🧬 biology

Technical replicates and multiple sequencing approaches reveal weak and inconsistent microbiome signals in tumour and blood samples

这项研究表明,低生物量肺癌肿瘤、相邻组织及血液样本中的微生物组信号微弱、不一致且与污染无法区分,凸显了对技术重复和绝对定量等严格验证方法以确保数据可靠性的迫切需求。

Vanessa DeClercq, André M Comeau, Alessi Kwawukume, Rowan Murphy, Nidhi R Parmar, Dylan P Quinn, Robyn Wright, Alison Wa (…)2026-06-28
🧬 biology

The Influence of 5-HT2 Receptors on Multimodal Sensorimotor Gating and Hallucination-Like Behavior in Hemiparkinsonian Rats

本研究表明,偏侧帕金森病大鼠表现出多模态感觉运动门控受损以及对 5-HT2 受体介导的幻觉样行为敏感性增高,这提示 5-HT2 受体的上调显著导致了帕金森病中与精神病相关的症状。

Shruti Venkatesh, Haley Prisinzano, Natalie Lipari, Jacleen Nardiello, Carla Budrow, Grace McManus, Emily Wheelis, Fredr (…)2026-06-28
🧬 biology

Low flow enhances pigmentation and lipid reserves but reduces survival in newly settled Acropora digitifera corals

虽然低水流增强了新定居的枝状鹿角珊瑚(*Acropora digitifera*)的色素沉着和脂质储备,但与中等和高水流机制相比,它显著增加了早期死亡风险,这表明有利于生理发育的最佳条件并不一定能使生存率最大化。

Saskia Jurriaans, Mark Deleja, Victoria Jenkins, Annika Withers, Carrie A. Sims, Carly J. Randall2026-06-28
🧬 biology

[3H]5-MOP: a novel and selective colony stimulating factor-1 receptor (CSF1R) radiotracer

本研究验证了 [3H]5-MOP 是一种新型、高选择性且高亲和力的 CSF1R 受体放射配体,其性能优于 [3H]CPPC 等现有工具,因其不存在与其他脑激酶的交叉反应性,从而能够实现对神经炎症和药物占用的准确神经影像学成像。

Camilla Iavazzo, Burcu A. Pazarlar, Benny Bang-Andersen, Thomas Jensen, Morten Hentzer, Jesper F. Bastlund, Jeppe L. Has (…)2026-06-28
🧬 biology

Effect of Photobiomodulation on Platelet-Rich Fibrin Cellular Distribution and Fibrin Architectures: An In Vitro Split-Sample Controlled Experimental Study

这项体外拆分样本研究表明,光生物调节作用以波长依赖的方式显著增强了富血小板纤维蛋白的细胞分布、纤维蛋白结构和生长因子释放,其中 940 nm 最优地优化了结构完整性,而 660 nm 和 810 nm 则优先促进了特定的生长因子反应。

Muharrm othman, abdulghani aldhahiby, wael alshargabi2026-06-27
🧬 biology

Genome-wide identification and integrative analysis of the WRKY gene family reveal candidate regulators involved in biotic stress responses in Hass avocado

本研究系统地表征了哈斯鳄梨中由70个成员组成的WRKY基因家族,揭示了其通过片段重复进行的进化扩张,并识别出在调节针对昆虫食草作用和病原体感染的差异化防御反应中起关键作用的特定候选基因。

Xiafei Wang, Zekun Shi, Bo Yuan, Liang Tao, Yangmei Zhang, Zhonghua Wu, Hongchang A, Guoyuan Zhu, Liyue Xu, Yongke Zhang (…)2026-06-27
🧬 biology

Growth heterogeneity of Streptococcus suis in host-mimicking conditions is independent of clinical origin

本研究表明,在模拟宿主条件下,不同菌株的兼利史特玲菌(*Streptococcus suis*)表现出具有菌株特异性的生长异质性,且这种现象与临床来源无关,凸显了代谢适应和营养可用性在塑造细菌适应性方面的关键作用。

Ayelén Perez-Falcón, Karl Kochanowski, Igor Florez-Sarasa, Elisenda Feixes-Prats, Florencia Correa-Fiz, Virginia Aragon2026-06-26