📄 medicine

Impact of body mass index on the clinical outcomes of immune checkpoint inhibitor combination therapy for advanced renal cell carcinoma: insights from gene expression and tumor-infiltrating immune cell profile

本研究表明,虽然在接受双免疫检查点抑制剂治疗的晚期透明细胞肾细胞癌患者中,体重指数(BMI)对预后没有显著影响,但接受 ICI-VEGFR 酪氨酸激酶抑制剂联合治疗的消瘦患者其生存率显著降低,这种差异可能是由消瘦个体中血管生成相关通路的下调所驱动的。

Hiroki Ishihara, Hironori Fukuda, Akihiro Kumono, Yuki Nemoto, Takayuki Nakayama, Koichi Nishimura, Shinsuke Mizoguchi (…)2026-07-07
📄 medicine

Assessment of Antibiotic Use in Pediatric Departments in Boma, Democratic Republic of the Congo, according to the WHO AWaRe Classification

一项针对刚果民主共和国博马地区420例儿科病例的回顾性研究显示,抗生素处方以世卫组织“监测”类药物为主,且受临床经验而非诊断检测驱动,尽管康复率很高,但仍显著偏离了国际AWaRe指南。

Tarcisse Kilara, Thérèse Mpiempie, Jean Paul Pholo, Teins Kasongo, Mireille Ngale, Jean Paul Divengi, Mamie Kondani, Fél (…)2026-07-07
📄 medicine

Nutritional Status, Personal Hygiene Practices, and Health-Seeking Behaviour Among Children in Child Care Institutions: A Mixed-Methods Cross-Sectional Study from Bhubaneswar, Odisha, India

这项针对印度布巴内斯瓦尔儿童的混合方法研究揭示了儿童护理机构中发育迟缓和消瘦的高患病率,确定了年龄较大和男性性别是针对消瘦的保护因素,并强调了持续政府资金投入以改善营养、卫生和求医行为的紧迫性。

Subhashreemalini Sahoo, Pradeep Kumar Panda, Paramjot Panda, Bharati Swaraj Sahu2026-07-07
📄 medicine

The Bridlington Eye Assessment Project Age-related Macular Degeneration Study (BEAP-AMD2): Characterising Phenotype-Genotype Associations in a UK Population Cohort

这项针对 55 岁及以上英国人群的前瞻性横断面研究,表征了年龄相关性黄斑变性(AMD)的患病率及其与第 1 号和第 10 号染色体上特定遗传变异的关联,揭示了尽管视网膜和脉络膜厚度随 AMD 严重程度而进行性下降,但这些结构性变化与遗传风险仅呈现出相关性的趋势,而这种趋势在其他高加索人群队列中也得到了验证。

Winfried Amoaku, Christian Pappas, Richard Gale, Vittorio Silvestri, Laura Cushley, Jill Hageman, Reuben Amoaku, Rukhsar (…)2026-07-07
📄 medicine

Associations of Voluntary and Required Group Physical Activity with Depressive Symptoms Among Chinese Adolescents: A Cross-sectional and Longitudinal Approach

这项研究表明,虽然自愿性的体育活动与中国青少年抑郁症状的减少具有强关联性,但强制性的团体体育活动在横断面研究中并未显示出益处,且在纵向研究中与抑郁症状的增加相关,尤其是在女孩群体中。

Yuru Du, Jianqiang Wang, Zheng Liu, Siyuan Chen, Youdong Li2026-07-07
📄 medicine

Cardiorenal Stress Phenotype, Renal Recovery, and Survival Outcomes in Newly Diagnosed Multiple Myeloma with Renal Impairment: A Real-World Cohort Study

这项真实世界队列研究表明,新诊断的伴有肾功能不全的多发性骨髓瘤患者表现出一种以 NT-proBNP 和 LDH 升高为特征的独特心肾应激表型,这种表型独立预测了异质性的肾功能恢复和较差的总生存期,提示仅凭血液学反应不足以进行预后评估,且心肾应激分层应被纳入临床管理。

Xiaoyan Liu, Jie Xiao, Xiuju Wang, Danian Nie, Chouxia Zhao, Dana Feng2026-07-07