8 papers
This retrospective cohort study utilizing the UNOS database reveals that primary graft dysfunction in pediatric heart transplant recipients is significantly associated with worse post-transplant motor development, functional status, and a 3.5-fold higher stroke rate, independent of pre-transplant baseline, despite no significant differences in cognitive or academic outcomes.
This study demonstrates that in patients undergoing allogeneic hematopoietic stem cell transplantation, a metabolite-based biomarker (IMM-RI post-TX) reflecting the recovery of immunomodulatory microbial metabolites is a superior predictor of improved overall survival and reduced relapse-related mortality compared to traditional measures of bacterial diversity.
This economic evaluation of deceased donor organ transplantation in the UK concludes that while kidney transplants are cost-saving compared to dialysis, heart and liver transplants are cost-effective within standard thresholds, whereas lung transplants remain the least cost-effective option.
A retrospective cohort study of two donor hospitals that switched Organ Procurement Organization (OPO) affiliations found that the change led to statistically significant increases in organ donors and transplants driven by improved donor conversion, suggesting that realigning hospital-OPO relationships can enhance donation activity without negatively impacting the system.
This multicenter prospective study of 185 kidney transplant recipients found that [18F]FDG PET/CT imaging, measured by mean standardized uptake value ratios, fails to reliably detect or rule out subclinical acute rejection in stable patients at three months post-transplantation.
This study demonstrates that elevated pretransplant erythroferrone levels predict a composite outcome of 1-year all-cause mortality or moderate acute cellular rejection in heart transplant recipients, while disproportionately high posttransplant erythroferrone levels are specifically associated with acute cellular rejection.
This observational cohort study demonstrates that repeated histological diagnoses of kidney transplant injuries, such as T-cell mediated rejection, antibody-mediated rejection, microvascular inflammation, and BK polyomavirus nephropathy, are more common than single occurrences and significantly increase the risk of graft failure compared to initial diagnoses, highlighting an urgent need for improved treatment strategies for persistent or recurrent injury.
This national multicenter study demonstrates that integrating unsupervised clinical phenotyping with targeted genomic profiling significantly improves the prediction of recurrence risk and refines prognostic stratification for patients with resected perihilar cholangiocarcinoma beyond traditional anatomical staging.