📄 medicine

Structuring Self-Regulated Learning in Surgical Training: A Pilot Study of Paired Forethought and Reflection Instruments in Laparoscopic Cholecystectomy

这项试点研究表明,一种针对腹腔镜胆囊切除术设计的、基于理论指导的术前预想与术后反思配对工具具有可行性,且能被住院医师接受,并可以整合进常规手术工作流中而不干扰患者护理,尽管适度的完成率凸显了需要进一步开展对照研究以评估其对学习和表现的影响。

José Ignacio Rui-Wamba Barra, Bernardita Becker, Cristóbal Vildósola, Matias Aguilera, María Inés Gaete, Lorena Isbej, M (…)2026-07-01
📄 medicine

First-Cohort Micro-Credentialing in Thoracentesis and Paracentesis: Feasibility, Uptake, Retention, and Early Implementation Barriers in Procedural Training

这项前瞻性项目评估展示了胸腔穿刺术和腹腔穿刺术培训中四级微证书路径的可行性,报告了第一批学员中适度的参与度及成功的留存率,同时指出需要进一步评估同行评审者的可扩展性及长期影响。

Matías Aguilera, Felipe Riquelme, Mateo Ferrer, Felipe Araya, Vlada Vasilyeva, María Inés Gaete, Gabriel Escalona, Franc (…)2026-07-01
📄 medicine

Locally Led, Globally Impactful: A Simulation-Based Laparoscopic Skills Curriculum for Surgeons and Trainees in Ethiopia

由埃塞俄比亚国内教师授课的一种短期、由当地主导且基于模拟的课程,显著提高了外科医生及受训人员的腹腔镜知识与技术技能,这表明可持续的、由当地拥有的培训模式可以有效地扩大低资源环境下的微创手术能力。

Nathnael Abera Woldehana, Hilkiah Suga, Jochebed Suga, Zachary Enumah, Filagot Bizuneh Mikru, Ebenezer Fanta, Philimon G (…)2026-07-01
📄 medicine

Disagreement as a signal: an auditable dual-LLM and human-arbitrated workflow for methodological quality assessment in preclinical complex-intervention evidence

本研究引入了一种用于临床前复杂干预研究方法质量评估的可审计、人工仲裁的双大语言模型(LLM)工作流,证明了利用大语言模型之间的分歧作为针对性人工审查的信号,能有效识别系统性的方法论缺陷,同时确保透明度与准确性。

Jianpeng Hou, Changhui Wen, Kunpeng Lin, Lingao Xing, Xinyue Yu, Weiyu Liu, Xinyu Li, Yang Li2026-07-01
📄 medicine

Clinical and genomic predictors of sipuleucel-T outcomes in men with metastatic androgen pathway modulator resistant prostate cancer

这项针对429例接受sipuleucel-T治疗的转移性雄激素通路调节剂耐药性前列腺癌男性的回顾性研究表明,MYC基因扩增是预后差的最强独立基因组预测因子,同时还包括广泛骨转移、高龄和碱性磷酸酶升高等临床因素。

Andrew Armstrong, Tara Seibert, Jane McKenzie, Lauren Howard, Bilal Ashraf, Jasmine Lu, Kallie White, Daniel George, Jef (…)2026-07-01
📄 medicine

Attenuation of Reactive Astrogliosis Accompanies Neurological Recovery Induced by Novel Poly-Target 2,3-Benzodiazepines After Experimental Traumatic Brain Injury

新型多靶点 2,3-苯并二氮杂䓬衍生物 MPTD-01 和 BS34-20 在大鼠创伤性脑损伤模型中显著改善了神经功能恢复和生存率,同时减轻了反应性星形胶质细胞增生,支持了其作为多靶点神经保护剂的潜力。

Sergiy Ziablitsev, Nadia Aleksandrenko, Danylo Yevstifeiev, Mykola Babenko, Volodymyr Likhodiievskyi2026-07-01