370 papers
This study identifies circulating miR-29a-3p as a promising biomarker for acute food-induced anaphylaxis and demonstrates its regulatory role in maintaining endothelial glycocalyx integrity, specifically through the modulation of ESM1 expression.
This study identifies minoxidil hydrochloride as a potent inhibitor of the NLRP3 inflammasome that functions by upregulating AMPK-mediated autophagy to suppress inflammatory responses in both cell cultures and mouse models.
This study presents MS2.87-97, a cost-effective and durable virus-like particle-based immunotherapy that selectively targets myostatin to increase muscle mass and strength while reducing adiposity in mice, offering a promising alternative to monoclonal antibodies for treating obesity and sarcopenia without observed cardiac safety concerns.
This study introduces the PD1 LIRECAP assay, a novel RNA aptamer-based method that quantifies PD1 saturation by PDL1 in clinical tumor samples, demonstrating its technical reproducibility and potential as a superior predictive biomarker for anti-PD1 therapy.
This study reveals that lung adventitial fibroblasts act as a supportive niche for type 2 regulatory T cells, and that modulating fibroblast TGF-beta signaling can enhance this interaction to improve lung functional outcomes following influenza infection by balancing inflammation and tissue repair.
This study demonstrates that intranasal administration of anti-CD3 monoclonal antibodies attenuates post-COVID neuroinflammation and restores hippocampal neurogenesis and cognitive function in mice by reprogramming microglia and expanding regulatory T cells, suggesting a promising noninvasive therapeutic strategy for Long COVID-related cognitive impairment.
This study demonstrates that inflammatory cytokines associated with skin diseases and severe COVID-19 upregulate viral entry receptors (ACE2 and TMPRSS2) in human skin models, thereby significantly enhancing SARS-CoV-2 susceptibility and suggesting the skin is a previously underappreciated potential entry point for the virus.
This study utilizes a longitudinal, stability-aware framework to demonstrate that cladribine and ocrelizumab induce distinct, non-overlapping microRNA response signatures in multiple sclerosis patients, reflecting their divergent immunological mechanisms through coordinated upregulation of specific miRNAs associated with Th17/Treg balance and Wnt signaling for cladribine versus mTOR and NF-κB pathways for ocrelizumab.
This study reveals that human aging impairs humoral immunity by arresting the maturation of CXCL13+ T follicular helper cells at a precursor stage due to reduced expression of transcriptional regulators BACH2 and SOX4, rather than through defects in B cells.
This study demonstrates that adjuvant formulations containing glucopyranosyl lipid adjuvant (GLA) induce plastic Th17 cells to convert into polyfunctional Th1 memory cells, thereby providing robust protection against fungal infections in mice.
This study demonstrates that urinary complement protein signatures, which are independent of plasma levels and associated with short-term mortality, serve as effective biomarkers for distinguishing severe alcohol-associated hepatitis from alcohol cirrhosis while offering insights into liver-kidney crosstalk mechanisms in alcohol-associated liver disease.
This study establishes that the postnatal maturation of dendritic epidermal T cells and Langerhans cells in mice follows distinct, independent differentiation trajectories that are neither dependent on microbial colonization nor on the presence of canonical T cells.
This study demonstrates that chronic HIV persistence drives accelerated systemic immune aging in treated individuals, a process that is partially modulated by specific antiretroviral agents, particularly nucleoside reverse transcriptase inhibitors.
This retrospective study of 376 adults with newly diagnosed Crohn's disease identifies lower BMI, lower HDL-C, and higher triglycerides as independent metabolic drivers associated with increased disease activity and a higher risk of complications, demonstrating that models using these specific parameters outperform ratio-based approaches in predicting clinical outcomes.
This study identifies fully human monoclonal antibodies, specifically W010 and W014, that target unique epitopes on the West Nile virus envelope protein to provide potent pre- and post-exposure protection against West Nile and related orthoflaviviruses, offering promising candidates for antibody-based interventions.
This study integrates single-cell and spatial multi-omics to construct a comprehensive atlas of human lymph nodes, revealing that aging drives a stepwise shift in senescent cell localization toward germinal centers and induces focal clonal-like senescence in B cells, thereby contributing to age-related immune decline.
This study reveals that the MLL1-MENIN complex preserves CD8 T cell memory through a noncanonical, methyltransferase-independent mechanism that sustains the TOX-BTLA-TCF1 axis to restrain cytokine-driven AKT activation and prevent the loss of stem cell-like memory potential.
This study presents a comprehensive human neonatal CITE-seq atlas that reveals a critical immune transition at 32 weeks' gestation, shifting from a CD15+ myeloid-dominated state in extremely preterm infants to an interferon-primed immunity in more mature neonates, thereby defining gestational age-specific immune programs and vulnerabilities.
This study utilizes high-resolution mass spectrometry to map the extensive proteomic remodeling of B cells during activation, revealing how mTORC1, MYC, and iron availability coordinately regulate metabolic machinery, amino acid transport, and cellular growth to drive protein production.