155 papers
This study identifies Sertad4 as a fibroblast-enriched regulator of pathological cardiac remodeling that is upregulated in heart failure and myocardial infarction, demonstrating that its genetic deletion attenuates fibrosis, hypertrophy, and ventricular dysfunction, thereby suggesting it as a promising cell-type-selective therapeutic target to avoid the systemic toxicity associated with direct BRD4 inhibition.
This study demonstrates that above-chance decoding of emotion from single-trial EEG during imagined vocalisation is largely driven by involuntary facial muscle activity, particularly for happiness, rather than purely neural speech signals.
This study demonstrates that chronic treatment with the α1A-adrenergic agonist A61603 reverses right ventricular failure in a mouse model by restoring mitochondrial function, specifically improving oxygen consumption and ATP levels.
This study demonstrates that phase-dependent gait stability measures, despite varying similarly to gait robustness throughout the cycle, fail to reliably predict the latter in a compass walker model, suggesting they are inadequate for assessing fall risk in humans.
Although a capture-handling-restraint protocol induces short-term physiological stress and delays in provisioning behavior in wild great tits, these immediate responses do not significantly impact their longer-term reproductive success, despite the study's limitation of lacking an uncaptured control group.
The paper introduces the HEAD model, a comprehensive lumped-parameter framework that integrates cerebrovascular, ocular, and cerebrospinal fluid dynamics to simulate gravitational and postural effects on intracranial and intraocular pressures, thereby elucidating the mechanisms behind Spaceflight-Associated Neuro-ocular Syndrome (SANS) and providing validated boundary conditions for further structural analysis.
This study demonstrates that extreme multi-stage ultra-endurance exercise induces arterial stiffening through a ROS-dependent mechanism driven by a systemic shift involving altered arginine metabolism, ceramide accumulation, and innate immune activation, rather than a reduction in endothelial nitric oxide production.
This study proposes a theoretical framework demonstrating that sarcomere length dynamics during the isovolumic phases, regulated by the balance between ventricular volume and contraction force rather than volume alone, mechanically modulate contractile force to shorten isovolumic relaxation time and enhance hemodynamic efficiency.
This study demonstrates that in healthy adults, increasing the attentional demand of spatial navigation by removing sensory cues impairs navigation performance but does not negatively affect gait and balance metrics, suggesting that locomotor control is robust to navigation-related cognitive loads.
Chronic cold exposure enables UCP1-deficient mice to achieve effective thermogenesis through mitochondrial plasticity characterized by enhanced MCU-dependent calcium uptake, increased ER-mitochondria tethering, and respiratory complex reorganization.
This study establishes a cell-type-resolved transcriptomic atlas of skeletal muscle in women with PCOS, revealing that hyperinsulinemia and hyperandrogenism drive pro-fibrotic remodeling through fibro-adipogenic progenitor reprogramming and altered myofiber crosstalk, which can be partially reversed by metformin.
This study demonstrates that the PNPLA3I148M variant acts as an intrinsic regulator of bone mass by promoting bone loss and marrow adiposity through transcriptomic reprogramming, independent of its association with metabolic-dysfunction associated steatotic liver disease (MASLD).
This study demonstrates that a specific high-fat, high-cholesterol, and fructose-supplemented diet successfully induces obesity and MASLD in both male and female mice, but progression to MASH with fibrosis occurs exclusively in males through a hepatocyte PPARγ-dependent mechanism involving the downregulation of methionine metabolism.
Researchers developed a novel non-invasive immunochromatographic assay using species-specific monoclonal antibodies to accurately detect ovulation and early pregnancy in common marmosets and potentially other New World primates, thereby eliminating the need for invasive blood sampling and supporting the 3Rs principles in reproductive research.
This study demonstrates that following active muscle stretch or shortening, neural drive to the human tibialis anterior is respectively decreased or increased through adjustments in motor unit recruitment and discharge rates to account for residual force enhancement and depression, with discharge rate modulation being specific to contraction intensity.
This study demonstrates that a tactile startle stimulus elicits a reproducible, temporally structured, and multimodal sympathetic nervous system signature across multiple physiological effector systems in healthy participants, independent of biological sex or cardiac gating, suggesting its potential utility as a diagnostic tool for assessing autonomic dysfunction.
This study utilizes multi-omic profiling to demonstrate that small and large plasma extracellular vesicles in early pregnancy possess distinct yet complementary molecular signatures reflecting placental, metabolic, and structural adaptations, thereby establishing a foundational framework for linking these vesicle subtypes to pregnancy outcomes.
This study demonstrates that Angiotensin II exacerbates vascular injury by amplifying CCL5/CCR5 signaling, which drives mitochondrial dysfunction and oxidative stress in vascular smooth muscle cells, thereby promoting vascular inflammation and impairment.
In a randomized crossover study of young adult females, continuous hypoxemia was found to significantly increase late postprandial plasma beta-hydroxybutyrate concentrations compared to both normoxemia and intermittent hypoxemia following a high-fat meal.
This paper argues that *eat-2* mutants in *C. elegans* are an unreliable model for dietary restriction studies because their extended lifespan is primarily caused by reduced susceptibility to bacterial infection rather than a genuine dietary restriction effect.