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Today's pick🧬 genomics

A genomic tool to tackle cryptic diversity demonstrates the potential for off-target use of GT-seq panels

Imagine trying to solve a massive puzzle where all the pieces look exactly the same. That is the challenge scientists face when studying certain fish, specifically a group called the Coregonus artedi complex in the Great Lakes. These fish are like identical twins; even their DNA "fingerprints" (specifically mitochondrial DNA) look so similar that traditional methods can't tell them apart.…

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{triangleup}9-Tetrahydrocannabinol exposure shifts eosinophil and macrophage transcriptional programs towards an anti-inflammatory phenotype in helminth infection

Sustained exposure to {Delta}9-tetrahydrocannabinol (THC) in mice infected with the helminth *Nippostrongylus brasiliensis* does not alter parasite burden but reshapes the immune response by restraining innate and T cell effector functions and shifting lung eosinophil and macrophage transcriptional programs toward an anti-inflammatory, stress-adaptive phenotype that mitigates tissue remodeling.

Jennett, J., Olmos, M., Lam, K. M., Midou, S., DiPatrizio, N. V., Nair, M. G.2026-06-12🛡️ immunology

Interactions between single actin and vimentin filaments

Using quadruple optical tweezers and a Bayesian unmasking strategy, this study demonstrates that single actin and vimentin filaments form direct, force-bearing interactions independent of crosslinking proteins, with bond strengths that are robust to ionic strength variations but constrained by the mechanical limits of actin filaments.

Kumari, P., Lambert, S., Bhattacharyya, K., Pajanonot, K. A. T., Klumpp, S., Koester, S.2026-06-12⚛️ biophysics

Spatial Organization of Lipids Drives GPCR Conformational Equilibria

This study demonstrates that the spatial organization of anionic lipids within lipid nanodiscs, driven by clustering and interactions with the membrane scaffold protein, critically regulates the conformational equilibria of the A2A adenosine receptor, a mechanism that can be modulated through targeted protein engineering.

Wijesekara, A. V., Ji, J., Afsharian, N. P., Zhang, K., Thakur, N., Ray, A. P., Elmaleh, B., Pour, N. G., Lyman, E., Eddy, M.2026-06-12⚛️ biophysics

Kombucha-Derived Cellulose Non-wovens: Growth Optimization, Mechanics, and Recycling

This study optimizes the growth conditions and post-processing methods for kombucha-derived cellulose non-wovens to achieve superior mechanical properties via lyophilization, while demonstrating a circular lifecycle through enzymatic degradation and electrospinning-based re-manufacturing.

He, L. L., Lopez, J., Schiffman, J. D.2026-06-12📄 bioengineering

Representations of spatial saliency in auditory cortex are selectively organized through temporal coordination

Using laminar electrophysiology in mice, this study demonstrates that behaviorally relevant sound locations selectively enhance auditory cortical encoding not by altering firing rates, but by dynamically increasing temporal coordination, reliability, and gamma-band spike-field coupling.

Irani-Cereceda, M., Qu, Z., Sen, K., Sadaghiani, S., Gritton, H.2026-06-12🧠 neuroscience

RAI1 safeguards fidelity and tempo of human neurodevelopmental gene expression

This study demonstrates that the RAI1 gene acts as a critical brake on human neurodevelopment by suppressing mesodermal lineage programs and slowing the tempo of gene expression, thereby ensuring the fidelity and prolonged timeline necessary for advanced cognitive development.

Zhou, B., Mohanty, S., Riggle, P., Tsukahara, T., Lin, G., Dang, L. T., Sutton, M. A., Iwase, S.2026-06-12🧠 neuroscience

Isolation of postnatal human neural stem cells

This study identifies and characterizes two distinct subsets of postnatal human neural stem cells (NINO and NAC) with specific differentiation biases, revealing that while their frequency declines exponentially during the first two decades of life, they persist into old age, providing a new framework for studying human brain development and aging.

Liu, D. D., Eastman, A. E., Womack-Gambrel, N. L., Kim, C. N., He, J. Q., Raj, S., Reilly, E., Sinha, R., Uchida, N., Chau, K., Ohene-Gambill, B. F., Thapa, S., Nasajpour, E., Belk, J. A., Neff, N. F. (…)2026-06-12🧠 neuroscience

Is Stochastic Gradient Descent Effective? A PDE Perspective on Machine Learning processes

This paper analyzes the effectiveness of Stochastic Gradient Descent (SGD) in non-convex optimization by modeling it through degenerate Fokker-Planck PDEs, identifying distinct drift and diffusion regimes to quantify weight concentration, escape times from local minima, and asymptotic convergence using novel duality and entropy techniques.

Davide Barbieri, Matteo Bonforte, Peio Ibarrondo2026-06-12🔢 math

Geometry of Lightning Self-Attention: Identifiability and Dimension

This paper employs algebraic geometry to analyze the function spaces of unnormalized self-attention networks, establishing their identifiability and dimension while characterizing singular points and conjecturing these results for normalized architectures.

Nathan W. Henry, Giovanni Luca Marchetti, Kathlén Kohn2026-06-12🔢 math

Growing Binary Trees

This paper introduces a novel combinatorial framework for modeling binary tree growth through discrete evolution rules that link dynamic processes to classical unlabeled trees and Mandelbrot polynomials, ultimately enabling the development of an optimal iterative sampler for generating trees with prescribed profiles.

Olivier Bodini, Antoine Genitrini, Khaydar Nurligareev2026-06-12🔢 math

Explosion and non-explosion in pure birth Crump--Mode--Jagers branching processes

This paper establishes an explicit sufficient condition for the non-explosion of pure birth Crump--Mode--Jagers branching processes that is nearly necessary for non-oscillatory rates, while simultaneously providing a counterexample that resolves an open question by constructing a preferential attachment tree with an infinite path but no vertices of infinite degree.

Oleksii Galganov, Andrii Ilienko2026-06-12🔢 math

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