📄 medicine

Two-Year Functional Outcomes of Kinematic Versus Mechanical Alignment in Primary Total Knee Arthroplasty: A Single-Surgeon Propensity-Matched Study in an Asian Population

在一项针对亚洲人群的倾向评分匹配研究中,在初次全膝关节置换术中,解剖学对线与机械对线相比,展现出了相当或更优的两年期功能结果和患者满意度,且具有等效的安全性和无复审生存率。

Bo Xiang Bryan Neo, Vishwajit Vijay Patil, Keng-Jin Darren Tay, Hee-Nee Pang, Seng-Jin Yeo, Ming Han Lincoln Liow2026-07-03
📄 medicine

Evaluation of Microplastic Density in Bronchoalveolar Lavage Fluid of Newly Diagnosed Lung Cancer Patients: A Prospective Observational Controlled Study

这项前瞻性观察研究发现,尽管微塑料普遍存在于新诊断肺癌患者和对照组的支气管肺泡灌洗液中,但两组之间的密度相当,这表明这些颗粒反映的是普遍的环境吸入,而非作为恶性肿瘤的特异性指标。

Nalan Ogan, Aysegul Tuna, Murat Koc, Ipek Candemir, Ersin Gunay2026-07-03
📄 medicine

Acute kidney injury risk with SGLT2 inhibitors versus sulfonylureas by baseline cardiorenal status in type 2 diabetes: A nationwide cohort study

在一项大规模全韩全国性队列研究中,将 SGLT2 抑制剂作为 2 型糖尿病的二线治疗方案,与较磺脲类药物显著降低的 180 天急性肾损伤风险相关,这种保护作用在心力衰竭患者中持续存在,但在患有预存慢性肾脏病的患者中有所减弱。

Eonji Na, Hyeri Yang, Bonggi Kim, Sungho Won2026-07-03
📄 medicine

Perioperative Hemodynamic Disturbance as a Mediator Between Preoperative Pulmonary Hypertension and Acute Kidney Injury After Cardiopulmonary Bypass-assisted Cardiac Surgery: A Retrospective Cohort Study

这项针对2,242例心脏手术患者的回顾性队列研究表明,术后血管收缩药物-强心剂的需求量以及术中低血压是连接术前肺动脉高压与急性肾损伤风险增加的重要且部分可干预的中介因素。

Zhou Zhou, Jinyi Shi, Wanxia Li, Rui Ding, Xuanyu Luan, Xinlong Zhang, Yang Zhang, Jiaxin Ren, Shiting Chen, Jialin Yin (…)2026-07-03
📄 medicine

Serum Lipid Biomarkers and Their Associations with Age-Related Macular Degeneration: A Cross-Sectional Analysis from the Beichen Eye Study

这项针对北辰眼科研究中4,748名50岁以上参与者的横断面分析发现,较高的甘油三酯与高密度脂蛋白胆固醇比值以及较低的甘油三酯水平与年龄相关性黄斑变性的患病率降低相关,而高密度脂蛋白胆固醇本身则未显示出独立的关联性。

Gang Zou, Fei Gao, Limin Zhang, Xiaorong Li2026-07-03
📄 medicine

Deep Learning-Based Whole-Body Lesion Segmentation and Automated OMIS Computation on [68Ga]Ga-DOTA-TOC PET/CT: Technical Feasibility of a SwinUNETR Pipeline for Pre-PRRT Bone Marrow Involvement Scoring

本研究证明了基于 SwinUNETR 的深度学习流水线在 [68Ga]Ga-DOTA-TOC PET/CT 上进行全身体灶分割及骨髓侵犯评分(OMIS)计算的技术可行性,其性能可与专家观察者间一致性相媲美,并为神经内分泌肿瘤患者的 PRRT 前风险分层提供了一种具有可重复性的工具。

Romain Ferrara, Solène Malmon, Salim Kanoun, Joris Cocquebert, Thibaut Reichert, Adil Moussali, Nathalie Charrier, Sébas (…)2026-07-03
📄 medicine

Successful Reversal of Tachycardia Induced Cardiomyopathy After Flecainide Therapy in an Infant With Focal Atrial Tachycardia

本病例报告描述了一例通过及时启动氟卡尼定治疗,成功逆转一名患有局灶性房性心动过速的4.5个月大婴儿心动过速性心肌病的过程,该治疗恢复了窦性心律,并在初始频率控制策略失败后,使患者的心室功能和临床状态完全恢复。

Arife Sancaktar, Tuğba Burcu Öztürk Gömeç, İrem Ersayoğlu2026-07-03
📄 medicine

Development and Internal Validation of a Simple Four-Variable Model for Predicting High-Risk Varices in Patients with Virally Suppressed HBV-Related Cirrhosis

本研究开发并内部验证了一个包含白蛋白、丙氨酸氨基转移酶、凝血酶原时间活性和脾肿大的简单四变量模型,该模型在预测病毒抑制状态下 HBV 相关肝硬化患者的高风险食管胃底静脉曲张方面,较之现有的无创评分显示出更优越的预测准确性。

Xu Huang, Shaofei Wu, Wenhua Liu, Hao Zhuo, Ziheng Zhang, Yong An, Liwei Guo2026-07-03