Single-cell and spatial transcriptomic profiling of primary versus recurrent glioblastoma identifies PLOD2 as a core orchestrator of hypoxic niche remodeling and mesenchymal transition
本研究整合了多组学分析,旨在将 PLOD2 鉴定为驱动胶质母细胞瘤复发的关键因子,该因子通过 PLOD2/LAMA4 轴编排缺氧微环境重构和间质转化,从而促进治疗耐药,并提供了一个潜在的治疗靶点。