258 papers
Immunology explores the intricate defense systems that keep our bodies safe from infections and disease. This field examines how our immune cells recognize threats, coordinate responses, and maintain a delicate balance between fighting invaders and avoiding self-harm. From understanding vaccine mechanisms to investigating autoimmune disorders, these studies reveal the dynamic biology protecting human health every day.
On Gist.Science, we ensure these critical discoveries remain accessible to everyone. We automatically process every new preprint in this category as it appears on bioRxiv, transforming complex research into both plain-language explanations and detailed technical summaries. This approach allows readers to grasp the core findings without getting lost in dense jargon, while still providing the depth needed for scientific inquiry.
Below are the latest immunology papers from bioRxiv, each accompanied by our curated summaries to help you navigate the newest breakthroughs in the field.
This study identifies NimB2 as a secreted opsonin produced by the *Drosophila* fat body that promotes resistance to *Staphylococcus aureus* by recognizing bacterial lipoteichoic acid and facilitating its uptake by macrophages via the Eater receptor.
This study demonstrates that a heterologous prime-boost strategy using a recombinant *Mycobacterium smegmatis* expressing Ag85B and ESAT-6, particularly when adjuvanted with oat-derived -glucan, significantly enhances BCG-induced immunity to achieve complete systemic clearance of *Mycobacterium tuberculosis* in mice, outperforming repeated BCG vaccination which offers no additional protection.
This study demonstrates that atomic layer deposition (ALD) can be used to coat core-shell microparticle vaccines with a programmable nanoscopic alumina shell, enabling sustained antigen release that significantly enhances germinal center expansion, antibody affinity, and long-lived plasma cell generation compared to traditional bolus vaccination.
This study uses mechanistic modeling to demonstrate that the expansion sensitivity of CD8+ T cells provides the underlying biological basis for why high levels of Ki-67+ and TCF-1+ cells predict successful post-treatment control of HIV by establishing lower viral set points.
This study reveals that apoptotic caspases cleave the mitochondrial fission factor DRP1 during viral infection to induce mitochondrial elongation and MAVS aggregation, thereby enhancing anti-viral immune responses.
This study presents the cryo-EM structure of duck secretory IgM, revealing a conserved pentameric core similar to mammals while highlighting avian-specific interface features that facilitate unique secretory component interactions essential for mucosal immunity.
This study demonstrates the utility of an mRNA-immunised pig model for isolating novel Nipah virus neutralising monoclonal antibodies that target distinct epitopes on the G glycoprotein, with a specific candidate (mAb A2) showing enhanced therapeutic potential when combined with the existing standard mAb m102.4 to achieve complete protection against lethal viral challenge.
This study demonstrates that replacing cesium-137 with X-ray irradiation in bone marrow chimera models yields comparable immune reconstitution, cell distribution, and activation states, thereby validating X-ray systems as a safe and effective alternative for immunological research.
This study reveals that the immunomodulatory efficacy of the antidepressant fluoxetine in macrophages is critically dependent on the cellular lipid landscape, as disruptions in lipid metabolism or exposure to oxidized lipids can reverse its anti-inflammatory effects, offering a potential mechanism for treatment-resistant depression.
This study demonstrates that despite recognizing non-polymorphic CD1b molecules, both invariant and diverse CD1b-specific T cells exhibit adaptive transcriptional features that align them more closely with conventional T cells than with innate-like populations such as NKT, MAIT, and γδ T cells.