📄 medicine

Safety and efficacy of pertuzumab and trastuzumab in patients with HER2-Positive metastatic colorectal cancer: comparison of intravenous and subcutaneous formulations. ​

这项回顾性研究表明,在HER2阳性转移性结直肠癌患者中,皮下注射剂型的帕妥珠单抗和曲妥珠单抗与静脉注射剂型相比,具有相当的疗效和更低的输注相关反应发生率,同时显著缩短了治疗过程时间。

Momoka Furuoka, Saori Mishima, Akihito Kawazoe, Yu Miyashita, Yuki Matsubara, Tadayoshi Hashimoto, Izuma Nakayama, Daisu (…)2026-09-04
📄 medicine

Toward Optimising Multiple Sclerosis MRI Protocols: A Comparative Study of Lesion Detection and Quantitative Image Quality Across MRI Sequences

这项针对23例多发性硬化症患者的比较研究表明,3D FLAIR在病灶检测方面较之常规2D FLAIR有显著提升,而T2加权成像则提供了更优越的对比噪声比,从而支持将这两种序列整合入一种优化的混合MRI方案中,以实现更准确的疾病评估。

Sara Bassam Al-Qaralleh, Marwan Alshipli, Sahar Mahmoud Abd elsalam, Ahmed Sayed Abd El Basset2026-09-04
📄 medicine

Severe MASLD and Metabolic Burden Are Associated with Reduced HBsAg Clearance During Pegylated Interferon Therapy in HBeAg-Negative Chronic Hepatitis B

在HBeAg阴性且基线HBsAg水平较低的慢性乙型肝炎患者中,严重的代谢功能障碍相关脂肪性肝病(MASLD)和高累积代谢负担与HBsAg清除率降低独立相关,而轻度至中度MASLD则不会显著损害治疗反应。

Pengxuan Wu, Jianxia Dong, Dacheng Sheng, Lilin Wang, Xinyue Meng, Jing Zhao, Shan Ren, Sujun Zheng2026-09-04
📄 medicine

Severe Injuries in Competitive Cycling During an Olympic Cycle: Injury Patterns, Time Loss, and Return-to-Performance Outcomes

这项针对192名自行车运动员、跨越一个奥运周期的回顾性研究显示,严重损伤影响了37.5%的运动员,其主要表现为比赛期间的创伤性上肢骨折以及训练期间的过度使用性膝盖损伤,且不同损伤类型和学科在停赛时间和重返竞技水平的结果方面存在显著差异。

Christophe LAMBERT, Maxime Lambert, Marlene Galandi, Bernd WOLFARTH, Casper GRIM, Sven SHAFIZADEH, Ramona RITZMANN2026-09-04
📄 medicine

Effects of Home-Based Gait Training with Exoskeleton Robot on Lower Limb Motor Function and Hip Stability in Children with Type 2 Spinal Muscular Atrophy: A Single-Arm Self-Controlled Trial

这项单臂自身对照试验表明,为期12周的居家外骨骼步态训练计划对于2型脊髓性肌萎缩症儿童是安全且可行的,该计划显著改善了日常生活活动能力和下肢肌肉力量,并在粗大运动功能和髋部稳定性方面呈现出积极但无统计学意义的趋势。

Huawei Zhang, Xiaohua Guo, Wanpeng Chang, Minggang Yi, Yujie Yang, Yanbo Cao, Jicong Liu, Ge Wang, Feifei Wang, Tian Wan (…)2026-09-04
📄 medicine

Leveraging electronic medical and financial records to estimate financial costs of delivering health services in health facilities: a multi-site retrospective study in Burundi

这项在布隆迪开展的多中心回顾性研究利用电子医疗和财务记录估算出医疗成本随医疗机构层级的提升而增加,揭示了不同的成本驱动因素(卫生中心的药品与医院的人员),并主张通过差异化的报销标准和针对性的管理策略来支持全民健康覆盖。

Alain NDAYIKUNDA, Frank VERBEKE, Joseph NYANDWI, Manassé NIMPAGARITSE, Ronald BUYL2026-09-04
📄 medicine

Postoperative weight-bearing beyond recommended limits following total elbow arthroplasty: Does it matter for loosening, complications, and revisions?

这项针对51名患者的回顾性研究发现,术后自我报告的举重重量超过5公斤的标准限制,与人工全肘关节置换术后假体松动、并发症或翻修手术发生率的增加并无关联,这表明个体化咨询可能比僵化的重量限制更为合适。

Tamara Babasiz, Nadine Ott, Felix Krane, Lars Peter Müller, Tim Leschinger2026-09-04