370 papers
This study reveals that diverse extracellular bacterial pathogens commonly utilize the lymphatic system to disseminate from soft tissue infections to sequential draining lymph nodes and systemic organs, challenging the traditional view that lymph nodes primarily function to trap and eliminate such bacteria.
This study demonstrates that activating PPAR beta delta in human mesenchymal stromal cells enhances their therapeutic efficacy in a pre-clinical model of acute lung inflammation by inducing the secretion of ANGPTL4, which mediates anti-inflammatory, reparative, and cytoprotective effects.
This study demonstrates that neutrophil Fc gamma RI expression is a critical determinant of reactive oxygen species production in both healthy individuals and lupus patients, suggesting it as a promising therapeutic target for modulating oxidative responses.
This study demonstrates that specific circulating immune cell populations are associated with nociplastic (non-inflammatory) pain in rheumatoid arthritis patients who have minimal joint inflammation, offering new insights into the cellular mechanisms underlying altered central pain regulation.
This study demonstrates that pharmacological inhibition of DPP-4, using the FDA-approved drug sitagliptin, enhances anti-tumor CD8+ T cell responses by upregulating GAD1 to improve metabolic fitness, thereby prolonging survival in glioblastoma models and improving outcomes in patients.
This study demonstrates that the SJL mouse strain, unlike C57BL/6, exhibits accelerated and robust SEZ6L2-directed immune responses—including enhanced antibody production, T-cell activation, and CNS lymphocyte infiltration—that correlate with motor deficits, thereby establishing a superior model for investigating the coordinated immune mechanisms underlying SEZ6L2 autoimmunity and neurological dysfunction.
This study reveals that while early glycolysis is dispensable for human Tfh cell differentiation, it is essential for their functional capacity by driving a fatty acid metabolic axis that regulates critical helper functions like IL-21 and IFN-γ production.
This study demonstrates that biocompatible membrane vesicles derived from *Lactobacillus acidophilus* MTCC 10307, potentially mediated by surface-layer protein A (SlpA), exhibit potent anti-inflammatory activity by suppressing pro-inflammatory mediators in macrophages and resolving edema in vivo without causing adverse toxic effects.
This study demonstrates that both chronic exercise and dietary energy density drive segment-specific intestinal remodeling and distinct transcriptional adaptations in immune and stress pathways, revealing that habitual physical activity induces an adaptive state that buffers the gut against acute nutritional stress and excessive immune activation.
This study demonstrates that mature villus-like enterocytes in the human intestinal epithelium are the primary sensors of enterovirus infection, utilizing TLR3 signaling to drive localized type III interferon responses that help restrict viral spread.
This study demonstrates that epithelial MHCII, rather than immune cell MHCII, is essential for initiating and sustaining autoimmunity-driven gastric tumorigenesis by promoting stem-like, immune-evasive differentiation, and that removing this factor can reverse early premalignancy.
This study demonstrates that machine learning-guided selection of conserved non-spike T-cell targets enables the development of multiepitope mRNA vaccines capable of eliciting robust, broad-spectrum T-cell immunity against diverse coronaviruses, offering a scalable alternative to spike-focused approaches.
This study utilizes single-cell RNA sequencing to establish a comprehensive transcriptomic atlas of equine blood dendritic cells, confirming known subsets while identifying novel transitional and type 3 populations, and demonstrating their conservation across species to advance the understanding of equine immune responses.
This study identifies CEA, DLL3, and GFRA4 as promising targets for T cell engagers in medullary thyroid cancer, demonstrating that the resulting bispecific antibodies effectively induce T cell-mediated cytotoxicity and show enhanced efficacy when combined with tyrosine kinase inhibitors in preclinical models.
This study reveals that susceptibility to vulvovaginal candidiasis is driven by a synergistic IL-1, IL-17, and IL-22 cytokine circuit that controls fungal infection independently of estrogen, challenging the prevailing paradigm that hormonal pathways are the primary determinant of disease.
This study identifies soluble LAG-3 (sLAG-3) as a novel early biomarker of autoreactive T cell activation that precedes islet autoantibody development in Type 1 diabetes, offering potential for improved risk stratification and earlier intervention in genetically susceptible individuals.
This prospective cohort study demonstrates that among people with chronic HIV, those diagnosed late (with CD4+ counts <350 cells/mm³ or AIDS-defining illnesses) exhibit a significantly larger inducible viral reservoir and greater CD8+ T cell exhaustion one year after starting antiretroviral therapy compared to those diagnosed earlier in the chronic stage, underscoring the critical importance of early diagnosis even before the acute phase concludes.
This study utilizes multimodal single-cell profiling of human pancreatic lymph nodes to reveal that type 1 diabetes development is characterized by an enrichment of stem-like CD8+ T cells driven by IL-15 signaling, which share clonal features with pancreatic effector cells that exhibit distinct activation and exhaustion phenotypes near the islets.
Cigarette smoke exposure establishes a pro-inflammatory circuit in the lung that recruits and hyper-activates autoreactive T helper cells, thereby amplifying their encephalitogenic potential and increasing the risk of multiple sclerosis.
This study establishes a novel human iPSC-derived co-culture system where direct contact between macrophages and hepatocytes drives reciprocal maturation into Kupffer cell-like and functional hepatocyte phenotypes, creating a physiologically relevant model for investigating liver biology and immune-mediated drug toxicity.