32 papers
Pathology is the study of how diseases change the body, uncovering the hidden causes of illness and how they progress. From examining tissue samples to understanding molecular shifts, this field bridges the gap between basic science and patient care, offering crucial insights into everything from infections to cancer.
On Gist.Science, we track every new preprint in this vital area as it appears on bioRxiv and medRxiv. Our team processes these fresh findings to provide both clear, plain-language explanations and detailed technical summaries, ensuring that complex discoveries are accessible to everyone. Below are the latest pathology papers we have summarized from these leading servers.
This study analyzes the pathological findings and causes of death in 316 stranded cetaceans in the Canary Islands from 2013 to 2018, revealing that natural causes (73.6%) predominated over anthropogenic factors (12.9%) while documenting novel disease patterns and reaffirming established mortality trends to support conservation strategies.
This study reports the first successful development of fluorescently labelled strains of the pyrethrum pathogens *Didymella tanaceti* and *Stagonosporopsis tanaceti* via *Agrobacterium*-mediated transformation, enabling the first detailed visualisation of *D. tanaceti*'s infection biology and its co-infection dynamics with *S. tanaceti* within host tissues.
This study demonstrates that even in acute *Plasmodium vivax* malaria, the spleen harbors approximately 89% of the total parasite biomass and acts as a critical regulator of systemic inflammation and disease intensity, whereas its absence leads to higher circulating parasitemia but paradoxically lower total parasite load and altered inflammatory responses.
This study demonstrates that angiotensin II infusion, but not norepinephrine-induced hypertension, exacerbates aortic pathology and induces lethal dissections and branch aneurysms in Fbn1C1041G/+ mice, indicating that angiotensin II drives disease progression through mechanisms beyond simple blood pressure elevation.
This study of 2,800 respiratory specimens in Quzhou, China, from late 2023 to mid-2024 reveals that influenza virus, *Streptococcus pneumoniae*, and adenovirus are the dominant pathogens causing acute respiratory infections, with infection rates varying significantly by age, season, and region, thereby highlighting the need for continuous multi-pathogen surveillance and integrated prevention strategies in the post-pandemic era.
This study demonstrates that chemotherapy-treated Wilms tumours retain distinct spatial gradients of progenitor and cancer stem cell-associated markers within viable blastemal foci, suggesting the persistence of a therapy-resistant stem cell niche that may drive tumour relapse.
A 2022/23 retrospective study of English NHS trusts reveals that poor compliance with the recommended four-hour pre-analytical delay for blood cultures is significantly linked to laboratory centralization, highlighting an urgent need for investment to improve sepsis management and antimicrobial stewardship.
This study demonstrates that cross-modal training using Xenium spatial transcriptomics data enables a DINO-DETR deep learning model to accurately detect and quantify vascular niches in routine H&E whole-slide images, revealing that high AI-derived vascular cell proportions serve as an independent prognostic indicator for worse survival in astrocytoma patients.
This study reveals that four-week exposure to 3.2 GHz pulsed electromagnetic radiation induces sex-specific pathological pathways in mice, causing severe reproductive impairment in males and neurobehavioral deficits in females, supported by distinct circulating protein biomarkers for each sex.
This study employs comparative genomics and functional network analysis to identify and characterize *Colletotrichum sublineola* effectors lacking conserved domains, mapping their interactions within key plant immune subsystems to elucidate the mechanisms of sorghum anthracnose pathogenicity.