155 papers
This study demonstrates that morning hyperglucagonemia disrupts insulin-induced hepatic metabolic memory in dogs, thereby significantly impairing subsequent afternoon net hepatic glucose uptake and glycogen synthesis by preventing the induction of key metabolic regulators like glucokinase.
NeuromechaniX is an automated platform that uses a large language model to extract structured data from approximately 2,000 motor-unit studies, revealing significant variations in discharge rates across muscles and sexes while highlighting critical gaps in research regarding females and older adults.
This study demonstrates that the combined effects of hypoxia and low temperature on *Drosophila melanogaster* physiology and reproduction are often non-additive and highly dependent on genetic background, revealing that single-stressor responses cannot predict organismal outcomes under multiple environmental challenges.
This study demonstrates that the airway mucin Muc5ac plays a dual role in parainfluenza virus infection by enhancing antiviral immunity while paradoxically mediating virus-induced airway hyperresponsiveness through parasympathetic nerve dysfunction.
This study reveals that post-inhibitory rebound (PIR) in pancreatic delta cells transforms somatostatin-mediated inhibition into synchronized excitation of alpha and beta cells, establishing a fundamental mechanism for islet plasticity and adaptive glucose regulation that is disrupted in type 2 diabetes.
This study demonstrates that Long COVID patients exhibit significantly elevated levels of platelet-monocyte aggregates with altered binding dynamics compared to healthy controls, identifying these aggregates as a sensitive biomarker for sustained thromboinflammatory activity in the condition.
This study reveals that high dietary salt intake triggers a novel endocrine cascade by elevating cortisol levels, which subsequently suppresses the bone-derived hormone FGF23 through glucocorticoid receptor activation, thereby linking salt consumption to potential risks for bone, kidney, and cardiovascular health.
This study demonstrates that five common anesthetic regimens in rats induce distinct patterns of cardiorespiratory depression, autonomic variability suppression, and cardiac biomarker alterations, highlighting the critical need to carefully select anesthetics to minimize physiological bias in preclinical research.
This study demonstrates that the common human GKRP P446L variant reduces glucokinase (GCK) activity, which in turn suppresses hepatic cholesterol synthesis and triglyceride accumulation, thereby explaining the variant's association with fatty liver disease and dyslipidemia.
This study reveals that chronic dietary ingestion of microplastics disrupts bone homeostasis by activating gut-derived serotonergic signaling through mechanosensory adaptations in enteroendocrine cells, leading to trabecular bone loss without inducing systemic inflammation or intestinal pathology.
This study identifies a novel muscarinic efferent pathway in mouse type II vestibular hair cells where acetylcholine suppresses BK potassium channels to enhance excitability during strong stimulation, complementing existing mechanisms to provide dynamic gain control in the vestibular periphery.
In a diet-induced obesity mouse model, the novel glucocorticoid receptor antagonist PT150, when combined with semaglutide, significantly reduced body weight and improved the maintenance of the new weight setpoint after treatment cessation, whereas PT150 alone had no significant effect.
Using a mouse model, this study demonstrates that acute mid-gestation heat exposure causing a ~1.2°C rise in core body temperature induces lasting adverse effects, including impaired placental function, fetal brain-sparing responses, and maternal cardiovascular damage characterized by fibrosis and elevated anti-angiogenic markers.
This study demonstrates that AAV-mediated leptin gene therapy significantly improves metabolic health in a mouse model of congenital generalised lipodystrophy, whereas adiponectin delivery yields no beneficial effects, highlighting leptin's potential as a long-term therapeutic alternative to daily injections.
This paper introduces the Heart Rate Persistence Index (HRPI), a novel, threshold-free metric that condenses sustained heart rate elevation into a single interpretable value by capturing both magnitude and duration, demonstrating robust stability and physiological relevance across diverse wearable datasets.
This study demonstrates that time-restricted feeding, particularly an 8-hour window, extends healthspan in both male and female C57BL/6J mice fed a regular diet, while significantly extending lifespan only in males.
This paper critiques the claims of Luo et al. regarding experiment-free exoskeleton assistance, arguing that their reported breakthrough is unverified due to physiological inconsistencies and a lack of code reproducibility, thereby concluding that the problem remains unsolved.
This study utilizes dynamic proteomic profiling to demonstrate that human skeletal muscle adapts to endurance and resistance training through distinct, protein-specific regulation of synthesis rates within shared subcellular locations, rather than solely through changes in bulk protein fractions.
In a mouse model of metabolic dysfunction-associated steatotic liver disease (MASLD), hepatocyte-specific deletion of HIF2α failed to protect against liver disease progression and instead exacerbated extra-hepatic complications, including myocardial lipid accumulation, cardiac dysfunction, and loss of lean body mass.
In the db/db mouse model of type 2 diabetes, the colonic mucus layer is significantly thinner and associated with goblet cell hyperplasia and increased bacterial colonization, while treatment with liraglutide failed to reverse these specific pathological changes.