212 papers
Immunology explores the intricate defense systems that keep our bodies safe from infections and disease. This field examines how our immune cells recognize threats, coordinate responses, and maintain a delicate balance between fighting invaders and avoiding self-harm. From understanding vaccine mechanisms to investigating autoimmune disorders, these studies reveal the dynamic biology protecting human health every day.
On Gist.Science, we ensure these critical discoveries remain accessible to everyone. We automatically process every new preprint in this category as it appears on bioRxiv, transforming complex research into both plain-language explanations and detailed technical summaries. This approach allows readers to grasp the core findings without getting lost in dense jargon, while still providing the depth needed for scientific inquiry.
Below are the latest immunology papers from bioRxiv, each accompanied by our curated summaries to help you navigate the newest breakthroughs in the field.
This study presents a high-resolution single-cell atlas of the human B cell compartment across 10 tissues, revealing tissue-specific differentiation trajectories, functional adaptations, and microenvironmental interactions that reshape our understanding of humoral immunity beyond peripheral blood.
This study demonstrates that natural microbial exposure in wildlings selectively suppresses epithelial tuft cell responsiveness to type 2 immune signals via short-chain fatty acids, thereby constraining the anti-helminth "weep and sweep" response in a way that is not observed in standard laboratory mice.
This study establishes a standardized mixed lymphocyte reaction platform to demonstrate that adipose-derived mesenchymal stromal cells exhibit superior immunosuppressive potency compared to bone marrow-derived cells, a function mechanistically driven by the modulation of HLA-DR and a PD-1/PD-L2 signaling axis that inversely correlates with T cell proliferation.
This study characterizes the genetic, intrinsic, and environmental determinants of innate immune cytokine responses in 286 healthy four-year-old children, revealing that genetic variants explain a substantial proportion of response variance while systemic inflammation and seasonal viral burdens also significantly influence immune activity.
This study identifies ZC3H12C as a conserved marker of T cell exhaustion and demonstrates that its genetic disruption enhances T cell persistence, expansion, and antitumor efficacy in both TCR and CAR T cell therapies across various cancer models.
This study demonstrates that homologous superimposed *Echinostoma caproni* infection in mice triggers a coordinated proteomic reprogramming of ileal epithelial cells, driven by IL25, which restores intestinal homeostasis through integrated metabolic, barrier, and immune adaptations.
This longitudinal study of ART-suppressed SIV-infected rhesus macaques reveals a biphasic immune remodeling process characterized by an initial acute interferon-driven response that resolves with viral control, followed by late-stage dysregulation involving TGF-beta and NF-kappaB signaling and inflammatory monocyte bursts in the bone marrow, which may underlie non-AIDS complications and reservoir persistence in people living with HIV.
This study demonstrates that CMV replication in AML patients elevates IFNγ levels, which simultaneously upregulates HLA-E on leukemia cells and primes NKG2C-expressing NK cells, thereby enhancing NK-mediated cytotoxicity against AML through the NKG2C-HLA-E axis.
This study demonstrates that CRISPR-engineered, allogeneic CAR-T cells targeting GPC2 and GPC3 antigens, derived from healthy donors, exhibit potent and scalable antitumor efficacy in solid tumor models, supporting their clinical development as an off-the-shelf therapy.
This study demonstrates that the TLR4-targeted adjuvant SMNP, but not MPLA, effectively induces immune activation and indirectly reduces the inducible HIV-1 reservoir in ART-treated individuals ex vivo, supporting its potential for therapeutic vaccination while highlighting the need for further safety evaluation.