📄 medicine

Admission Creatinine, Not Anticoagulant Class, Predicts In-Hospital Mortality in Anticoagulated Patients With Upper Gastrointestinal Bleeding

在一项关于服用抗凝药物的住院上消化道出血患者的回顾性多中心研究中,特定的抗凝药物类别并未能预测住院死亡率或其他临床结局,而入院血清肌酐被确定为死亡的独立预测因子。

Ali Sohail, Uday Sankar Akash Vankayala, Bivin George, Muhammad Abdurrahman Butt, Jessica Meng, Liliane Deeb2026-07-07
📄 medicine

Multidisciplinary Intervention for a Craniovertebral Junction Chondromyxoid Fibroma with Mutant-Pattern P53 Expression and Myogenic Differentiation:A Case Report

本病例报告详细阐述了通过精准的多模态手术方案,成功切除了一个极其罕见的、具有肌源性分化及 P53 突变型表达的颅颈交界处软骨黏液纤维瘤,并强调了该肿瘤发生恶性转化的潜力以及进行严格监测和针对性治疗策略的紧迫性。

Shaopeng Peng, Ke Shuai, Yan Yang, Bingwen Yu2026-07-07
📄 medicine

Prognostic Value of Preoperative Paraspinal, Gluteal and Abdominal Muscle Sarcopenia in Patients Undergoing One-hole Split Endoscopy for Lumbar Disc Herniation: A Retrospective Cohort Study

这项针对265例接受单孔分体内镜治疗腰椎间盘突出症患者的回顾性队列研究表明,术前肌少症以及椎旁肌和臀肌的脂肪浸润是慢性术后腰痛及较差长期功能预后的独立预测因子,这表明仅靠保肌手术技术无法完全补偿预先存在的生物力学损伤。

Xianyi Zhang, Mustafa Abbas Farhood Sultani, Jie Shang, Liang Guo, Guizhu Ji, Ziwei Xia, Chao Ma, Meng Han2026-07-07
📄 medicine

Associations Between Pre-Pregnancy Chronic Health Conditions and Spontaneous Abortion: A Large Retrospective Cohort Study

这项针对超过38.4万例妊娠病例的大型回顾性队列研究发现,几种孕前慢性健康状况与自发性流产风险增加显著相关,并据此开发了一种具有中度区分度但需在临床应用前进一步验证的探索性风险评分。

Hila SHALEV-RAM, Shai RAM, Nofar GABAY, Gal COHEN, Netanella MILLER, Tal BIRON-SHENTAL, Michal KOVO, Yael YAGUR2026-07-07
📄 medicine

Postoperative T10 Tilt at Two Weeks as an Early Prognostic Marker for Proximal Junctional Kyphosis and Failure After Adult Spinal Deformity Surgery

本研究表明,对于上端固定椎位于 T9 或 T10 的成人脊柱畸形患者,术后两周的 T10 倾斜度是近端连接性后凸及失败的独立预后指标,在早期风险评估方面具有与 L1 骨盆角相当或略优的适度预测价值。

Jae Heouk Choi, Dong Seok Kim, Jin S. Yeom, Sang-Min Park, Ohsang Kwon, Ho-Joong Kim2026-07-07
📄 medicine

Single-cell and spatial profiling of cysteine cathepsins identifies tumor states relevant to antibody-drug conjugates in breast cancer

本研究利用单细胞和空间图谱技术绘制了乳腺癌生态系统中半胱氨酸组织蛋白酶的异质性分布与活性图谱,揭示了将蛋白酶丰度、活性与靶抗原表达相结合,对于优化蛋白酶切割型抗体偶联药物的设计及患者分层至关重要。

Natalia Ćwilichowska-Puślecka, Natalia Małek-Chudzik, Oliwia Gorzeń, Tobiasz Puślecki, Jakub Mlost, Julia Nguyen, Bartos (…)2026-07-07
📄 medicine

Genomic Copy Number Variation Profiling of Pleural Effusion cfDNA via LP-WGS for Precision Diagnosis and Prognostic Stratification in Lung Adenocarcinoma-associated Malignant Pleural Effusion running title: cfDNA CNV for LUAD-MPE Diagnosis and Prognosis

本研究表明,基于低通量全基因组测序的胸水游离DNA拷贝数变异图谱分析是一种高度敏感、无创且具有成本效益的工具,能够准确诊断肺腺癌相关性恶性胸腔积液并进行患者预后分层,其表现优于传统的细胞学检查和癌胚抗原(CEA)检测。

Yujia Liu, Chao Shi, Haosong Zhou, Fangping Wang, Yupeng Liang, Xin Gan, Longhua Sun, Quqin Lu, Shiwen Luo2026-07-07