155 papers
This study demonstrates that in overwintering *Bombus impatiens* queens, the impact of thermal variability on metabolic rate and survival is not uniform but depends critically on the mean temperature, with fluctuations around a lower mean (2°C) accelerating energy loss while those around a higher mean (4°C) buffer it through physiological compensation.
This study demonstrates that TUDCA treatment restores vascular and perivascular adipose tissue function in male mice subjected to post-weaning protein restriction by attenuating endoplasmic reticulum stress, fibrosis, and associated molecular dysregulation.
This study demonstrates that chronically elevated FGF23 levels drive sustained renal ERK signaling and inflammatory responses in chronic kidney disease, which can be effectively mitigated by C-terminal FGF23 (cFGF23) gene therapy.
This study demonstrates that the dynamin inhibitor dynasore exerts a hormetic effect on longitudinal bone growth in ex vivo mouse metatarsal cultures, where low doses stimulate elongation by enhancing matrix accumulation and mTORC1 signaling while blocking autophagy, whereas high doses impair growth by abolishing chondrocyte proliferation.
This study demonstrates that iota-carrageenan effectively protects human corneal cells and porcine ocular tissue from desiccation-induced damage in vitro and ex vivo, supporting its potential as a superior ingredient for lubricant eye drops in managing dry eye disease.
In obese ZSF-1 rats with type 2 diabetes, empagliflozin exerts nephroprotective effects by reducing tubular injury and preserving mitochondrial function through enhanced respiratory capacity, restored OXPHOS complex expression, and improved mitochondrial quality control, despite not improving glomerular filtration rate.
This study reveals that endothelial Kir2.1 channels act as a critical mechanistic linker connecting the glycocalyx, Piezo1-mediated calcium influx, and the PI3K/Akt1 signaling pathway to regulate flow-induced vasodilation, with their functional loss contributing to vascular impairment in hypertension and aging.
This study demonstrates that correcting for allometric dosing bias by matching body weight rather than age reveals that male rats exhibit greater susceptibility to bleomycin-induced acute lung injury than females, driven by distinct sex-specific molecular signatures involving miR-672-3p suppression, heightened inflammation, and divergent pathway activation.
This study overturns the long-held belief that bats do not move their eyes by providing the first empirical evidence that Seba's short-tailed bats possess robust visual and otolith-driven gaze stabilization mechanisms, while exhibiting a weak semicircular canal-driven vestibulo-ocular reflex that is likely modulated by behavioral state rather than anatomical constraints.
Sodium tungstate enhances vascularization and survival of transplanted insulin-producing cells in diabetic models by inhibiting phosphatase activity to upregulate VEGFA and activate MAPK/ERK signaling, thereby improving graft integration and therapeutic efficacy without requiring exogenous endothelial supplementation.
This study utilizes multi-omics profiling of a pig model to characterize the cellular and molecular landscape of progressive right ventricular dysfunction, identifying specific mechanisms such as impaired mitochondrial proteostasis, defective macrophage efferocytosis, and activated ribotoxic stress responses as potential therapeutic targets.
This study demonstrates that sleeve gastrectomy performed on young, lean mice provides durable, weight-loss-independent protection against midlife obesity and metabolic deterioration, likely mediated by surgery-specific gut microbiome remodeling.
This study identifies chitinase 3-like 1 (Chi3l1) as a critical metabolic regulator that selectively protects embryo-derived Kupffer cells from stress-induced death by inhibiting glucose uptake, thereby preventing their replacement by inflammatory monocyte-derived macrophages and mitigating the progression of metabolic dysfunction-associated steatotic liver disease (MASLD).
This study demonstrates that the genetic background of male mice critically modulates the penetrance of MAFA-S64F-mediated diabetes, where a C57BL/6J background protects against dysglycemia by preserving MafA function and downregulating senescence and retinoic acid signaling pathways, whereas a mixed background leads to overt diabetes and accelerated beta-cell aging.
This study demonstrates that dietary glutamine restriction reduces atherosclerotic plaque rupture and mortality in mice by promoting a beneficial fibrotic phenotype in smooth muscle cells, thereby identifying glutamine depletion as a novel strategy to enhance plaque stability.
Aerobic swimming exercise alleviates hypertension and cardiac dysfunction in spontaneously hypertensive rats by inhibiting myocardial glycation and suppressing the AGEs/RAGE-p38 MAPK-NF-κB signaling pathway.
This study demonstrates that the melanocortin receptor 4 agonist setmelanotide effectively reverses opioid-induced respiratory depression in mice by increasing respiratory rate and reducing apnea without compromising opioid analgesia.
This study identifies pulmonary microvascular rarefaction driven by excessive endothelial autophagy as a novel mechanism that impairs gas exchange, causes dyspnea and exercise intolerance, and accelerates the progression of heart failure with preserved ejection fraction (HFpEF), suggesting that targeting this pathway or providing moderate oxygen therapy could mitigate cardiopulmonary morbidity.
This study identifies a loss-of-function variant in the GFRAL receptor that is associated with increased alcohol consumption in humans and demonstrates that GDF15 acts as an endocrine signal induced by alcohol exposure to suppress intake, suggesting a natural mechanism for limiting alcohol consumption.
Five days of isothermic heat acclimation enhances cardiovascular and thermoregulatory performance in endurance athletes by lowering resting heart rate, expanding plasma volume, and increasing sweat loss, yet it fails to mitigate renal tubular stress, fluid-regulatory strain, or sympathetic activity during subsequent exercise in hot, humid conditions.