76 papers
Physiology explores how living systems function, from the microscopic signals inside a single cell to the complex rhythms of an entire organism. This field seeks to understand the mechanical, physical, and biochemical processes that keep life moving, offering crucial insights into health, disease, and the body's remarkable ability to adapt.
On Gist.Science, we process every new preprint in this category from bioRxiv to make these rapid discoveries accessible to everyone. For each study, we provide both a clear, plain-language explanation and a detailed technical summary, ensuring that whether you are a curious student or a seasoned researcher, you can grasp the latest findings without getting lost in jargon.
The papers listed below represent the newest physiological research recently shared on bioRxiv, ready for you to explore.
This study demonstrates that a specific high-fat, high-cholesterol, and fructose-supplemented diet successfully induces obesity and MASLD in both male and female mice, but progression to MASH with fibrosis occurs exclusively in males through a hepatocyte PPARγ-dependent mechanism involving the downregulation of methionine metabolism.
This study utilizes multi-omic profiling to demonstrate that small and large plasma extracellular vesicles in early pregnancy possess distinct yet complementary molecular signatures reflecting placental, metabolic, and structural adaptations, thereby establishing a foundational framework for linking these vesicle subtypes to pregnancy outcomes.
This study demonstrates that Angiotensin II exacerbates vascular injury by amplifying CCL5/CCR5 signaling, which drives mitochondrial dysfunction and oxidative stress in vascular smooth muscle cells, thereby promoting vascular inflammation and impairment.
This paper argues that *eat-2* mutants in *C. elegans* are an unreliable model for dietary restriction studies because their extended lifespan is primarily caused by reduced susceptibility to bacterial infection rather than a genuine dietary restriction effect.
This study demonstrates that TUDCA treatment restores vascular and perivascular adipose tissue function in male mice subjected to post-weaning protein restriction by attenuating endoplasmic reticulum stress, fibrosis, and associated molecular dysregulation.
This study demonstrates that chronically elevated FGF23 levels drive sustained renal ERK signaling and inflammatory responses in chronic kidney disease, which can be effectively mitigated by C-terminal FGF23 (cFGF23) gene therapy.
This study utilizes multi-omics profiling of a pig model to characterize the cellular and molecular landscape of progressive right ventricular dysfunction, identifying specific mechanisms such as impaired mitochondrial proteostasis, defective macrophage efferocytosis, and activated ribotoxic stress responses as potential therapeutic targets.
This study identifies chitinase 3-like 1 (Chi3l1) as a critical metabolic regulator that selectively protects embryo-derived Kupffer cells from stress-induced death by inhibiting glucose uptake, thereby preventing their replacement by inflammatory monocyte-derived macrophages and mitigating the progression of metabolic dysfunction-associated steatotic liver disease (MASLD).
Aerobic swimming exercise alleviates hypertension and cardiac dysfunction in spontaneously hypertensive rats by inhibiting myocardial glycation and suppressing the AGEs/RAGE-p38 MAPK-NF-κB signaling pathway.
This study identifies a loss-of-function variant in the GFRAL receptor that is associated with increased alcohol consumption in humans and demonstrates that GDF15 acts as an endocrine signal induced by alcohol exposure to suppress intake, suggesting a natural mechanism for limiting alcohol consumption.