258 papers
Immunology explores the intricate defense systems that keep our bodies safe from infections and disease. This field examines how our immune cells recognize threats, coordinate responses, and maintain a delicate balance between fighting invaders and avoiding self-harm. From understanding vaccine mechanisms to investigating autoimmune disorders, these studies reveal the dynamic biology protecting human health every day.
On Gist.Science, we ensure these critical discoveries remain accessible to everyone. We automatically process every new preprint in this category as it appears on bioRxiv, transforming complex research into both plain-language explanations and detailed technical summaries. This approach allows readers to grasp the core findings without getting lost in dense jargon, while still providing the depth needed for scientific inquiry.
Below are the latest immunology papers from bioRxiv, each accompanied by our curated summaries to help you navigate the newest breakthroughs in the field.
This study demonstrates that an intranasal booster vaccine utilizing a synthetic consensus spike protein (SarbConS) delivered with ferritin nanoparticles and a specific adjuvant elicits durable, cross-protective mucosal IgA responses that are essential for defending against diverse zoonotic Betacoronaviruses, including SARS-CoV-2 and MERS-CoV.
This study reveals that the keystone pathogen *Porphyromonas gingivalis* promotes periodontitis progression by enhancing the survival of commensal *Streptococcus gordonii* within macrophages, which triggers NLRP6 inflammasome activation and subsequent IL-1β-mediated alveolar bone loss.
This study demonstrates that hepatic γδ NKT cells are essential for inducing protective liver-resident CD8+ T cell responses against malaria parasites following vaccination with attenuated Plasmodium, a mechanism confirmed by identifying similar activated γδ T cell correlates of protection in human clinical trial participants.
This study demonstrates that systemic LPS administration in female BALB/c mice triggers a coordinated sickness state characterized by peripheral inflammation, hepatic metabolic and redox alterations, region-specific neuronal and microglial activation, and distinct thermoregulatory, feeding, and behavioral changes across acute and resolving phases.
By integrating matched proteomic and transcriptomic profiling of CD8+ T cells from non-small cell lung cancer patients, this study identifies the chromatin remodeler CHD4 and fatty acid synthase (FASN) as critical, protein-level regulators of T cell functionality that are not detectable through transcriptomic analysis alone.
This study identifies a novel *T. brucei* surface protein that evades complement-mediated killing by binding Factor B and structurally disrupting the C3bBb convertase, thereby inhibiting the amplification of the complement cascade.
This study reveals that peripheral inflammation triggers macrophage-mediated atrophy of perinodal fat pads, thereby releasing essential nutrients to fuel the expansion of embedded lymph nodes and support the energetic demands of the adaptive immune response.
This study identifies a specific intrathecal antibody signature in a subset of multiple sclerosis patients that targets an Epstein-Barr virus BRRF2 motif and cross-reacts with human CNS antigens, suggesting a molecular link between EBV infection and MS pathogenesis while offering a potential biomarker for disease stratification.
This study demonstrates that the anatomical site of HIV-1 vaccine boosting critically determines secondary B-cell fates, with ipsilateral injections preferentially engaging antigen-specific memory clones for continued affinity maturation while contralateral injections recruit cells with no prior antigen exposure or off-target cells biased toward plasma cell differentiation.
This study reveals that in human macrophages, glucose metabolism drives a feedback loop where LPS-induced upregulation of the glycolytic enzyme PFKFB3 is essential for activating the STAT1/NF-κB/IRF5 signaling axis, thereby coordinating both inflammatory and antiviral immune responses.