137 papers
Physiology explores how living systems function, from the microscopic signals inside a single cell to the complex rhythms of an entire organism. This field seeks to understand the mechanical, physical, and biochemical processes that keep life moving, offering crucial insights into health, disease, and the body's remarkable ability to adapt.
On Gist.Science, we process every new preprint in this category from bioRxiv to make these rapid discoveries accessible to everyone. For each study, we provide both a clear, plain-language explanation and a detailed technical summary, ensuring that whether you are a curious student or a seasoned researcher, you can grasp the latest findings without getting lost in jargon.
The papers listed below represent the newest physiological research recently shared on bioRxiv, ready for you to explore.
This paper presents a rapid, reliable, and reproducible soil-based screening protocol for evaluating drought tolerance at the seedling stage across large collections of small grain cereals and their wild relatives, which effectively identifies contrasting genotypes that maintain their performance in later developmental stages.
This study demonstrates that the Cathepsin D-prolactin axis differentially regulates renal ischemia-reperfusion injury outcomes in a sex-specific manner, where Cathepsin D heterozygosity and prolactin levels modulate inflammatory and angiogenic responses to either protect against or exacerbate kidney damage.
Despite persistent motor impairments in the paretic hindlimbs of rats with chronic stroke, key structural muscle properties such as sarcomere length, dispersion, fascicle length, and serial sarcomere number remain preserved, suggesting that adult-onset neural injury alone does not necessarily induce substantial skeletal muscle structural adaptations.
This study demonstrates that active bed microclimate regulation using a smart bed significantly modulates sleep architecture, autonomic activity, and cortical function in adults, with heating accelerating sleep deepening and cooling reducing heart rate, thereby supporting the development of individualized temperature strategies for sleep optimization.
This study demonstrates that lysosomal calcium signaling, mediated by NAADP, regulates heart rhythm and atrial function by modulating pacemaker activity, influencing cAMP production, and interacting with neighboring organelles in a manner altered by atrial fibrillation.
This study employs bifurcation analysis and global sensitivity methods on a lipid-structured macrophage model to demonstrate that a transcritical bifurcation at infinity governs the transition from stable to unstable atherosclerotic plaques, revealing that macrophage proliferation, emigration, and efferocytosis are the dominant regulators of plaque dynamics near the critical threshold.
This paper proposes that Kleiber's law and other metabolic scaling phenomena arise from a general physical theory based on the Metabolic Holon, a locally optimized oxygen-supply unit that predicts absolute metabolic rates and lifespan across diverse organisms without empirical calibration.
This study demonstrates that while tamoxifen treatment causes transient disruption of estrous cyclicity in mice, it does not induce lasting transcriptional changes or alter long-term ovarian aging trajectories, thereby validating the use of tamoxifen-inducible Cre systems for reproductive aging research when appropriate controls are employed.
This study identifies a distinct plasma lncRNA expression profile in preeclampsia patients and elucidates a potential regulatory mechanism involving the dysregulated lncRNA-uc002ywy.3/miRNA-4498 axis and its impact on the PD-1/PD-L1 signaling pathway.
This study demonstrates that a second-generation "hypoxia in a pill" regimen, combining the hemoglobin affinity enhancer GBT601 with a HIF-2 inhibitor, effectively rescues neurodegenerative phenotypes and extends survival across multiple mouse models of mitochondrial deficiency, Friedreich's ataxia, and Parkinson's disease without inducing pulmonary hypertension.