212 papers
Immunology explores the intricate defense systems that keep our bodies safe from infections and disease. This field examines how our immune cells recognize threats, coordinate responses, and maintain a delicate balance between fighting invaders and avoiding self-harm. From understanding vaccine mechanisms to investigating autoimmune disorders, these studies reveal the dynamic biology protecting human health every day.
On Gist.Science, we ensure these critical discoveries remain accessible to everyone. We automatically process every new preprint in this category as it appears on bioRxiv, transforming complex research into both plain-language explanations and detailed technical summaries. This approach allows readers to grasp the core findings without getting lost in dense jargon, while still providing the depth needed for scientific inquiry.
Below are the latest immunology papers from bioRxiv, each accompanied by our curated summaries to help you navigate the newest breakthroughs in the field.
This study reveals that the modern, highly regulated NLRP3 inflammasome is unique to eutherian mammals and evolved approximately 160 million years ago, distinct from the NLRP3-like proteins found in non-eutherian vertebrates which lack key structural and regulatory features.
This study reveals that rheumatoid arthritis monocytes possess a stable, disease-intrinsic state characterized by a persistent metabolic-secretory decoupling involving depleted nucleotide and redox metabolites, downregulated mitochondrial and translational pathways, and impaired glycosylation capacity, which remains consistent across various activation conditions.
This study defines the GID/CTLH-dependent ubiquitylome in macrophages and demonstrates that the complex regulates metabolic and innate immune responses to *Mycobacterium tuberculosis* by targeting key inhibitory phosphatases, such as PTEN and INPP5D, for proteasomal degradation.
This study demonstrates that the *Orientia tsutsugamushi* Karp strain induces more severe disease than the Gilliam strain by selectively upregulating proinflammatory signaling and C-type lectin receptors in macrophages while simultaneously exhibiting greater resistance to IFN--mediated killing.
This study demonstrates that an innovative HSV-2 vaccine strategy using nanoparticles displaying both the attachment protein gD and fusion proteins gH/gL elicits complementary immune responses, including fusion-blocking antibodies, which provide robust protection against infection and disease in mice and non-human primates.
This study demonstrates that lupus immune complexes drive distinct pro-inflammatory monocyte and macrophage populations through an ETS2-dependent mechanism independent of type I interferon signaling, identifying these cells as key therapeutic targets for systemic lupus erythematosus.
This paper demonstrates that adapting a token-choice mixture-of-experts (MoE) architecture for antibody language models enables specialized learning of diverse regions like CDRH3, significantly outperforming dense counterparts while accommodating variable sequence lengths through optimized routing.
This study demonstrates that spectral flow cytometry, especially when combined with optimized panel design, outperforms conventional flow cytometry by delivering superior signal-to-noise ratios, enhanced resolution of low-intensity markers, and improved detection of rare T-cell subsets, thereby significantly advancing the robustness of high-parameter immunophenotyping.
This study identifies a pathogenic CXCL12hi APOC1+ senescent iCAF-like fibroblast population that drives therapy-resistant rheumatoid arthritis by creating a supportive niche for plasmablasts via the CXCL12-CXCR4 axis and activating the STAT3-C/EBP pathway, suggesting that targeting these cells could overcome treatment resistance.
This study demonstrates that an oral formulation of Purified Borrelial Lipoproteins combined with a recombinant fusion protein adjuvant (PBL+rCOM) effectively induces durable immunity in mouse and white-footed mouse reservoirs, significantly reducing *Borrelia burgdorferi* burden and blocking transmission to *Ixodes scapularis* ticks.