9 papers
This retrospective matched-pair study indicates that while general anesthesia is hemodynamically well-tolerated in patients with myalgic encephalomyelitis/chronic fatigue syndrome, they experience significantly higher postoperative pain and a greater need for rescue analgesia compared to matched controls.
This bi-directional Mendelian randomization study reveals that while down-regulated IL-6 signaling may causally reduce perioperative stroke risk, the divergent effects of inflammatory markers between acute postoperative and chronic all-cause outcomes suggest distinct underlying mechanisms, and previously reported associations between CRP and delirium likely stem from horizontal pleiotropy rather than direct causation.
This study utilizing UK Biobank and FinnGen data reveals that while only postoperative atrial fibrillation yielded genome-wide significant risk loci, postoperative complications generally share a strong genetic architecture with their non-postoperative equivalents, suggesting that preoperative genetic risk scores could help stratify patients for potential surgical complications.
In a large UK Biobank cohort study, adding high-dimensional metabolomic and proteomic data to standard clinical variables failed to improve the prediction of postoperative complications, likely due to the temporal gap between sample collection and surgery, although transfer learning techniques enhanced model stability.
This large-scale retrospective study reveals that despite age-based dose reductions in real-world practice, older adults still experience disproportionately high propofol brain exposure because weight-based dosing heuristics fail to adequately account for age-related increases in hypnotic sensitivity, supporting a shift toward exposure-informed and neurophysiologically guided induction titration.
This prospective cohort study conducted in Ethiopia found that women undergoing repeat cesarean sections under spinal anesthesia experience significantly higher postoperative pain severity and require greater analgesic consumption within the first 24 hours compared to those having primary cesarean sections.
This manikin-based study demonstrates that glottic forces during endotracheal intubation are primarily determined by the use of a stylet and the specific laryngoscopy technique employed, rather than by operator experience or anthropometric characteristics, highlighting stylet use as the most significant modifiable factor contributing to potential airway trauma.
This study analyzes UK clinical and genetic data from 1988 to 2025 to demonstrate that the disparity between malignant hyperthermia incidence and RYR1 variant prevalence is best explained by a threshold inheritance model with variable penetrance across genotypes, rather than simple autosomal dominant inheritance.
This prospective observational study demonstrates that a remotely administered comprehensive neurocognitive test battery (UDS v3.0 T-cog) is a feasible, well-accepted, and sensitive tool for detecting postoperative cognitive decline in older adults undergoing orthopedic surgery, identifying deficits in 17% of patients that brief screening instruments might miss.