Comparative pharmacodynamic effects of processed Ligustri Lucidi Fructus against postmenopausal osteoporosis and potential mechanisms associated with the wine-steamed preparation: Integrating multidimensional pharmacodynamics, serum chemistry, and spatial metabolomics
本研究通过整合多维药效学、血清药效化学以及空间代谢组学,鉴定出其关键生物活性成分及其涉及调节肾脏色氨酸代谢和次级胆汁酸生物合成的机制,证明了酒蒸女贞果(JLLF)相比于其他炮制形式在治疗绝经后骨质疏松症方面具有更优越的治疗功效。