374 papers
This study demonstrates that autophagy deficiency in splenic red pulp macrophages impairs their ability to manage iron stress and recycle red blood cells, leading to cellular toxicity, splenic enlargement, and exacerbated anemia.
This study demonstrates that in vivo diffusion-weighted magnetic resonance spectroscopy can detect age-related differences and acute IFN-β-induced increases in thalamic choline-containing metabolite diffusivity, providing a non-invasive signature of inflammation-driven glial morphological changes.
This study successfully developed and validated a lumazine synthase nanoparticle-based GnRH mRNA vaccine (GnRH-4) containing five tandem epitopes, which demonstrated potent immunogenicity, long-lasting reproductive suppression, and excellent biosafety in both mouse and cat models, highlighting its potential as a safe and effective alternative to surgical castration.
This study reveals that the abundance of the A20 protein is regulated by phosphorylation-dependent degradation via autophagy, a mechanism uncovered through the discovery of an epistatic interaction between a rare hypomorphic *TNFAIP3* variant and a *TAX1BP1* modifier that normally restrains A20 phosphorylation.
This study reveals that IFIT3 restricts Hepatitis C Virus infection by specifically recognizing and binding to m⁶A-modified viral and host RNAs through distinct structural domains, thereby establishing a novel m⁶A-dependent antiviral mechanism.
This study identifies a conserved subset of CD226+ macrophages derived from MDP-preconditioned monocytes that regulate lipid metabolism homeostasis across multiple tissues, including brown adipose tissue.
This study demonstrates that depleting extracellular asparagine impairs the activation, mitochondrial function, and cytokine production of autoreactive CD4+ T cells, thereby reducing disease severity in murine models of multiple sclerosis and suggesting a novel therapeutic strategy for autoimmunity.
This study utilizes high-dimensional spatial proteomics to comprehensively map and classify 77 distinct cell types within normal human lymph nodes, revealing novel cellular subsets, previously unrecognized spatial niches, and specific cell-cell interaction landscapes.
This study demonstrates that both endogenous and exogenous electrophiles can induce irreversible, non-enzymatic post-translational modifications on antigenic peptides, which reshape the immunopeptidome by altering MHC-I stability and disrupting T cell recognition even when peptide binding is preserved.
By integrating in vitro experiments with mechanistic modeling, this study reveals that the therapeutic efficacy variability of multivalent T cell engagers is governed by the relationship between binding affinity and dosing, providing a quantitative framework to optimize design and dosing strategies.
This study demonstrates that targeted somatic evolution of an inherently cross-reactive IGHV3-53 germline antibody, guided by structural analysis, can restore and enhance neutralization against immune-escaping SARS-CoV-2 Omicron variants, offering a blueprint for engineering resilient antibody responses.
This study characterizes Fireko mice, a novel model with germ-line deletion of the Csf1r enhancer FIRE that selectively depletes specific tissue-resident macrophages while preserving normal development and organ function, thereby providing a unique platform to investigate macrophage roles in homeostasis and disease.
This study demonstrates the generation and structural characterization of high-affinity nanobodies that specifically target MR1-5-OP-RU complexes, proving their ability to inhibit MAIT cell responses and serve as a platform for bispecific T-cell engagers capable of killing both bacterially infected and tumor cells.
This study reveals that hepatic MAIT cells promote tissue repair and liver regeneration by expressing and secreting VEGFA, VEGFB, and vimentin to activate VEGFR2 signaling, thereby stimulating the proliferation of epithelial and endothelial cells.
This study reveals that the cellular targets of IL-17 signaling in inflammatory skin diseases are context-dependent, with dermal fibroblasts acting as the primary mediators in hidradenitis suppurativa-like inflammation while both fibroblasts and keratinocytes contribute to psoriasis-like inflammation.
This study utilizes a genome-wide CRISPR screen with CD86 as a functional readout to identify UBE2L6 as a novel regulator of tolerogenic dendritic cells that promotes immune tolerance by suppressing T cell activation through an ISGylation-dependent pathway.
This study reveals that rare individuals who naturally control HIV rebound after treatment cessation exhibit distinct, early immune signatures characterized by pre-rebound activation and reduced systemic inflammation, suggesting that immunotherapies can similarly induce protective pre-rebound immune responses.
This study demonstrates that HIV-1 infection does not inherently protect CD4+ T cells from cytotoxic T lymphocyte-mediated killing, as observed survival advantages in actively infected cells are primarily due to Nef-dependent downregulation of MHC class I molecules rather than intrinsic resistance to cell death.
This study demonstrates that HDAC1 inhibition in myeloid-derived suppressor cells (MDSCs) upregulates the lncRNA Malat1 to suppress pSTAT3 signaling, thereby inducing apoptosis and cell cycle arrest while reducing the cells' ability to inhibit T cell proliferation.
This study demonstrates that a transient wave of neonatal regulatory T cells is essential for normal alveologenesis by restraining neutrophil-mediated inflammation, thereby preventing structural lung abnormalities and preserving epithelial balance.