📄 medicine

Development and Transportability Assessment of a Parsimonious Machine Learning Model for Predicting In-Hospital Mortality in ICU Patients with Cirrhosis and Sepsis: A MIMIC-IV and Chinese Cohort Study

本研究开发并验证了一个利用早期 ICU 数据来预测肝硬化合并脓毒症患者院内死亡率的可解释、简约机器学习模型,并证明了该模型在 MIMIC-IV 和中国队列中的有效性与可迁移性。

Lei-Lei Zhang, Xingcheng Zhang, Li-Li Fang, Xiqun Lei, Luyao Huang, Nanbing Shan2026-07-03
📄 medicine

Comparison of methods between video raster stereography and EOS imaging in the diagnosis of adolescent idiopathic scoliosis

这项针对50例青少年特发性脊柱侧弯患者的前瞻性比较研究发现,尽管视频光栅立体测量术(VRS)与EOS成像具有显著相关性并展现出用于无辐射监测的潜力,但两种方法之间的系统性差异使得VRS目前尚无法取代EOS用于诊断或实现直接的临床互换。

Panagiotis Diaremes, Robert Schneider, Fee Christiane Keil, Rejane Golbach, Gerhard Oremek, David A Groneberg, Elke Hatt (…)2026-07-03
📄 medicine

The Interaction between Vitamin A and Serotonin Exhibits Sexual Dimorphism in the Core Symptoms and Neurodevelopment of Autism Spectrum Disorder: A National Multicenter Study

这项全国多中心研究表明,维生素A缺乏与血清素水平升高之间的相互作用表现出显著的性别二态性,具体表现为调节了患有自闭症谱系障碍的男孩的核心症状和神经发育结局,但在女孩中则不然。

Min Guo, Dan Ai, Qian Zhang, Li Chen, Ying Dai, Hua Wei, Xiao Liu, Feiyong Jia, Yan Hao, Ling Li, Jie Zhang, Lijie Wu, X (…)2026-07-03
📄 medicine

Regression of Hepatic Steatosis After Bariatric Surgery Quantified by the Ultrasound-Guided Attenuation Parameter (UGAP): A Prospective Six-Month Study

这项为期六个月的前瞻性研究表明,减重手术诱导了肝脏脂肪变性的显著早期减轻,该减轻通过超声引导衰减参数(UGAP)进行量化,其变化趋势与体重减轻相平行,尽管在个体患者层面并未显示出与体重指数(BMI)下降存在显著相关性。

Ahmed Sheerali2026-07-03
📄 medicine

A Copper Metabolism-Related Gene Signature Predicts Prognosis and Therapeutic Response in Breast Cancer Based on Multi-Omics Analysis

本研究通过全面的多组学分析和因果推断,建立了一个稳健的四基因铜代谢相关特征谱,该特征谱能有效分层乳腺癌预后、预测免疫治疗和化疗反应,并确定 EVA1B 为潜在的因果治疗靶点。

Weizhong Chen, Tao Chen, Yanfang Chen, Cuicai Lin, Wenhan Chen, Xiaoru Wu, Lusheng Liao, Mingyou Dong, Zhichao Fang2026-07-03
📄 medicine

Baseline Age is Independently Associated With the Rate of Arterial Stiffening Over 7 Years in a Zambian HIV Cohort

在一项针对生活在赞比亚的艾滋病毒感染者的七年纵向研究中,发现基线年龄在50岁或以上与显著更快的动脉硬化速率独立相关,这强调了在常规艾滋病毒护理中进行早期心血管筛查以及血压和体重指数管理的必要性。

Longa Kaluba, Theresa Chikopela, Sepiso K Masenga, Benson M Hamooya, Fastone Goma, Wilbroad Mutale, Katongo H Mutengo2026-07-03