155 papers
This study demonstrates that while cAMP alone activates the core decidualization program in 3D human endometrial organoids, supplementing with ovarian steroid hormones (estradiol and progesterone) elicits a broader, more physiologically relevant response characterized by enhanced structural remodeling and diverse transcriptional changes.
This paper challenges the assumption that clinical deep sleep metrics reliably predict neurobehavioral recovery by demonstrating that continuous slow-wave activity (SWA) exhibits a context-dependent "dual indeterminacy," where SWA levels during baseline sleep and subsequent wakefulness show opposing associations with fatigue, thereby explaining the failure of traditional staging and proposing a new framework based on continuous electrophysiology.
This study reveals that canonical Wnt/β-catenin signaling acts as a developmental brake on beige adipocyte formation, and its suppression during the peri-weaning period activates a Wnt5a-Ca2+-AMPK axis to drive SNS-independent thermogenesis and sustain long-term energy expenditure.
This study demonstrates that while hepatocyte PPARγ is dispensable for fasting- and refeeding-induced regulation of methionine metabolism, its upregulation during diet-induced obesity acts as a negative regulator of key methionine metabolism genes (such as *Bhmt* and *Cbs*), thereby contributing to the development of metabolic dysfunction-associated steatohepatitis (MASH).
This study identifies a novel, insulin-independent glucose uptake pathway in skeletal muscle called mSGLT, which is coupled to Na,K-ATPase activity and functions alongside GLUT4 to offer a potential therapeutic target for treating hyperglycemia when insulin sensitivity is impaired.
This study identifies distinct subpopulations of LeprGlp1r neurons in the arcuate and dorsomedial hypothalamic nuclei that independently regulate food intake and blood pressure, respectively, revealing a molecular basis for dissociating metabolic and cardiovascular control.
Maternal adherence to a Mediterranean diet during pregnancy modifies placental lipid composition and downregulates key pathways involved in lipid metabolism, nutrient transport, inflammation, and tissue remodeling, thereby elucidating the mechanisms linking maternal diet to placental metabolic function.
This study reveals that in *Drosophila melanogaster*, the ovary regulates protein-specific appetite by suppressing the relaxin-like hormone Dilp8 when oogenesis is disrupted, thereby establishing a signaling axis that aligns nutrient intake with reproductive demands.
By combining advanced imaging and biosensors, this study reveals how the mouse vas deferens coordinates muscular contraction with distinct kinase signaling pathways (ROCK/PKA for global contraction and ERK for distal remodeling) to transform a collapsed, wrinkled duct into an open channel for directional sperm transport during ejaculation.
This study reveals that a high-fat diet increases endometrial hyperplasia risk by reprogramming estrogen-driven stromal fibroblasts into a pro-fibrotic state, which disrupts normal tissue regeneration, impairs immune clearance, and promotes disease severity.
This study demonstrates that the sarcomere-associated C-terminus of polycystin-1 in cardiomyocytes activates a Gi/o-independent PI3K-Akt-mTOR-S6K1-S6 signaling axis to drive ribosome biogenesis and protein synthesis, thereby promoting cardiomyocyte growth without inducing a canonical hypertrophic gene program.
This study on Manduca sexta larvae demonstrates that while dietary iron supplementation significantly increases hemolymph iron levels, it does not necessarily exacerbate bacterial infections, as the effect on survival varies depending on the pathogen type and the presence of antibiotics, thereby challenging the hypothesis that extra iron universally worsens infection severity.
This study demonstrates that the GPR39 receptor and its endogenous agonist 15-hydroxyeicosatetraenoic acid (15-HETE) jointly orchestrate coronary autoregulation by maintaining constant blood flow across varying pressures, a mechanism confirmed by the abolition of autoregulation upon GPR39 antagonism in a canine model.
This study demonstrates that mental fatigue impairs cycling endurance performance by increasing the perception of effort, rather than by altering muscle activation or motor command.
This study demonstrates that blind adults living near the equator exhibit significantly higher rates of circadian entrainment than previously observed in temperate regions, proving that exceptionally regular environmental cues can sustain robust biological rhythms in the absence of light.
This study identifies an adipose-driven complement-lipid axis, mediated by complement factor D, that regulates nociceptive vulnerability and exacerbates obesity-associated osteoarthritis pain independent of joint damage, revealing new extra-articular targets for non-opioid therapies.
This study demonstrates that strain-specific differences in renal sodium handling between C57Bl/6 and 129S2/SV mice are driven by distinct expression patterns of key transporters like NHE3, NKCC2, and NCC, which vary by sex and result in altered plasma electrolyte levels and diuretic responses.
This study demonstrates that the extracellular matrix retains a "memory" of metabolic dysfunction-associated steatohepatitis (MASH) that persists after decellularization, actively promoting steatosis, fibrosis, and metabolic dysfunction in both in vitro and in vivo settings, thereby confirming that diseased ECM can drive disease progression even when repopulated with healthy cells.
This study demonstrates that endothelial-derived Wnt9b and Wnt5a act as autocrine/paracrine vasodilators by activating PKD1/PKD2 channels (and Fzd-7 for Wnt5a) to trigger eNOS-mediated signaling, a process initiated by intravascular flow via AT1 receptors that ultimately reduces blood pressure.
Although renal NLRP3 levels increase in both male and female DOCA-salt hypertensive rats, inhibiting NLRP3 with MCC950 attenuates blood pressure elevations and reduces T cell infiltration only in males, highlighting a sex-specific mechanism in DOCA-salt hypertension.