39 papers
Pathology is the study of how diseases change the body, uncovering the hidden causes of illness and how they progress. From examining tissue samples to understanding molecular shifts, this field bridges the gap between basic science and patient care, offering crucial insights into everything from infections to cancer.
On Gist.Science, we track every new preprint in this vital area as it appears on bioRxiv and medRxiv. Our team processes these fresh findings to provide both clear, plain-language explanations and detailed technical summaries, ensuring that complex discoveries are accessible to everyone. Below are the latest pathology papers we have summarized from these leading servers.
This study establishes an eight-week chronic UV-exposure model in SKH-1 hairless mice to comprehensively characterize the progressive mechanisms of photoaging, revealing significant skin barrier dysfunction, extracellular matrix remodeling, and altered adipogenesis as key pathological features.
This study demonstrates that while a VGG16-based AI model achieves perfect accuracy in classifying gastrointestinal tissues using specialized stains, it fails to diagnose liver conditions due to insufficient training data, highlighting the critical importance of dataset size for reliable AI-driven digital pathology in resource-limited settings.
This paper presents an optimized, rapid three-minute Hematoxylin and Oil Red O (H-ORO) staining protocol for frozen zebrafish sections that effectively visualizes nuclear and lipid-rich structures while preserving tissue integrity and minimizing artifacts associated with traditional ethanol-based methods.
This study reveals that myeloperoxidase (MPO) drives pulmonary fibrosis by post-translationally inhibiting the collagen-degrading enzyme cathepsin K, thereby shifting the lung toward excessive extracellular matrix accumulation and correlating elevated MPO levels with poor patient outcomes.
Cardiomyocyte-specific deletion of the m6A methyltransferase METTL14 triggers myocarditis and dilated cardiomyopathy by disrupting mitochondrial integrity and autophagy, which leads to RIPK1 accumulation, hyperactivation of type I interferon signaling, and necroptosis.
This study demonstrates that computational analysis of routine Masson-Goldner Trichrome-stained histopathological images can accurately quantify collagen architecture in breast tumors with significant concordance to specialized Second Harmonic Generation microscopy, offering a scalable and clinically accessible alternative for assessing extracellular matrix organization.
This study analyzes the pathological findings and causes of death in 316 stranded cetaceans in the Canary Islands from 2013 to 2018, revealing that natural causes (73.6%) predominated over anthropogenic factors (12.9%) while documenting novel disease patterns and reaffirming established mortality trends to support conservation strategies.
This study reports the first successful development of fluorescently labelled strains of the pyrethrum pathogens *Didymella tanaceti* and *Stagonosporopsis tanaceti* via *Agrobacterium*-mediated transformation, enabling the first detailed visualisation of *D. tanaceti*'s infection biology and its co-infection dynamics with *S. tanaceti* within host tissues.
This study demonstrates that even in acute *Plasmodium vivax* malaria, the spleen harbors approximately 89% of the total parasite biomass and acts as a critical regulator of systemic inflammation and disease intensity, whereas its absence leads to higher circulating parasitemia but paradoxically lower total parasite load and altered inflammatory responses.
This study demonstrates that angiotensin II infusion, but not norepinephrine-induced hypertension, exacerbates aortic pathology and induces lethal dissections and branch aneurysms in Fbn1C1041G/+ mice, indicating that angiotensin II drives disease progression through mechanisms beyond simple blood pressure elevation.