📄 medicine

Absence of a Weekend Effect on In-Hospital Mortality in Upper Gastrointestinal Bleeding: A Multisite Study from an Integrated Health System

在一项针对一体化医疗系统中超过7,600名患者的大型回顾性研究中,周末入院治疗上消化道出血与住院死亡率或其他不良预后并无关联,这表明标准化的24/7护理路径有效地消除了该疾病中的“周末效应”。

Ali Sohail, Uday Sankar Akash Vankayala, Bivin George, Jon Javor, Liliane Deeb2026-07-06
📄 medicine

Retatrutide Treatment in Streptozotocin-Induced Diabetic Rats: Renal Inflammatory Cytokines, HIF‑1α Signalling, and Histopathological Injury Profile

本研究表明,虽然雷他鲁肽(Retatutide)治疗在链脲佐菌素诱导的糖尿病大鼠中显著减轻了 HIF-1α 的上调,并呈现出减轻肾脏炎症和组织病理学损伤的非显著趋势,但尚未赋予明显的结构性肾保护作用,这表明需要更长的持续时间或慢性疾病模型来证实其治疗潜力。

Ulya Keskin, Eslem Altın, Fikriye Yasemin Özatik, Ayşe Koçak Sezgin, Ayşe Çakır Gündoğdu, Neziha Senem Arı, Melkan Kağan (…)2026-07-06
📄 medicine

Misconceptions, Stigma, and Mpox Prevention and Control Practices in Sierra Leone: A Cross-Sectional Study

这项针对塞拉利昂6,096名参与者的横断面研究表明,尽管关于猴痘的误解(例如将其视为天谴或政府宣传)显著削弱了预防和控制措施,但污名化并不会独立影响这些行为,这凸显了开展针对性风险沟通以解决错误观念的必要性。

Mohamed Boie Jalloh, Abdulai Alpha Jalloh, James Sylvester Squire, Ibrahim Kamara, Daam Koeloengan Clement, Mosoka Papa (…)2026-07-06
📄 medicine

Integrated Multi-Cohort Transcriptomic Meta-Analysis and Molecular Docking Identify Core Dysregulated Hub Pathways and Therapeutic Ligands in Parkinson’s Disease

本研究整合多队列转录组荟萃分析与分子对接技术,旨在将 DRD2 和 SLC18A3 鉴定为一种新型帕金森病诊断模型的核心枢纽基因,并提出多奈哌齐和溴隐亭作为靶向焦亡及神经炎症通路潜力的治疗配体。

Fatima Tariq, Ezza Abbas, Zainab Ashraf, Fatima Munir, Usama Munir, Rida Amjad2026-07-06
📄 medicine

Trauma and Its Associated Factors in Patients Presenting at the Emergency Department, Intermediate Hospital, Oshakati, Namibia: Epidemiological Baseline and Implications for Contemporary Trauma Care Systems

本研究证实,在纳米比亚奥沙卡蒂中级医院,创伤病例占急诊就诊量的20%以上,且不成比例地影响了年轻失业男性,其中饮酒被确定为驱动暴力和事故的关键可干预风险因素,从而凸显了加强创伤护理系统和开展针对性预防策略的紧迫性。

Lorenta Ojo2026-07-06
📄 medicine

Perioperative Considerations and Outcomes of the Hybrid Convergent Procedure for Atrial Fibrillation: A Prospective Observational Study

这项前瞻性观察性研究表明,尽管早期术后心包炎和心律失常较为常见,但用于治疗心房颤动的高级混合收敛术具有良好的围术期特征,其主要并发症发生率低且重症监护室停留时间短,同时在大多数患者中实现了显著的长期节律控制。

Bradley Wibrow, Pragnesh Joshi, Rukshen Weerasooriya, Remy Spring, Patrick McCormick, Kieran Blake, Lahni Campbell, Matt (…)2026-07-06
📄 medicine

Occupational Sharps Injuries Among Healthcare Workers in Sub-Saharan Africa: Safety Practices, Risk Factors, and Professional Disparities at a Namibian Referral Hospital

一项2020年针对纳米比亚一家转诊医院进行的横断面研究显示,超过一半的医护人员曾发生过锐器伤,其中医生报告的受伤频率更高且安全合规性低于护士,这凸显了除了单纯的意识提升之外,对针对性机构干预和改进工作场所安全系统的紧迫需求。

Lorenta Ojo, Martha Chadyiwa2026-07-06
📄 medicine

Anterior to Psoas Corridor, Does It Really Exist?! An MRI Analysis

这项 MRI 研究表明,从 L1 到 L5,斜向腰椎间融合术的前方至腰大肌通道逐渐变窄,且通过右侧卧位可得到适度加宽,这表明在手术体位下进行术前影像学检查对于确定安全的器械尺寸以及评估是否需要进行腰大肌牵引至关重要。

Thiago Coutinho, Carlos Tucci, Alexandre Cristante Fogaça, Raphael Martus Macron, Tacísio Eloy Pessoa de Barros Filho, M (…)2026-07-06