258 papers
Immunology explores the intricate defense systems that keep our bodies safe from infections and disease. This field examines how our immune cells recognize threats, coordinate responses, and maintain a delicate balance between fighting invaders and avoiding self-harm. From understanding vaccine mechanisms to investigating autoimmune disorders, these studies reveal the dynamic biology protecting human health every day.
On Gist.Science, we ensure these critical discoveries remain accessible to everyone. We automatically process every new preprint in this category as it appears on bioRxiv, transforming complex research into both plain-language explanations and detailed technical summaries. This approach allows readers to grasp the core findings without getting lost in dense jargon, while still providing the depth needed for scientific inquiry.
Below are the latest immunology papers from bioRxiv, each accompanied by our curated summaries to help you navigate the newest breakthroughs in the field.
This study demonstrates that targeting myeloid cells in glioblastoma with ABCA1 siRNA-loaded lipid nanoparticles reprograms cholesterol metabolism to enhance antigen presentation and unleash anti-tumor immunity, effectively overcoming therapy resistance in immunologically cold tumors.
This study demonstrates that personalized neoantigen vaccines synergize with immune checkpoint inhibitors and CD8-targeted cytokines to overcome T-cell dysfunction and achieve durable systemic elimination of B-cell lymphoma in both local and disseminated murine models.
This study demonstrates that in a mouse model of type 1 diabetes, the loss of SAP protein protects against disease by suppressing pro-inflammatory anti-insulin B cell activation and subsequent CD8+ T cell-mediated islet destruction, while notably preserving T follicular helper cell responses and extrafollicular antibody immunity.
This study demonstrates that the LiteVax adjuvant enhances influenza vaccine immunogenicity in older adults by inducing a transient interferon-driven innate response that accelerates early IgG3 production and improves T-cell memory differentiation, thereby mitigating age-related immune decline.
This study demonstrates that engineering T cell receptors to form force-induced catch bonds, rather than pursuing high-affinity maturation, significantly enhances sensitivity and therapeutic efficacy against solid tumors while avoiding off-target toxicities by leveraging mechanosensory properties to improve antigen recognition and signaling.
This study reveals that Gelsolin acts as a critical safeguard against psoriasis-like dermatitis by directly binding imiquimod to mitigate ER stress-driven inflammatory circuits, which otherwise amplify IL-23 and NLRP3 signaling through ER-mitochondria contact sites and a feed-forward loop involving extracellular mtDNA and antimicrobial peptides.
This study demonstrates that a prime-and-pull vaccination strategy, combining subcutaneous BCG with mucosal mRNA delivery, effectively induces protective lung immunity against tuberculosis while maintaining the safety profile of parenteral administration.
The study introduces a modular dual stimulatory receptor (DSR) that synchronizes costimulatory and cytokine signals to enhance T cell expansion, persistence, and antitumor efficacy in TCR-based immunotherapies.
This study demonstrates that agarikon mycelium exerts a context-dependent, adaptive immune-modulating effect in human cells by selectively engaging innate immune pathways under basal conditions while buffering oxidative stress and preventing cytokine overstimulation during LPS-induced inflammation.
This study identifies novel HLA-A33-restricted CD8+ T cell epitopes from avian influenza A/H5N1, revealing allotype-specific presentation differences and demonstrating that conserved peptides can elicit cross-reactive immunity in HLA-A*33:03-positive individuals, thereby offering promising candidates for the development of broadly protective vaccines.