🛡️ Category

immunology

311 papers

Immunology explores the intricate defense systems that keep our bodies safe from infections and disease. This field examines how our immune cells recognize threats, coordinate responses, and maintain a delicate balance between fighting invaders and avoiding self-harm. From understanding vaccine mechanisms to investigating autoimmune disorders, these studies reveal the dynamic biology protecting human health every day.

On Gist.Science, we ensure these critical discoveries remain accessible to everyone. We automatically process every new preprint in this category as it appears on bioRxiv, transforming complex research into both plain-language explanations and detailed technical summaries. This approach allows readers to grasp the core findings without getting lost in dense jargon, while still providing the depth needed for scientific inquiry.

Below are the latest immunology papers from bioRxiv, each accompanied by our curated summaries to help you navigate the newest breakthroughs in the field.

🛡️ immunology

Spatiotemporal profiling of T cell repertoires in Lynch syndrome reveals convergent immune responses through neoplastic progression

This study utilizes dense spatiotemporal profiling of T cell receptor repertoires in Lynch syndrome patients to demonstrate that neoplastic progression drives convergent, antigen-driven immune responses characterized by conserved T cell clones that persist in both colonic tissue and peripheral blood, offering a framework for early immune monitoring and biomarker development.

Edwards, P., Swinyard, O., Ronel, T., Jiang, Y., Nageswaran, G., Sakr, C., Yasmin, S., Grant, H., Smith, E., Braeutigam (…)2026-10-12
🛡️ immunology

Fast receptor-antigen dissociation kinetics promote CAR-T cell tumor infiltration, functional fitness, and antitumor efficacy in solid tumors

This study demonstrates that engineering CAR-T cells with fast receptor-antigen dissociation kinetics, rather than high-affinity binding, significantly enhances tumor infiltration, preserves functional fitness by preventing exhaustion, and improves antitumor efficacy against established solid tumors.

Mao, R., Shi, H., Hussein, M. S., Karia, B., Koomson, O., Sadek, R., Kota, V., Gascoigne, N., He, Y.2026-10-12
🛡️ immunology

Robust V(D)J Recombination in the Absence of SA1/2-mediated Chromatin Loops

This study demonstrates that while SA1 and SA2 are required to maintain genome-wide chromatin loops and long-range Igh V(D)J recombination in G0/G1-arrested cells, robust Ig{kappa} V(D)J recombination persists in their absence due to unimpeded loop extrusion driven by strong recombination signal sequences.

Yang, Z., Fu, Y., Mikhova, M., Chen, D., Hebert, C., Ye, A. Y., Lin, X., Williams, T., Hu, H., Ba, Z., Dekker, J., Alt (…)2026-10-11
🛡️ immunology

Tolerance to Lung Infection in TWIK2 K+ Efflux Mediated Macrophage Trained Immunity

This study reveals that extracellular ATP induces trained immunity in alveolar macrophages by activating the P2X7 receptor to translocate TWIK2 channels to the plasma membrane, where they subsequently facilitate NLRP3 inflammasome activation and phagosomal bacterial killing through dual mechanisms of potassium efflux and influx.

Thompson, J., Li, Y., Song, Y., Kim, K.-W., Malik, A., Xu, J.2026-10-09
🛡️ immunology

Ethmoid bone marrow region modulates lymphoid activation and differentiation with distinct myeloid profile in neuroinflammation

This study utilizes scRNAseq and flow cytometry to demonstrate that the cribriform plate bone marrow within the ethmoid bone acts as a distinct immune niche that senses neuroinflammation and modulates lymphoid activation and differentiation through a unique myeloid profile, suggesting its potential as a therapeutic target for neuroinflammatory diseases.

Laaker, C. J., Kovacs, K. G., Herbath, M., Vi, K., Port, J., Vrba, S. M., Ordonez, S. F. W., Coogan, S., Priyathilaka, T (…)2026-10-08
🛡️ immunology

Circadian and Sex-Specific Responses to Alternaria alternata in Allergic Airway Inflammation

This study demonstrates that the severity and cellular composition of *Alternaria alternata*-induced allergic airway inflammation in mice are governed by a complex interplay of circadian timing and sex, with females exhibiting peak inflammatory responses at the start of the active phase and males at the start of the resting phase, suggesting that chronotherapeutic strategies could improve asthma management.

Duraisamy, S. K., Mainzer, J., Prasad, C., Haworth, S., Castro, M., Sundar, I. K.2026-10-07