155 papers
This study reveals that while Ventricular Assist Device support improves cardiac function in both children and adults with heart failure, pediatric hearts exhibit unique mitochondrial recovery characterized by the specific remodeling of tetralinoleoylcardiolipin, a mechanism not observed in adult hearts.
This study demonstrates that while inborn cardiorespiratory fitness influences body composition and the brown adipose tissue proteome, early-life exercise training universally enhances whole-body energy expenditure and brown adipose tissue thermogenic function and plasticity regardless of genetic fitness background.
While healthy individuals proactively adjust their gait mechanics and improve stability when warned of impending perturbations, people with chronic stroke fail to utilize such cues for proactive adjustments, relying instead on a consistent reactive strategy to maintain balance regardless of predictability.
This study identifies antigen-dependent activation of marginal zone B cells as a key driver of hypertension in both mice and humans, demonstrating that these cells amplify pathogenic immune responses through clonal expansion and enhanced interaction with CD8+ T cells, thereby establishing them as promising targets for precision immunomodulatory therapies.
This study reveals that pancreatic beta cells secrete GABA in pulses via the LRRC8A/D volume-regulated anion channel rather than through vesicular release, with this secretion being temporally coordinated with calcium oscillations to reinforce beta cell activity.
This study demonstrates that ovarian hormones are responsible for the reduced metabolic benefits of low-protein diets in female mice, as removing the ovaries sensitizes females to these benefits, making their response similar to that of males.
This study reveals that aging and type 2 diabetes drive a coordinated inflammatory phenotype in human pancreatic alpha cells characterized by IFN-γ signaling and CD8+ T cell recruitment, which can be reversed in mice by calorie restriction through the suppression of MHC-I expression and subsequent reduction in islet inflammation.
Lifelong dietary valine restriction improves healthspan in both male and female mice and extends lifespan specifically in males, likely through sex-specific mechanisms involving enhanced mitochondrial respiration and reduced senescent cell burden.
This study demonstrates that while incorporating muscle mass into Hill-type models significantly improves force predictions for larger-than-human muscles or high-cadence movements, the difference between mass-enhanced and traditional massless models remains negligible (<1%) for standard human-sized locomotion.
This study demonstrates that focusing on stable, pleiotropic QTLs controlling adaxial stomatal anatomy, which exhibits higher heritability and stress-specific plasticity compared to conductance, offers a promising strategy for enhancing wheat photosynthetic efficiency and climate resilience under drought and heat stress.
This study demonstrates that magnetic resonance spectroscopy (MRS) can noninvasively map intramuscular temperature changes in the thigh during cold water immersion and subsequent exercise, revealing significant depth-dependent cooling and rewarming patterns that offer new insights for optimizing heat illness treatment.
This study validates a novel, catheter-free, non-radiolabeled mass spectrometry method using 2-fluoro-2-deoxyglucose to quantify insulin-stimulated, tissue-specific glucose clearance in conscious mice, offering a high-throughput alternative for pre-clinical research that integrates with multi-omics technologies.
This study demonstrates that the senescence-inhibitory p53 isoform Δ133p53 extends lifespan and counteracts aging in progeria and naturally aged mice by repressing the proinflammatory chemokine CXCL10, a finding supported by inverse associations observed in human tissue datasets.
This study demonstrates that empagliflozin confers renoprotection in heart failure by suppressing renal sympathetic hyperactivity and disrupting a maladaptive neuro-epithelial-immune axis, which shifts renal macrophages toward a reparative phenotype and reduces tubular inflammation independently of the renin-angiotensin system.
This study identifies a conserved mechanism called granulosa cell energy storage (GCES), wherein granulosa cells accumulate glycogen via the hCG-MAPK-RUNX1-Insulin signaling axis to fuel the avascular corpus luteum during early luteogenesis, a process that can be clinically enhanced by glucose intake to improve reproductive outcomes.
This prospective study of trauma patients reveals that while hemorrhagic shock triggers an initial surge in circulating stem and progenitor cells and cytokines, their subsequent sharp decline and persistent early elevation in non-survivors correlate with worse outcomes, suggesting that serial profiling of these biomarkers could serve as a prognostic tool and identify a therapeutic window for regenerative interventions.
This study demonstrates that maternal hypertension and the use of various cardiovascular medications during pregnancy can dysregulate human fetoplacental vascular tone, potentially impairing placental perfusion and highlighting the need for further research to guide safe prescribing practices.
Although skeletal muscle Adrβ2 is essential for exercise-induced Pgc-1α upregulation and enhances endurance capacity, it is not required for the metabolic benefits of exercise in preventing diet-induced obesity.
This study identifies myeloid Gi signaling as a weight-independent immunometabolic switch that controls systemic insulin sensitivity by regulating a cytokine balance between IL-6-mediated insulin sensitization and IL-1β-mediated insulin resistance, thereby offering a novel therapeutic target for metabolic disease.
This study demonstrates that tandem cycling performance relies on rider position and individual physiological capacity rather than the degree of matching between partners, with stokers consistently producing less power than pilots or their solo efforts while the combined output remains largely unaffected by partner disparity.