🧬 biology

Sleep dysfunction mediates the relationship between hemodynamic response height of the secondary somatosensory cortex and fear-somatic symptom severity bidirectionally in young adults

这项针对735名年轻人的研究表明,睡眠功能障碍在次级躯体感觉皮层血流动力学反应高度降低与恐惧躯体症状严重程度增加之间的关系中起到了双向中介作用。

Dandan Zhong, Lin Yang, Ning Zhang, Zhao Zhang, Yan Yan, Sihan Niu, Jianyu Dong, Yiyao Yelin, Ying Li, Guangfei Li, Chia (…)2026-09-02
🧬 biology

Aberrant anterior insular functional connectivity patterns and intestinal microbiota differences in mild traumatic brain injury patients accompanied by cognitive impairment

这项研究揭示了伴有认知功能障碍的轻度创伤性脑损伤患者表现出独特的肠道菌群改变和前岛叶功能连接中断,提示可能存在涉及特定细菌属的肠-脑轴机制,这可能导致情绪障碍和认知缺陷。

Youling Li, Linkai Chen, Jie Chen, Pinghui Zhao, Tianhui Li, Bo Yin, Guanghui Bai2026-09-02
🧬 biology

Using wearable EEG to examine age trends in sleep macro- and micro-architecture across adolescence

本研究表明,Dreem3 可穿戴式脑电图头带成功复制了青少年时期已建立的睡眠宏观与微观结构随年龄变化的趋势,从而验证了其作为传统实验室多项睡眠图在表征睡眠生理发育方面的一种便捷替代方案的可行性。

Sanna Lokhandwala, Rebecca Cooper, Rebecca Hayes, Soumya Sathe, Isabelle Elder, Mary Corcoran, Beatriz Horta, Maya Fray- (…)2026-09-02
🧬 biology

Exploration of key genes associated with pyruvate metabolism in nonalcoholic fatty liver disease based on single-cell and bulk RNA-seq data

本研究结合大块 RNA 测序与单细胞 RNA 测序及实验验证,鉴定出 ACOT12 和 SLC16A1 是非酒精性脂肪肝中关键的丙酮酸代谢相关基因,阐明了它们在免疫浸润和疾病进展中的作用,并提出了潜在的治疗小分子。

Ting Zhang, Haoran Zhang, Shuangshuang Wang, Xuemei Yang, Xiao Qiu, Qiao Zhang2026-09-02
🧬 biology

RGS10 controls the metabolic and neuroinflammatory benefits of NLRP3 suppression in diet-induced obesity in male mice.

本研究确定 RGS10 是雄性小鼠中 NLRP3 炎性小体的一个关键且具有性别依赖性的上游调节因子,证明了其缺失会消除在饮食诱导的肥胖中通过抑制 NLRP3 所获得的代谢和神经炎症益处,并提示与年龄相关的 RGS10 下降可能会限制针对 NLRP3 靶向疗法的疗效。

Jae-Kyung Lee, Declan Gresham, Jaegwon Chung, Jung Ha Byun, Yu Zhang, Nicole Zhang, Adetutu Adebowale, Yoon-Seong Kim, J (…)2026-09-02