76 papers
Physiology explores how living systems function, from the microscopic signals inside a single cell to the complex rhythms of an entire organism. This field seeks to understand the mechanical, physical, and biochemical processes that keep life moving, offering crucial insights into health, disease, and the body's remarkable ability to adapt.
On Gist.Science, we process every new preprint in this category from bioRxiv to make these rapid discoveries accessible to everyone. For each study, we provide both a clear, plain-language explanation and a detailed technical summary, ensuring that whether you are a curious student or a seasoned researcher, you can grasp the latest findings without getting lost in jargon.
The papers listed below represent the newest physiological research recently shared on bioRxiv, ready for you to explore.
By combining 3D multiscale and cryogenic imaging, this study reveals that accelerating bone growth in embryonic quail is achieved not by increasing the transport speed of individual cells, but by expanding the number of mineralizing cells, thereby maintaining a consistent and perfectly tuned calcium delivery capacity per cell throughout development.
By integrating comparative genomics, AlphaFold3-based structural modeling, and functional validation, this study reveals that the N-terminal domain of the CatSper1 subunit acts as an evolutionary hotspot where histidine-rich clusters sense temperature and pH changes to modulate supramolecular assembly and coordinate sperm calcium channel activation.
This study utilized Structural Equation Modeling to demonstrate that muscle stiffness and relaxation time are significant predictors of explosive neuromuscular performance in elite male weightlifters, while other passive mechanical properties like tone and elasticity showed weak or no relationships.
This study reveals that high dietary salt intake triggers a novel endocrine cascade by elevating cortisol levels, which subsequently suppresses the bone-derived hormone FGF23 through glucocorticoid receptor activation, thereby linking salt consumption to potential risks for bone, kidney, and cardiovascular health.
This study demonstrates that the common human GKRP P446L variant reduces glucokinase (GCK) activity, which in turn suppresses hepatic cholesterol synthesis and triglyceride accumulation, thereby explaining the variant's association with fatty liver disease and dyslipidemia.
This study reveals that chronic dietary ingestion of microplastics disrupts bone homeostasis by activating gut-derived serotonergic signaling through mechanosensory adaptations in enteroendocrine cells, leading to trabecular bone loss without inducing systemic inflammation or intestinal pathology.
This study demonstrates that AAV-mediated leptin gene therapy significantly improves metabolic health in a mouse model of congenital generalised lipodystrophy, whereas adiponectin delivery yields no beneficial effects, highlighting leptin's potential as a long-term therapeutic alternative to daily injections.
This study demonstrates that time-restricted feeding, particularly an 8-hour window, extends healthspan in both male and female C57BL/6J mice fed a regular diet, while significantly extending lifespan only in males.
This study utilizes dynamic proteomic profiling to demonstrate that human skeletal muscle adapts to endurance and resistance training through distinct, protein-specific regulation of synthesis rates within shared subcellular locations, rather than solely through changes in bulk protein fractions.
In a mouse model of metabolic dysfunction-associated steatotic liver disease (MASLD), hepatocyte-specific deletion of HIF2α failed to protect against liver disease progression and instead exacerbated extra-hepatic complications, including myocardial lipid accumulation, cardiac dysfunction, and loss of lean body mass.