137 papers
Physiology explores how living systems function, from the microscopic signals inside a single cell to the complex rhythms of an entire organism. This field seeks to understand the mechanical, physical, and biochemical processes that keep life moving, offering crucial insights into health, disease, and the body's remarkable ability to adapt.
On Gist.Science, we process every new preprint in this category from bioRxiv to make these rapid discoveries accessible to everyone. For each study, we provide both a clear, plain-language explanation and a detailed technical summary, ensuring that whether you are a curious student or a seasoned researcher, you can grasp the latest findings without getting lost in jargon.
The papers listed below represent the newest physiological research recently shared on bioRxiv, ready for you to explore.
This study demonstrates that cardiac microtubules are essential active regulators of transverse (t)-tubule architecture, where CLIP-170-mediated capture and dynein-dependent elongation drive t-tubule formation while ongoing microtubule dynamics are required to maintain their mature structure.
A study in neonatal piglets demonstrated that a novel infant formula containing recombinant human milk proteins (H1) was noninferior to donor human milk and standard formula regarding growth, intestinal histology, and plasma amino acid levels, despite some differences in organ size and local cytokine activity.
This study demonstrates that in Duchenne muscular dystrophy, collagen abundance alone does not define pathological fibrosis, as distinct extracellular matrix states characterized by specific organization, biological activity, and YAP-mediated mechanosignaling can uncouple collagen accumulation from disease severity.
This study demonstrates that natural variations in menstrual cycle phase lengths, rather than total cycle duration, are systematically associated with daily symptom burden across multiple domains, highlighting the inadequacy of fixed 28-day cycle assumptions and the necessity for person-specific, ovulation-timed monitoring in research and clinical practice.
This study identifies a novel TRPA1 gain-of-function variant (p.M978V) associated with painful sensory neuropathy that enhances channel activity and trafficking through a PIP2-dependent gating mechanism.
This study identifies a Gαq/11-IP3R1-ANO1 signaling axis as the critical mechanism driving pressure-induced lymphatic chronotropy, while ruling out the involvement of various mechanosensitive TRP channels and demonstrating that although Gαq/11-coupled GPCRs are essential, the specific receptor mediating this mechanotransduction remains to be identified.
This study identifies renal disease and anemia as primary predictors of mortality in aging marmosets and validates a 10-variable composite risk scale that accurately forecasts three-year survival, offering a practical screening tool for managing captive populations.
This study demonstrates that while chest-mounted light dosimeters can provide sufficiently accurate aggregated timing and duration metrics for scalable studies, both chest and wrist placements significantly underestimate eye-level light exposure—particularly at night and for temporal dynamics—with wrist placement introducing the greatest and most unpredictable bias, thereby necessitating near-eye measurement for precise, small-sample, or time-resolved analyses.
This longitudinal study demonstrates that flatter increases in vagally mediated heart rate variability and weaker heart rate decreases during infancy predict higher psychosocial difficulties at age 14 specifically in males, highlighting early autonomic nervous system maturation as a sex-specific predictor of adolescent outcomes.
This study demonstrates that FoxO transcription factors are evolutionarily conserved regulators that maintain airway epithelial homeostasis by coordinating adaptive stress responses, with their reduced expression and altered function linked to increased stress sensitivity in asthma models across flies, mice, and humans.