📄 medicine

Self-reported adverse drug reactions to Dolutegravir-Based First-Line Antiretroviral Therapy and associated factors in Ethiopian patients: A Cross-sectional study

这项在埃塞俄比亚艾德综合专科医院进行的横断面研究发现,38.9% 接受多替拉韦类一线抗逆转录病毒治疗的患者报告了药物不良反应,其中居住在城市、疾病早期阶段开始治疗、初治状态以及合并使用其他药物被确定为显著的相关因素。

Goitom Belay, Alemseged Beyene Berha, Haftom Niguse Abraha, Eyasu Makonnen2026-07-13
📄 medicine

ETS2/c-Jun Inflammatory Storm Interceptor: Smart Dual-Responsive Temporal Regenerative Engine Reprograms Degenerative Nucleus Pulposus Microenvironment

本研究提出了一种智能双响应水凝胶微球,其能够按时间控制的顺序递送 MEK 抑制剂和柠檬酸,从而抑制 ETS2/c-Jun 炎症轴并重编程退行性髓核微环境,进而实现椎间盘的功能性再生。

Yusen Qiao, Jinhao Ni, Haifu Sun, Kang Wei, Xiaowei Zhang, Yuexing Wang, Yu Chen, Haowen Lu, Minbo Jian, Zijie Zhou, Lei (…)2026-07-13
📄 medicine

Understanding Contraceptive-Induced Menstrual Changes: Insights from contraceptive discontinuation due to side effects in 7 low- and middle-income countries

这项针对七个中低收入国家的跨国分析表明,避孕引起的月经变化是导致方法中断的主要原因,尤其是在青少年和注射剂使用者中,这凸显了从一刀切的计划生育方法转向个性化避孕干预措施的紧迫需求。

Catherine Akoth, Caleb Nyakundi, Sharonmercy Okemwa, Dorcas Nzilani Kanini, Lilian Ngina, Nancy Muthoni Nyaga, Irene mul (…)2026-07-13
📄 medicine

Parthenolide enhances imatinib activity in gastrointestinal stromal tumor models through stress-associated apoptosis

本研究表明, parthenolide 通过涉及活性氧(ROS)升高、线粒体功能障碍和内质网应激通路激活的机制,诱导应激相关凋亡,从而增强了 parthenolide 在胃肠道间质瘤模型中对伊马替尼抗肿瘤功效的作用。

Longyi Piao, Zheng-Gen Piao, Chun-Hua Zheng, Dongyuan Xu, Xi-Hui Li, Pengcheng Wei, Cho Park, Chuang-Ming Zheng, Toufeng (…)2026-07-13
📄 medicine

Immediate changes in cervical cancer early-detection knowledge and screening readiness after an experiential learning-based health promotion session in Indonesian Islamic study communities: a one-group pretest-posttest pilot study

这项针对印度尼西亚伊斯兰学习社区的一组单组前后测试点研究表明,基于体验式学习的健康促进课程显著提高了成年女性在子宫颈癌早期检测方面的即时知识、态度和准备度,尽管在进一步开展受控纵向研究以验证实际筛查率之前,其研究结果仍具有初步性。

Ayu Ulfah Nur Lubis, Asrial Asrial, Solha Efrida2026-07-13