73 papers
This study reveals that mutant huntingtin in Huntington's disease forms fragile, dynamic polyQ assemblies that encircle and disrupt the Golgi apparatus, leading to a specific "Golgipathy" characterized by impaired Golgi structure, function, and vesicle trafficking.
This paper presents an optimized, rapid three-minute Hematoxylin and Oil Red O (H-ORO) staining protocol for frozen zebrafish sections that effectively visualizes nuclear and lipid-rich structures while preserving tissue integrity and minimizing artifacts associated with traditional ethanol-based methods.
This study reports evidence suggesting that the fungus *Rhizoctonia theobromae*, which causes Cassava witches' broom disease in French Guiana, may have jumped hosts to infect cacao trees, posing a significant threat to cacao production and biodiversity in the Amazon region.
This study utilizes autopsy-based longitudinal multi-organ profiling to reveal that therapeutic resistance and aggressiveness in secretory breast carcinoma are driven by lineage plasticity and hierarchical transcriptional rewiring arising from a shared clonal origin.
Using the K18-hACE2 mouse model, this study demonstrates that SARS-CoV-2 infection targets neurons without directly damaging blood vessels, triggering a secondary neuroinflammatory response characterized by leukocyte recruitment and minimal blood-brain barrier dysfunction.
This study demonstrates that collecting duct-derived soluble (pro)renin receptor (sPRR) promotes renal fibrosis in a mouse model of unilateral ureteral obstruction by activating the AT1R/Yap/Taz signaling axis to drive macrophage M2 polarization.
This study reveals that myeloperoxidase (MPO) drives pulmonary fibrosis by post-translationally inhibiting the collagen-degrading enzyme cathepsin K, thereby shifting the lung toward excessive extracellular matrix accumulation and correlating elevated MPO levels with poor patient outcomes.
Cardiomyocyte-specific deletion of the m6A methyltransferase METTL14 triggers myocarditis and dilated cardiomyopathy by disrupting mitochondrial integrity and autophagy, which leads to RIPK1 accumulation, hyperactivation of type I interferon signaling, and necroptosis.
This study demonstrates that computational analysis of routine Masson-Goldner Trichrome-stained histopathological images can accurately quantify collagen architecture in breast tumors with significant concordance to specialized Second Harmonic Generation microscopy, offering a scalable and clinically accessible alternative for assessing extracellular matrix organization.
This study analyzes the pathological findings and causes of death in 316 stranded cetaceans in the Canary Islands from 2013 to 2018, revealing that natural causes (73.6%) predominated over anthropogenic factors (12.9%) while documenting novel disease patterns and reaffirming established mortality trends to support conservation strategies.
This study reveals that UVB irradiation triggers a pathogenic skin-kidney axis in lupus-prone mice by inducing PKC-dependent nuclear envelope rupture for NET formation and CXCR4-mediated migration of primed neutrophils from the skin to the kidneys, thereby driving systemic inflammation and organ damage.
Quantitative proteomic analysis of whole cardiac tissue sections in ATTR amyloidosis reveals that, beyond amyloid deposition, the disease is characterized by significant upregulation of extracellular matrix remodeling proteins, complement factors, and coagulation factors, highlighting active tissue restructuring as a key pathological feature with potential therapeutic implications.
This study establishes that in a zebrafish model of Bethlem myopathy, collagen type VI deficiency disrupts CaV1.1 localization and function, leading to pathological sarcoplasmic reticulum calcium leaks that drive progressive muscle weakness and wasting.
This study demonstrates that even in acute *Plasmodium vivax* malaria, the spleen harbors approximately 89% of the total parasite biomass and acts as a critical regulator of systemic inflammation and disease intensity, whereas its absence leads to higher circulating parasitemia but paradoxically lower total parasite load and altered inflammatory responses.
This study reveals that an imbalance between the pro-apoptotic TAp73 and anti-apoptotic ΔNp73 isoforms, often driven by 1p36 chromosomal disruption, critically influences survival and chemoresistance in diffuse large B-cell lymphoma, positioning ΔNp73 as a key biomarker for aggressive disease and a potential therapeutic target.
This study demonstrates that while global ELMO1 deficiency does not affect ischemia-reperfusion injury, it exacerbates cisplatin-induced acute kidney injury by impairing efferocytosis in renal cells, thereby increasing tissue damage and apoptosis.
HistoSB-Net addresses the semantic misalignment of pre-trained vision-language models in data-limited histopathology by introducing a constrained semantic bridging module that adaptively modulates attention projections to achieve robust, unified patch- and whole-slide image diagnosis with minimal additional parameters.
This paper analyzes the rapidly expanding market of commercial AI devices for digital pathology image analysis, revealing that while numerous products exist—particularly for cancer detection in breast and prostate tissues—there is a significant lack of published clinical validation studies, diverse dataset quality, and evidence regarding clinical utility and cost-effectiveness, underscoring the urgent need for greater transparency and rigorous independent scrutiny.
This study identifies mdc-STM-001, a long-acting injectable ivermectin formulation, as the lead candidate for malaria control in Western Africa because it demonstrates a favorable pharmacokinetic profile and sustained efficacy in killing pyrethroid-resistant *Anopheles* mosquitoes for at least two months following a single cattle injection.
This paper presents a cost-effective, nucleic acid-independent computer vision platform that utilizes cross-species machine learning to detect live blood cells carrying malignancy-associated mutations (KMT2A-MLLT3 or JAK2-V617F) through high-throughput single-cell morphology analysis, offering a promising tool for pre-malignant screening.