162 papers
Immunology explores the intricate defense systems that keep our bodies safe from infections and disease. This field examines how our immune cells recognize threats, coordinate responses, and maintain a delicate balance between fighting invaders and avoiding self-harm. From understanding vaccine mechanisms to investigating autoimmune disorders, these studies reveal the dynamic biology protecting human health every day.
On Gist.Science, we ensure these critical discoveries remain accessible to everyone. We automatically process every new preprint in this category as it appears on bioRxiv, transforming complex research into both plain-language explanations and detailed technical summaries. This approach allows readers to grasp the core findings without getting lost in dense jargon, while still providing the depth needed for scientific inquiry.
Below are the latest immunology papers from bioRxiv, each accompanied by our curated summaries to help you navigate the newest breakthroughs in the field.
This study reveals that antigen recognition triggers reverse MHC class I signaling in dendritic cells, driving the polarization of the Golgi apparatus toward the immunological synapse to enable spatially restricted IL-12 release that preferentially activates T cells with the highest receptor affinity.
This study demonstrates that H3N2 influenza is cleared from the peripheral organs of 10-day chicken embryos via RIG-I-independent innate immunity and macrophage activity, while the virus persists in the brain due to immune privilege rather than intrinsic neurotropism.
This study reveals that cGAS-STING signaling acts as a dual regulator of osteoclastogenesis by directly suppressing macrophage differentiation and indirectly inhibiting bone resorption through osteoblast-derived IFN-β, which shifts the OPG-RANKL axis toward increased osteoprotegerin production.
This study evaluates the therapeutic potential of NF1-derived single amino acid variants as HLA-A*02:01 neoantigens by combining computational prediction with experimental validation in U87-MG cells, revealing that while only a fraction of predicted candidates are endogenously presented, the findings support the feasibility of NF1-targeted immunotherapies while highlighting the critical need for experimental verification to overcome limitations in current in silico prediction models.
By replaying over a hundred monoclonal germinal center reactions on a quantified affinity landscape, this study reveals that predictable antibody affinity maturation results from noisy but persistent selection constrained by somatic hypermutation biases, while demonstrating that common observations like permissiveness to low-affinity lineages are artifacts of survivorship bias.
The study reveals that *Coxiella burnetii* evades immune clearance in murine macrophages by utilizing a tetra-acylated lipid A structure to avoid activating the non-canonical inflammasome, while also demonstrating that oxygen limitation can suppress NLRP3 inflammasome activation.
This study demonstrates that an autologous cell-based therapeutic vaccine engineered to express an IL-6/IL-1 fusokine drives robust anti-tumor immunity and significantly improves survival in a pre-clinical mouse model of ovarian cancer by enhancing T cell survival, proliferation, and memory responses.
This study presents a high-resolution single-cell atlas of the human B cell compartment across 10 tissues, revealing tissue-specific differentiation trajectories, functional adaptations, and microenvironmental interactions that reshape our understanding of humoral immunity beyond peripheral blood.
This study demonstrates that natural microbial exposure in wildlings selectively suppresses epithelial tuft cell responsiveness to type 2 immune signals via short-chain fatty acids, thereby constraining the anti-helminth "weep and sweep" response in a way that is not observed in standard laboratory mice.
This study establishes a standardized mixed lymphocyte reaction platform to demonstrate that adipose-derived mesenchymal stromal cells exhibit superior immunosuppressive potency compared to bone marrow-derived cells, a function mechanistically driven by the modulation of HLA-DR and a PD-1/PD-L2 signaling axis that inversely correlates with T cell proliferation.