414 papers
Genomics is the study of an organism's complete set of DNA, offering a deep dive into the biological instructions that shape life. This field explores how genetic information influences traits, health, and evolution, moving beyond single genes to understand the complex interplay within entire genomes. From uncovering the roots of disease to mapping biodiversity, genomics provides the foundational data for many modern medical breakthroughs.
At Gist.Science, we process every new preprint in this category as it appears on bioRxiv, ensuring you stay ahead of the curve. Each paper is accompanied by both a clear, plain-language overview and a detailed technical summary, making cutting-edge research accessible to everyone regardless of their background. Below are the latest papers in genomics, freshly summarized and ready for you to explore.
This paper demonstrates that small reference sample sizes introduce systematic bias in population substructure estimates using Summix2, identifies a threshold of 150 individuals per group for accuracy, and proposes two effective bias correction methods tailored to different reference sample size scenarios.
This study reveals that in the Baltimore–Washington hybrid zone of the *Culex pipiens* mosquito complex, urbanization drives a genome-wide increase in human-commensal *molestus* ancestry, while temperature exerts opposing, locus-specific selective pressures that differentially favor or disfavor *quinquefasciatus* ancestry, collectively shaping the genetic landscape and potential arboviral risk of these vectors.
This study reveals that Sleeping Beauty transposition efficiency and local reintegration patterns in mouse embryonic stem cells are primarily governed by the chromatin accessibility and size of the launch site, the 3D genome folding architecture, and the specific sequence features of the transposon cargo, while the chromatin composition of the destination site has no significant effect.
This study establishes the first active surveillance framework for the wild bird virome in Switzerland, revealing a diverse viral landscape and the first detection of Bole tick virus 4 in local ticks carried by migratory birds, thereby highlighting the critical role of these "silent travelers" in introducing emerging zoonotic and tick-borne diseases.
By reanalyzing genomic data from 213 siphonophore specimens, researchers uncovered a diverse array of associated bacteria, prey, parasites, and endosymbionts, demonstrating that "molecular bycatch" from genome sequencing is a valuable method for revealing the ecological diversity of open-ocean organisms.
The paper introduces SHADES, a robust deep learning framework that leverages multi-scale haplotype signatures to accurately distinguish among various evolutionary processes, outperforming existing methods and successfully identifying both known and novel adaptive signals in European human genomes.
The paper introduces CNVSIM, an interpretable reference atlas that organizes genome-wide copy-number variation profiles into 112 reproducible cancer subtypes across 19 cancer roots, enabling accurate profile projection, diagnostic comparison, and cell line selection for cancer research.
By analyzing 6,907 Enterobacteriaceae genomes, this study reveals that while the genomic compartment (chromosome versus mobile genetic element) influences the specific rates of defense and anti-defense gene turnover, these genes exhibit evolutionarily coupled dynamics across bacterial lineages, with their gains and losses positively correlated regardless of whether they form antagonistic pairs.
This study reveals that in rice, rhythmic circadian gene transcription is driven by localized chromatin rewiring and dynamic fine-scale interactions within a largely stable global 3D genome architecture, where specific Myb-binding motifs facilitate temporal compartment transitions and gene coordination.
By integrating spatial genome-environment association models with a temporal analysis of adult, juvenile, and seedling cohorts across six European beech populations, this study reveals that while neutral demographic history often confounds climate signals, distinct population-specific selective pressures are driving directional allele-frequency shifts toward milder winter tolerance at the range edge and toward higher precipitation seasonality in Atlantic-influenced populations.