367 papers
This study demonstrates that immune checkpoint therapy drives the maturation of a specific "immunity-promoting" cellular neighborhood nucleated by T cell-APC triads, which undergoes spatiotemporal compartmentalization to sustain and amplify cytotoxic T cell responses for effective tumor rejection.
This study presents an optimized 27-color, three-laser spectral flow cytometry panel capable of simultaneously profiling 16 distinct immune and non-immune cell subsets across diverse mouse tissues, successfully demonstrating its utility in tracking dynamic cellular shifts and identifying novel cell populations in a poly(I:C) model.
This study demonstrates that *Francisella tularensis* suppresses Aim2 inflammasome activation and subsequent proinflammatory cytokine secretion by utilizing its antioxidant regulator OxyR to modulate the host macrophage's redox environment, thereby preventing the necessary oxidative signaling for immune defense.
This study reveals that *Mycobacterium tuberculosis* promotes pathogenesis by inducing mitochondrial dysfunction and restricting oxidative phosphorylation in the early lung, whereas maintaining robust mitochondrial metabolism is essential for generating protective immune responses.
This study demonstrates that while both an immunotoxin and an antibody-drug conjugate targeting HIV-infected cells ultimately induce cell death, they exhibit distinct temporal metabolic and transcriptional responses, with the immunotoxin triggering rapid stress and apoptosis pathways compared to the delayed effects of the antibody-drug conjugate.
This study utilizes transcriptomic timeseries analysis in a murine model of enteric infection to demonstrate that the liver coordinates and limits the duration of the systemic acute-phase response through an early, self-limited pulse of gene expression that resolves before the peak of disease.
This study demonstrates that Dengue serotype-1 virus-like particles produced in HeLa cells exhibit native morphology and successfully elicit robust, specific antibody responses in mice, highlighting their potential as a vaccine candidate and serodiagnostic tool.
This study demonstrates that phagocytic clearance of SARS-CoV-2 RNA- and nucleocapsid-containing immune complexes by monocytes drives inflammatory cytokine production and endothelial dysfunction, suggesting that this IgG-mediated mechanism contributes to severe COVID-19 pathology and potentially the severity of other viral infections.
This study reveals that mucosal natural killer (NK) cells play a dual role in barrier immunity by not only controlling viral infections but also directly mediating tissue protection and repair through the expression of amphiregulin, which is induced by inflammatory cytokines IL-18 and IL-33.
This study demonstrates that CRISPR-Cas9-mediated knockout of upregulated ULBP ligands (ULBP2/5/6) in universal CAR-T cells prevents NKG2D-mediated natural killer cell rejection, thereby enhancing their persistence and antitumor efficacy without compromising T cell function.
This study demonstrates that Fc-mediated effector functions, particularly ADCC and ADCVI enhanced by specific glycoengineering, significantly contribute to SARS-CoV-2 viral control by both neutralizing and non-neutralizing antibodies, suggesting their potential value in combating immune-evasive variants.
This paper proposes and validates a novel Imaris-based pipeline for rigorously tracking and characterizing 3D PET-defined lung inflammation sites in *Mycobacterium tuberculosis*-exposed non-human primates, offering superior alignment, automated segmentation, and detailed morphological metrics compared to traditional 2D slice-based analysis methods.
This study demonstrates that neutrophil swarming can be reprogrammed through prior microbial exposure or genetic enhancement of 5-lipoxygenase to improve chemoattractant signaling and ultimately enhance infection clearance in zebrafish.
This study identifies the gut microbiome as a critical environmental driver of heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by demonstrating that microbial dysbiosis activates the IL-1 signaling pathway, thereby promoting bone formation in ACVR1R206H mutation carriers.
This study reveals that overlapping MHC class I/II epitopes drive monocyte-derived dendritic cells to adopt a cDC1-like phenotype capable of initiating type 1 immunity by inhibiting mTORC1 signaling, a mechanism that enhances the efficacy of clinical vaccine products and offers new avenues for cancer immunotherapy.
This study identifies the basophil-specific GPCR Mrgpra6 as a critical regulator of type 2 immunity that mediates effective host defense against helminth infections by controlling early innate responses and shaping the basophil transcriptional landscape.
This study reveals that successful dendritic cell vaccines require sustained in-situ TNFα secretion by tumor-infiltrating myeloid cells to license cytotoxic CD8+ T cells, addressing the current limitation where vaccine-induced TNF expression rapidly declines after tumor infiltration.
This study identifies circulating miR-29a-3p as a promising biomarker for acute food-induced anaphylaxis and demonstrates its regulatory role in maintaining endothelial glycocalyx integrity, specifically through the modulation of ESM1 expression.
This study identifies minoxidil hydrochloride as a potent inhibitor of the NLRP3 inflammasome that functions by upregulating AMPK-mediated autophagy to suppress inflammatory responses in both cell cultures and mouse models.
This study presents MS2.87-97, a cost-effective and durable virus-like particle-based immunotherapy that selectively targets myostatin to increase muscle mass and strength while reducing adiposity in mice, offering a promising alternative to monoclonal antibodies for treating obesity and sarcopenia without observed cardiac safety concerns.