383 papers
This study identifies that metabolic reprogramming of Th17 cells via the OXPHOS pathway drives LIGHT-mediated airway remodeling in severe mixed granulocytic asthma, demonstrating that dual blockade of OXPHOS and LIGHT effectively reverses disease features and restores regulatory T cell numbers.
This study reveals that heterozygous gain-of-function mutations in STAT1 drive autoimmunity by promoting the differentiation of T follicular helper type 1 cells and excessive IFN-γ production, a mechanism that can be therapeutically targeted by IFN-γ neutralization.
This study demonstrates that mixed hematopoietic chimerism in NOD mice restores immune tolerance by generating donor-derived CD8+CD122+ regulatory T cells that selectively eliminate autoreactive T cells through a perforin/granzyme-B-dependent mechanism, offering a potential therapeutic strategy for Type 1 diabetes given the observed deficiency of these cells in human patients.
This study demonstrates that ImmTACs can overcome cytotoxic T cell suppression by triggering calcium signaling and subcellular polarization to induce tumor cell cytolysis, even though they fail to elicit IFN-gamma secretion under these conditions.
This study demonstrates that osteopontin (OPN), produced by a specific neutrophil subtype during *Staphylococcus aureus* skin infections, is a critical mediator of tissue repair that accelerates lesion healing and reduces lesion size, suggesting its potential as a therapeutic target for improving infection resolution.
This study demonstrates that endotoxemia resulting from gut barrier dysfunction in colitis triggers anemia by activating TLR4 on CD169+ tissue-resident macrophages, a mechanism that can be mitigated by TLR4 inhibition to protect against both inflammation and anemia.
This study utilizes CUT&Tag and transcriptome analysis to map the dynamic H3K27ac chromatin landscape across human MAIT cell development stages, revealing that progressive epigenetic remodeling at enhancers and promoters of key transcription factors and immune-related genes drives the acquisition of effector programs during thymic maturation.
This paper introduces and comprehensively benchmarks immunoPETE, a robust DNA-based assay that enables simultaneous, accurate, and quantitative profiling of B-cell and T-cell receptor repertoires from genomic DNA, demonstrating its utility in predicting clinical outcomes in bladder cancer and its broad applicability across immunology research.
This study demonstrates that two new alternative assays (Single-Molecule Planar ELISA and multiplexed Luminex) offer comparable accuracy to the gold-standard FANG ELISA for measuring Ebola virus antibodies while providing superior performance in terms of lower variability, reduced repeat rates, and higher throughput.
This study reveals that intestinal epithelial cells dynamically encode tissue identity and injury into their MHC II ligandome to maintain homeostasis through regulatory T cell induction and to alert the immune system during inflammation.
This study reveals that adenosine accumulation in aging tissues drives the differentiation of CD8+ T cells into a pro-aging Gzmk+ population via A2aR signaling, creating a feed-forward loop that fuels systemic inflammaging, which can be reversed by targeting this axis to extend healthy lifespan.
This study reports the development and preclinical validation of a DNA-primed, MVA-vectored multivalent vaccine that successfully elicits robust immune responses and confers simultaneous protection against lethal infections from Ebola Sudan, Marburg, and Lassa viruses, offering a streamlined solution for outbreak control in Sub-Saharan Africa.
This study identifies the MIF-CD74 signaling pathway as a novel regulator of trabecular meshwork dysfunction in glaucoma, demonstrating that MIF-mediated suppression of Blimp-1 drives cytoskeletal contractility and extracellular matrix remodeling, which can be therapeutically targeted to restore aqueous humor outflow and reduce intraocular pressure.
This study reveals that transient spatial reorganization of the immune landscape, specifically the segregation of regulatory T cells (Tregs) from initial priming sites, creates a protective window for broad CD8 T-cell recruitment, while subsequent CXCR3-dependent retention prevents activated T cells from relocating to Treg-rich areas where low-affinity clones would otherwise be suppressed by a lack of CD70 costimulation.
This study reveals that AIM2 activates innate immune responses by undergoing DNA-triggered liquid-liquid phase separation to form dynamic condensates that serve as regulatory platforms for inflammasome and PANoptosome assembly, a mechanism essential for immune defense and homeostasis.
This study utilizes an in vivo screening approach in mice to identify novel genetic regulators of Natural Killer cell development and antiviral function against cytomegalovirus, including Synaptotagmin-like protein 3, with findings supported by human genomic data and clinical immunodeficiency cohorts.
This study demonstrates that the lineage-specific metabolic and immunological environments of brain-resident microglia versus infiltrating monocyte-derived macrophages dictate whether *Listeria monocytogenes* adopts a replicative cytosolic lifestyle or enters a stress-tolerant, viable but non-culturable state, thereby highlighting macrophage ontogeny as a critical determinant of infection outcome.
Drosophila tracheal terminal cells maintain their essential Foxo-dependent structural plasticity and respiratory function by being immune privileged through the absence of PGRP-LC, which prevents lethal immune activation and cell death that would otherwise compromise their dynamic remodeling capabilities.
The long isoform of ZAP restricts viral replication by preferentially binding viral RNA and recruiting a specific cascade of enzymes (KHNYN, TUT4/TUT7, DIS3L2, and XRN1) to execute complete transcript decay, a process enhanced by TRIM25 during viral infection.
This study demonstrates that specific HLA alleles imprint distinct, germline-encoded biases on TCR Vβ segment usage through direct molecular contacts, establishing a biological prior that shapes the T cell repertoire independently of thymic selection or specific infections.