📄 medicine

ENO1 Links Glycolytic Metabolism, HBV Replication, and Immune Evasion in HBV-Related Hepatocellular Carcinoma

本研究确定了烯醇化酶1 (ENO1) 是乙型肝炎病毒(HBV)相关肝细胞癌中一个关键的免疫代谢枢纽,它将糖酵解重编程和 HBV 复制与免疫逃逸联系起来,从而驱动肿瘤进展,并有望成为一种极具前景的预后生物标志物和治疗靶点。

Meiying Gu, Yihong Zeng, Qingcao Fei, Huijuan Liu, Lina Ma, Yanchao Hu, Xiangchun Ding2026-09-03
📄 medicine

Standard C-Reactive Protein and Time to Death in Geriatric Outpatients: A Prognostic Signal Absent in the Oldest-Old

本研究发现,虽然高水平的标准C反应蛋白能独立预测老年门诊患者更短的死亡时间,但这一预后信号仅对80岁以下人群具有显著性,而在高龄老人中并不存在,这表明在解读CRP时应具备年龄意识,而非将其作为单一指标使用。

Okan Turhan, Zeynep Özge Özdemir, Serdar Ceylan, Ceyda Kayabaşı, Murat Pehlivan, İskender Arda Nacar, Özge Özgün, Deniz (…)2026-09-03
📄 medicine

Platelet-rich plasma enhances human umbilical cord mesenchymal stem cell-mediated improvement of erectile function and modulates extracellular matrix remodeling in diabetic rats

本研究表明,与单药疗法或序贯给药相比,同时输注富血小板血浆(PRP)和人脐带间充质干细胞(hUC-MSCs)能显著增强对大鼠糖尿病性勃起功能障碍的治疗效果,这主要是通过提高干细胞持久性、减轻 TGF-β1/Smad 介导的纤维化,以及通过整合素 α7 相关信号通路使细胞外基质重构恢复正常来实现的。

Jiahao Sun, Zhixiang Meng, Pengfei huan, Wei Wang, Siyuan Pan, Kehan Liu, Yu Zhang, Zhilong Dong, Zuobin Zhu, Conghui Ha (…)2026-09-03
📄 medicine

Clinical Outcomes of Pregnancy in Women with Advanced Chronic Kidney Disease and on Dialysis: A Shared Decision-Making and Multidisciplinary Precision Management Approach

这项回顾性研究表明,通过线上线下结合的混合模式实施基于共同决策的多学科精准管理模型,能够显著提高患有晚期慢性肾脏病或正在接受透析的孕妇的母体及胎儿生存率和临床结局。

Xun Mao, Lili Cheng, Mingfang Zhou, Yushuang Qin, Shan Hu, Juan Huang, Xin Xi, Qian Du, Liyan Wang, En Tian, Lirong Lin (…)2026-09-03
📄 medicine

Nonlinear Symptom Escalation and Residual Burden After Recovery in Adolescent Depression: Cross-Validated Trajectory Analysis in 2,809 Chinese Adolescents

这项针对2,809名中国青少年的三年纵向研究识别出四种不同的抑郁症状轨迹,揭示了其中一个亚组经历了非线性的、加速的症状升级,而另一个亚组在改善后仍保留了显著的残留负担,且研究结果通过高跨方法一致性得到了验证,并与特定的统计学特征和临床预测因子相关联。

Juan Zhang, Wen Wang, Fang Wang, Yujie Liu, Di He, Lianzhong Liu2026-09-03