🧬 biology

Glucose Metabolism-Related Crosstalk Genes Between Osteoporosis and Frozen Shoulder Identified by Integrated Bioinformatics and Machine Learning Reveal Shared Diagnostic Biomarkers and Immune Microenvironment Characteristics

本研究整合了生物信息学与机器学习技术,识别出四个葡萄糖代谢相关交叉基因(MARCKS、MAP3K1、LTF 和 ZMIZ1)作为骨质疏松症与冻结肩的共同诊断生物标志物,揭示了它们与不同免疫微环境的关联性及潜在的治疗靶点。

Wei Hao, Long Fang, Baolong Wang, Ziwei Hou, Lizhong Jing, Jiushan Yang2026-09-09
🧬 biology

Dynamic interaction balance control of relative abundances buffers community instability

通过对长期水生微生物数据应用经验动态建模,本研究揭示了群落通过一种被称为相互作用平衡控制的涌现机制来维持动态稳定性,即在这一机制下,优势种经历净负相互作用,而非优势种经历净正相互作用,从而缓冲丰度波动。

Carmen García-Comas, Chun-Wei Chang, Judith Traver-Azuara, Caterina Giner, Ramiro Logares, Chih-hao Hsieh, Pedro Cermeño2026-09-09
🧬 biology

Bioactive Compounds in Persea americana var. Quintal Byproducts: Exploring Their Antioxidant Potential and Inhibitory Effects on LDL Oxidation, Lipid Peroxidation, and Nitric Oxide Production

本研究表明,鳄梨(*Persea americana* var. Quintal)副产品(果皮和种子)的乙醇提取物及有机组分富含原花青素和槲皮素等生物活性化合物,表现出显著的抗氧化、抗脂质过氧化及抑制一氧化氮活性作用,且无细胞毒性,从而突显了其作为氧化应激相关疾病天然治疗剂的潜力。

Maria Sol Peña Carrillo, Romário Divino Vilarinho Galvão, Ana Luiza Silva Borges, Vinícius Prado Bittar, Iasmin Aparecid (…)2026-09-09
🧬 biology

Investigation of Stress Granule-Associated Biomarkers (IGF1 and CDK2) and Their Regulatory Mechanisms in Alzheimer’s Disease: A Combined Transcriptomic, Bioinformatic and Experimental Study

本研究整合了转录组分析、机器学习和实验验证,旨在将 IGF1 和 CDK2 鉴定为阿尔茨海默病的潜在生物标志物,通过神经网络模型展示了强大的诊断性能,并通过 miRNA 相互作用和分子对接阐明了它们的调节机制,尽管在临床样本中存在部分验证差异。

Milisha Wusiyin, Xinxue Wei, Xiaobei Liu, Aersi Aheizan, Abuduxukuer Maituzi, Rong Huang2026-09-09
🧬 biology

Genome-wide Identification and Characterization of the 3- Dehydroquinate Dehydratase/Shikimate Dehydrogenase Gene Family in Rubus chingii Hu

本研究系统地鉴定并表征了蔓越莓(*Rubus chingii*)中的四成员 RcDHD/SDH 基因家族,揭示了其结构特征、组织特异性表达模式,以及其早期果实发育过程中的表达与没食子酸和鞣花酸积累之间的强相关性。

Xueli An, Yuezhen Li, Yating Gong, Nana Feng, Bowei He, Dongfeng Yang, Hongfa Li, Jianhong Chen, Zhuoni Hou, Zongsuo Lia (…)2026-09-09
🧬 biology

Digestion and Gut-Modulating Functions of Six Dietary Oils: A Multi-Omics- Based Investigation into Oxidative Stability, Gas Production Profiles, and Microbiota Shifts

这项多组学研究利用体外消化模型证明,六种膳食油脂的氧化稳定性、结肠产气特征以及肠道微生物群的变化,是由其脂肪酸组成独特决定的,揭示了像鱼油和花生酸(ARA)这类多不饱和油脂与具有较温和发酵效应的橄榄油和山茶油相比,会促进更高的产气量和特定的细菌增殖。

Yating Wang, Shuya Chen, Jintian Chen, Xixian Lv, Yin Yin, Wenxuan Yan, Zepeng Chang, Minjie Gao, Shiwei Song, Zhitao Li (…)2026-09-09