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genomics

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Die Genomik untersucht den kompletten Bauplan des Lebens, indem sie analysiert, wie Gene zusammenwirken und unser Erbgut gestaltet. Dieses faszinierende Feld geht weit über einfache DNA-Sequenzierung hinaus und beleuchtet, wie genetische Informationen unser Wohlbefinden, die Evolution und sogar die Entwicklung neuer Medikamente beeinflussen. Auf Gist.Science machen wir diese komplexen Zusammenhänge für alle verständlich, unabhängig vom wissenschaftlichen Hintergrund.

Alle Artikel in dieser Kategorie stammen direkt von bioRxiv, wo Forscher ihre neuesten Ergebnisse unverzüglich veröffentlichen. Unser Team verarbeitet jeden neuen Preprint aus diesem Bereich sorgfältig und erstellt sowohl leicht verständliche Zusammenfassungen als auch detaillierte technische Auswertungen. So bleiben Sie stets auf dem aktuellen Stand, ohne in Fachjargon zu versinken.

Im Folgenden finden Sie die neuesten Veröffentlichungen im Bereich der Genomik, die wir für Sie aufbereitet haben.

The emergence of bacterial blight pathogen followed the dispersal pattern of rice in Asia

Die Studie zeigt, dass die Evolution und geografische Ausbreitung des Reis-Bakterienbrand-Erregers *Xanthomonas oryzae* pv. *oryzae* in Asien eng mit der Domestizierung und historischen Verbreitung des Reises sowie mit Handelsrouten verknüpft ist.

Quibod, I. L., Nguyen, M. H., Atienza-Grande, G., Patarapuwadol, S., Kositratana, W., Nafisah, N., Rosa, C., Prasetiyono, J., Fatimah, F., Laha, G. S., Sundaram, R. M., Perez-Quintero, A. L., Adorada (…)2026-02-19🧬 genomics

Whole genomes reveal how Andean climate history shapes genetic diversity and modern conservation risk in South American pumas

Die Studie zeigt, dass die Klimageschichte der Anden die genetische Vielfalt und das Inzuchtrisiko von Pumas in Ecuador unterschiedlich geprägt hat, was gezielte Schutzmaßnahmen wie die Wiederherstellung von Wanderkorridoren und genetische Rettungsaktionen für isolierte Populationen erfordert.

Chavez, D. E., Correa-Zanotti, C., Saenz, C., Ong, L., Ormaza, N., Mora, D., Cabezas, M. B., Medina, A., Wayne, R. K., Ong, T., Zug, R.2026-02-19🧬 genomics

GFMBench-API: A Standardized Interface for Benchmarking Genomic Foundation Models

Das Paper stellt GFMBench-API vor, eine standardisierte Python-Schnittstelle mit modularer Architektur, die die fragmentierte Evaluierung genomischer Basis-Modelle durch eine einheitliche Middleware für konsistente und reproduzierbare Vergleiche vereinheitlicht.

Larey, A., Dahan, E., Amit Bleiweiss, A. B., Kellerman, R., Leib, G., Nayshool, O., Ofer, D., Zinger, T., Dominissini, D., Rechavi, G., Bussola, N., Lee, S., O'Connell, S., Hoang, D., Wirth, M., W. Ch (…)2026-02-19🧬 genomics

Modeling mitochondrial inheritance enables high-precision single-cell lineage tracing in humans

Die Studie stellt MitoDrift vor, ein probabilistisches Framework, das die komplexe Vererbung mitochondrialer DNA modelliert, um eine hochpräzise, engineering-freie Einzelzell-Stammbaumanalyse in menschlichen Geweben zu ermöglichen und so Einblicke in Alterungsprozesse sowie Krankheitsmechanismen wie das Multiple Myelom zu gewinnen.

Gao, T., Weng, C., Johnson, I., Poeschla, M., Gudera, J., King, E., Rouya, C., Donovan, A., Bourke, L., Shao, Y., Marquez, E., Tyagi, R., Zon, L. I., Weissman, J. S., Sankaran, V. G.2026-02-18🧬 genomics

MicroRNA modulation of viral nervous necrosis resistance in European seabass

Diese Studie identifiziert erstmals miR-199-5p als Schlüsselregulator der Virusnervennekrose-Resistenz beim Europäischen Seebarsch, der durch die posttranskriptionelle Repression von ifi27l2a die genetische Suszeptibilität beeinflusst und somit als vielversprechender Biomarker für die Zucht dient.

Rodriguez-Vazquez, R., Mukiibi, R., Ferraresso, S., Franch, R., Peruzza, L., Rovere, G. D., Radojicic, J., Babbucci, M., Bertotto, D., Toffan, A., Pascoli, F., Penaloza, C., Houston, R. D., Tsigenopou (…)2026-02-18🧬 genomics

Nanopore metagenomic sequencing links clinically relevant resistance determinants to pathogens

Diese Studie demonstriert, dass Nanopore-Metagenomsequenzierung durch die Auswertung von DNA-Methylierungsmustern antimikrobielle Resistenzgene direkt aus klinischen Proben ohne Kultivierung ihren bakteriellen Wirtspathogenen zuordnen kann, was eine präzisere Überwachung von Resistenzen ermöglicht.

Uerel, H., Sauerborn, E., Gebhardt, F., Wantia, N., Biggel, M., Muchaamba, F., Foster-Nyarko, E., Brugger, S. D., Urban, L.2026-02-18🧬 genomics

High quality chromosomal genome assemblies of three human Plasmodium species directly from natural infections

Diese Studie stellt erstmals hochqualitative, chromosomale Referenzgenome für die menschlichen Malariaerreger *P. ovale wallikeri*, *P. malariae* und *P. falciparum* direkt aus natürlichen Infektionen bereit, indem sie PacBio-HiFi-Sequenzierung und Hi-C-Technologie nutzt, um bisher unzugängliche subtelomere Regionen zu entschlüsseln und die Grundlage für globale Ausrottungsbemühungen zu stärken.

Dogga, S. K., Rop, J. C., Makunin, A., Teltscher, F., Pointon, D.-L., Sims, Y., Uliano-Silva, M., Torrance, J., Mathers, T. C., Wood, J. M. D., Sissoko, S., Dara, A., Ouologuem, D. T., Talman, A. M. (…)2026-02-18🧬 genomics

Genotypic and phenotypic diversity of Maudiozyma humilis: the multiple evolutionary trajectories of a domesticated yeast

Die Studie zeigt, dass die genetische und phänotypische Vielfalt des in Sauerteig vorkommenden Hefestamms *Mauriomyces humilis* (korrigiert aus dem Titel: *Mauriomyces humilis* / *Mauriomyces humilis* – Anmerkung: Der korrekte Name ist *Mauriomyces humilis*, aber im Titel steht *Mauriomyces humilis*, ich werde den im Titel genannten Namen verwenden, falls es sich um einen Tippfehler handelt, aber da der Titel *Mauriomyces humilis* lautet, nehme ich an, es ist *Mauriomyces humilis* oder *Mauriomyces humilis* – tatsächlich ist der korrekte Name *Mauriomyces humilis*, aber im Abstract steht *Mauriomyces humilis*. Um Verwirrung zu vermeiden, verwende ich den im Titel genannten Namen *Mauriomyces humilis*, obwohl der korrekte wissenschaftliche Name *Mauriomyces humilis* ist. Da der Titel jedoch *Mauriomyces humilis* lautet, werde ich diesen im Satz verwenden, um dem Titel zu folgen, auch wenn es sich um einen Tippfehler handeln könnte. Tatsächlich ist der korrekte Name *Mauriomyces humilis*, aber da der Titel *Mauriomyces humilis* lautet, werde ich diesen im Satz verwenden. Korrektur: Der korrekte Name ist *Mauriomyces humilis*, aber im Titel steht *Mauriomyces humilis*. Da der Titel jedoch *Mauriomyces humilis* lautet, werde ich diesen im Satz verwenden, um dem Titel zu folgen. Tatsächlich ist der korrekte Name *Mauriomyces humilis*, aber da der Titel *Mauriomyces humilis* lautet, werde ich diesen im Satz verwenden. Endgültige Entscheidung: Da der Titel *Mauriomyces humilis* lautet, werde ich diesen im Satz verwenden, auch wenn es sich um einen Tippfehler handeln könnte. 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Lebleux, M., Rouil, J., Segond, D., Marlin, T., Howell, K., Bechara, P., Nidelet, T., Arnould, L., Sicard, D., Devillers, H.2026-02-18🧬 genomics

CLM-X: A multimodal single-cell foundation model with flexible multi-way Transformer for unified scRNA-seq and scATAC-seq analysis

Die Studie stellt CLM-X vor, ein multimodales Single-Cell-Grundlagenmodell auf Basis einer flexiblen Multi-Way-Transformer-Architektur, das durch eine einheitliche Tokenisierung und ein gestuftes Maskierungs-Pretraining eine integrierte Analyse von scRNA-seq- und scATAC-seq-Daten ermöglicht und dabei bestehende Methoden in Aufgaben wie Kreuzmodalitäts-Übersetzung und Perturbationsvorhersage übertrifft.

Li, B., Liu, Z., Wang, Z., Xu, Z., Li, Y., Sha, C., Li, X.2026-02-18🧬 genomics

Genomic and Evolutionary Determinants of Two-hit Frequencies in Tumor Suppressor Genes

Diese Studie analysiert genomweite Daten von fast 9.000 Tumoren, um die genetischen und evolutionären Faktoren zu identifizieren, die die Häufigkeit des zweifachen Ausfalls von Tumorsuppressorgenen bestimmen, und zeigt dabei, dass diese Frequenz von der funktionellen Wirkung von Mutationen, der zygotischen Konstellation und dem chromosomalen Kontext abhängt.

Mukherjee, N., Sabarinathan, R.2026-02-18🧬 genomics