📄 other

Cobalt-Based Drug Delivery to the Brain using Rapid Short-Pulses of Focused Ultrasound and Microbubbles reduces Aβ aggregation in 5XFAD mice

通过重复的快速短脉冲聚焦超声结合微泡技术,安全地将钴基抑制剂 CoLAm2 递送至 5XFAD 小鼠的大脑屏障,在不产生不良行为效应的情况下,实现了淀粉样蛋白-β 斑块聚集量显著减少 60.5%。

Sophie V. Morse, Lucia Rohfleisch, Grainne Geoghegan, Krit Sujarittam, Sarah Rimer, Tiffany G. Chan, Timothy Kench, Mari (…)2026-07-24
📄 other

Distal Limb Closure Versus Non-Closure During Diverting Loop Ileostomy Following Laparoscopic Anterior Resection: A Prospective Non-Randomized Comparative Cohort Study

在一项关于接受腹腔镜前切除术并行造口术的患者的前瞻性非随机队列研究中,机械性关闭远端肠袢与不进行关闭相比,并未显著降低吻合口瘘或其他并发症的发生率,但与较长的住院时间及肠功能恢复延迟相关。

Fakhri Anaraki, Ramin Haddadi, Hamidreza Movahedi, Saina Ghadiany, Behrooz Mehraneh Rudi, Adel Zeinalpour2026-07-24
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Predictive ecological niche models using Open Access-‘BIG DATA’ quantify anthropogenic influence: Overlapping common (Panthera pardus), snow leopard (P. uncia) and prey species in Central Himalaya

本研究利用开放获取的大数据和机器学习集成方法,量化了尼泊尔高里尚卡保护区内豹、雪豹及其猎物的生境适宜性与生态位重叠受到的人为影响,揭示了显著的人为诱发空间重叠,从而为有针对性的全球保护策略提供依据。

Purna Bahadur Ale, Falk Huettmann, Morten Odden, Madhu Chetri2026-07-24
📄 other

Bending Moment Synthesis by Integrating Cutting Mechanics with Diffusion Model for Tool Wear Prediction​

本研究提出了一种新型刀具磨损预测框架,该框架通过特征线性调制(Feature-wise Linear Modulation)将机理切削弯矩模型与扩散模型相结合,以生成物理一致的合成信号,从而在显著提高未知条件下预测准确性的同时,大幅减少了对大量实际训练数据的需求。

Yu-Sheng Lin, Jian-Ping Jhuang, Meng-Shiun Tsai2026-07-24
📄 other

Retrospective Evaluation of the Effects of Ureteral Double-J Stent Placement Versus Percutaneous Nephrostomy on Renal Function and Quality of Life in Patients with Unilateral Acute Obstructive Hydronephrosis Without Renal Failure

这项回顾性研究表明,虽然双J管置入术和经皮肾造瘘术都能有效缓解单侧急性梗阻性肾积水并具有相当的肾功能预后,但双J管置入术在疼痛控制和健康相关生活质量改善方面表现更优。

Kubilay Sabuncu, Bilal Eryildirim, Kemal Sarica2026-07-24
📄 other

Characterization and functional evaluation of laccase-catalyzed synthesis of quercetin and caffeic acid derivatives

本研究表明,云芝漆酶(Trametes versicolor laccase)能够在温和条件下高效地对槲皮素和咖啡酸进行共转化,从而生成具有更高水溶性且保留细胞毒性的新型酚类衍生物,为克服这些化合物的局限性提供了一种可持续策略。

Karla Verónica Teymennet-Ramírez, Leticia Casas-Godoy Casas-Godoy, Neith Aracely Pacheco-López, Ivan Emanuel Herrera-Poo (…)2026-07-24