Optimizing Complex Health Intervention Packages through the Learn-As-you-GO (LAGO) Design
本文介绍了“边学边做”(LAGO)研究设计,该设计通过在试验过程中分阶段动态优化复杂的多组分健康干预方案,旨在以最小成本实现预设的统计功效和效果目标,从而降低传统随机对照试验在复杂公共卫生干预中失败的风险,并通过 BetterBirth 研究及多项 HIV 与非传染性疾病试验案例论证了其应用价值。
Donna Spiegelman (Center on Methods for Implementation,Prevention Science,,Department of Biostatistics, Yale University), Dong Roman Xu (Southern Medical University Institute for Global Health), Ante Bing (Department of Mathematics,Statistics, Boston University), Guangyu Tong (Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University), Mona Abdo (Center on Methods for Implementation,Prevention Science,,Department of Biostatistics, Yale University), Jingyu Cui (Center on Methods for Implementation,Prevention Science,,Department of Biostatistics, Yale University), Charles Goss (Center for Biostatistics,Data Science, Washington University School of Medicine), John Baptist Kiggundu (Infectious Diseases Research Collaboration), Chris T. Longenecker (Division of Cardiology,Department of Global Health, University of Washington), LaRon Nelson (Yale School of Nursing, Yale University), Drew Cameron (Department of Health Policy,Management, Yale University), Fred Semitala (Infectious Diseases Research Collaboration,,Department of Medicine, Makerere University,,Makerere University Joint AIDS Program), Xin Zhou (Center on Methods for Implementation,Prevention Science,,Department of Biostatistics, Yale University), Judith J. Lok (Department of Mathematics,Statistics, Boston University)Mon, 09 Ma📊 stat