4 papers
This study demonstrates that XGBoost models, interpreted via SHAP, can accurately and reliably predict the need for medical care following toxin exposure using only initial poison control center call data, offering a promising tool to support expert triage decisions.
This prospective single-arm clinical trial demonstrates that a proactive management framework focused on preserving toxin elimination through sustained hydration, octreotide-induced suppression of enterohepatic circulation, and early silibinin administration achieves a 98.8% transplant-free recovery rate in amatoxin-induced acute liver failure.
This study demonstrates that a reproducible postmortem metabolomic fingerprint, identified via high-resolution mass spectrometry in a national cohort of 51 fatal insulin intoxications, can reliably distinguish insulin-induced deaths from other causes even after insulin degradation, offering a valuable complementary tool for forensic diagnosis.
This study utilizes metabolomics to demonstrate that maternal smoking during pregnancy induces persistent alterations in placental metabolic pathways, including disrupted amino acid metabolism and oxidative stress markers, which remain evident even in pregnancies where smoking was discontinued after the first trimester.