212 papers
Immunology explores the intricate defense systems that keep our bodies safe from infections and disease. This field examines how our immune cells recognize threats, coordinate responses, and maintain a delicate balance between fighting invaders and avoiding self-harm. From understanding vaccine mechanisms to investigating autoimmune disorders, these studies reveal the dynamic biology protecting human health every day.
On Gist.Science, we ensure these critical discoveries remain accessible to everyone. We automatically process every new preprint in this category as it appears on bioRxiv, transforming complex research into both plain-language explanations and detailed technical summaries. This approach allows readers to grasp the core findings without getting lost in dense jargon, while still providing the depth needed for scientific inquiry.
Below are the latest immunology papers from bioRxiv, each accompanied by our curated summaries to help you navigate the newest breakthroughs in the field.
This study presents an optimized 27-color, three-laser spectral flow cytometry panel capable of simultaneously profiling 16 distinct immune and non-immune cell subsets across diverse mouse tissues, successfully demonstrating its utility in tracking dynamic cellular shifts and identifying novel cell populations in a poly(I:C) model.
This study identifies Kabuki syndrome as a novel Tregopathy caused by KMT2D loss-of-function, which disrupts the epigenetic signature at the FOXP3 distal enhancer to impair regulatory T cell development and offers in vitro demethylation as a potential therapeutic strategy.
Nasal administration of *Lacticaseibacillus rhamnosus* CRL1505 or its peptidoglycan postbiotic effectively restores nasopharynx-associated lymphoid tissue architecture and enhances mucosal innate immunity, thereby protecting protein-malnourished mice against *Streptococcus pneumoniae* infection.
This study utilizes transcriptomic timeseries analysis in a murine model of enteric infection to demonstrate that the liver coordinates and limits the duration of the systemic acute-phase response through an early, self-limited pulse of gene expression that resolves before the peak of disease.
This study identifies the basophil-specific GPCR Mrgpra6 as a critical regulator of type 2 immunity that mediates effective host defense against helminth infections by controlling early innate responses and shaping the basophil transcriptional landscape.
This study demonstrates that intranasal administration of anti-CD3 monoclonal antibodies attenuates post-COVID neuroinflammation and restores hippocampal neurogenesis and cognitive function in mice by reprogramming microglia and expanding regulatory T cells, suggesting a promising noninvasive therapeutic strategy for Long COVID-related cognitive impairment.
This study demonstrates that inflammatory cytokines associated with skin diseases and severe COVID-19 upregulate viral entry receptors (ACE2 and TMPRSS2) in human skin models, thereby significantly enhancing SARS-CoV-2 susceptibility and suggesting the skin is a previously underappreciated potential entry point for the virus.
This study utilizes a longitudinal, stability-aware framework to demonstrate that cladribine and ocrelizumab induce distinct, non-overlapping microRNA response signatures in multiple sclerosis patients, reflecting their divergent immunological mechanisms through coordinated upregulation of specific miRNAs associated with Th17/Treg balance and Wnt signaling for cladribine versus mTOR and NF-κB pathways for ocrelizumab.
This study establishes that the postnatal maturation of dendritic epidermal T cells and Langerhans cells in mice follows distinct, independent differentiation trajectories that are neither dependent on microbial colonization nor on the presence of canonical T cells.
This study demonstrates that chronic HIV persistence drives accelerated systemic immune aging in treated individuals, a process that is partially modulated by specific antiretroviral agents, particularly nucleoside reverse transcriptase inhibitors.