和神经炎症,提示该通路可作为非手术治疗干预的一个具有前景的靶点。

Daiyuan Liu, Haibao Wen, Minrui Fu, Jinghua Gao, Chunyu Gao, Luguang Li, Jianguo Li, Minshan Feng, Wu Sun2026-07-07
📄 medicine

Impact of imperatorin and isoimperatorin on the pharmacokinetics of abemaciclib both in vivo and in vitro

本研究表明,由于通过竞争 CYP3A4 结合来抑制其代谢,共同给药补骨脂素或异补骨脂素会显著改变乳腺癌药物阿贝西利在鼠体内的药代动力学特征,这提示在联合使用这些药物时需临床谨慎。

Chengfeng Wang, Jianfeng Wang, Zebei Lu, Yu Wang, Abdullah Al Mamun, Md Siddiqul Islam, Shuanghu Wang, Yunfang Zhou, Min (…)2026-07-07
📄 medicine

Beyond the pandemic declaration: Persistent daily health complaints in diabetic COVID-19 survivors and the protective effect of prior vaccination in Indonesian primary care

这项针对印度尼西亚基层医疗机构中 420 名糖尿病新冠肺炎康复者的横断面研究表明,感染前接种疫苗与持续性日常健康投诉减少 45% 相关,凸显了在中低收入国家将疫苗接种推广纳入慢性病管理的重要性。

Putri Bungsu Machmud, Husnul Khatimah, Renti Mahkota, Jessica Veronica, Arie Wahyu Wijayanto2026-07-07
📄 medicine

Multimodal imaging features of intra-parenchymal schwannoma

这项针对22例实质内神经鞘瘤病例的回顾性研究,通过描述该病症独特的多种模态影像学特征——包括具有显著水肿的边界清晰的实性-囊性肿块、异质性对比增强、高灌注、不受限的扩散以及特定的MRS代谢模式——旨在辅助其准确诊断。

Jiaying Gong, Zelan Ma, Yan Deng, Qianwen Guan, Zhongwen Zhou, Shukun Liao, Ke Sun, Na Shen, Donghui Gan, Hanqiu Liu2026-07-07
📄 medicine

Surrogate Decision-Making Confidence Across Acute and General Scenarios: Predictors and Ethical Reasoning in a Mixed-Methods Study

这项混合方法研究表明,代理决策者在急性场景下的信心显著低于一般场景,且自我效能感是两种情境下预测信心的最强指标,这表明通过针对性的准备来提升自我效能感,可能有助于提高决策准备度。

Yuxin Zhao, Onyinye Mbanefo, Sean Lawrence, Nethra Rajeshkumar, Emily Jon, Benjamin Katz, Pamela Teaster2026-07-07
📄 medicine

Determinants of healthy dietary patterns among Iranian adults with type 2 diabetes: evidence from the Stepwise Approach to Noncommunicable Risk Factor Surveillance (STEPS 2021)

这项针对伊朗 2 型糖尿病成年人的横断面研究表明,较高的受教育程度、更丰富的财富、医疗保险覆盖以及不吸烟行为,均与遵循健康饮食模式独立相关。

Fatemeh Sadat Mirtaher, Neda Cheraghloo, Atefeh Amrollahi bioky, Farima Farsi, Sasan Sharghi, Yosra Azizpour, Asieh Mans (…)2026-07-07