109 papers
Physiology explores how living systems function, from the microscopic signals inside a single cell to the complex rhythms of an entire organism. This field seeks to understand the mechanical, physical, and biochemical processes that keep life moving, offering crucial insights into health, disease, and the body's remarkable ability to adapt.
On Gist.Science, we process every new preprint in this category from bioRxiv to make these rapid discoveries accessible to everyone. For each study, we provide both a clear, plain-language explanation and a detailed technical summary, ensuring that whether you are a curious student or a seasoned researcher, you can grasp the latest findings without getting lost in jargon.
The papers listed below represent the newest physiological research recently shared on bioRxiv, ready for you to explore.
This study demonstrates that while both C26 and CT26 colorectal cancer cell lines induce skeletal muscle atrophy, the C26 model uniquely drives severe systemic cachexia characterized by body weight loss, impaired muscle function, and heightened inflammation, whereas CT26 exhibits a milder phenotype with less impact on overall physical function.
This study demonstrates that normobaric hypoxia significantly alters the transcriptional response of human skeletal muscle to high-intensity interval exercise, specifically inducing a unique gene expression profile at 24 hours post-exercise characterized by mitochondrial downregulation and HIF-1 mediated regulation.
This study demonstrates that a wearable smartwatch prototype integrating Impedance Plethysmography (IPG) and Photoplethysmography (PPG) offers superior sensitivity to deep systemic hemodynamics and arterial modulation compared to PPG alone, as evidenced by pilot data showing IPG's temporal lead and distinct signal evolution during rest and vascular challenges.
This paper presents a simplified, syringe pump-driven Langendorff method for isolating high-viability adult mouse ventricular myocytes, which utilizes constant-flow perfusion and an inline heater to enhance reproducibility and accessibility for laboratories lacking dedicated perfusion infrastructure.
By combining 3D multiscale and cryogenic imaging, this study reveals that accelerating bone growth in embryonic quail is achieved not by increasing the transport speed of individual cells, but by expanding the number of mineralizing cells, thereby maintaining a consistent and perfectly tuned calcium delivery capacity per cell throughout development.
By integrating comparative genomics, AlphaFold3-based structural modeling, and functional validation, this study reveals that the N-terminal domain of the CatSper1 subunit acts as an evolutionary hotspot where histidine-rich clusters sense temperature and pH changes to modulate supramolecular assembly and coordinate sperm calcium channel activation.
This study utilized Structural Equation Modeling to demonstrate that muscle stiffness and relaxation time are significant predictors of explosive neuromuscular performance in elite male weightlifters, while other passive mechanical properties like tone and elasticity showed weak or no relationships.
This study reveals that high dietary salt intake triggers a novel endocrine cascade by elevating cortisol levels, which subsequently suppresses the bone-derived hormone FGF23 through glucocorticoid receptor activation, thereby linking salt consumption to potential risks for bone, kidney, and cardiovascular health.
This study demonstrates that the common human GKRP P446L variant reduces glucokinase (GCK) activity, which in turn suppresses hepatic cholesterol synthesis and triglyceride accumulation, thereby explaining the variant's association with fatty liver disease and dyslipidemia.
This study reveals that chronic dietary ingestion of microplastics disrupts bone homeostasis by activating gut-derived serotonergic signaling through mechanosensory adaptations in enteroendocrine cells, leading to trabecular bone loss without inducing systemic inflammation or intestinal pathology.