physiology papers | Gist.Science

Five days of heat acclimation improves cardiovascular and thermoregulatory responses without altering renal stress biomarkers in endurance athletes

Five days of isothermic heat acclimation enhances cardiovascular and thermoregulatory performance in endurance athletes by lowering resting heart rate, expanding plasma volume, and increasing sweat loss, yet it fails to mitigate renal tubular stress, fluid-regulatory strain, or sympathetic activity during subsequent exercise in hot, humid conditions.

Snape, D., Wainwright, B., Parsons, I. T. + 3 more2026-03-09❤️ physiology

Microtubule detyrosination alters nuclear mechanotransduction and leads to pro-hypertrophic signaling in hypertrophic cardiomyopathy

This study demonstrates that in hypertrophic cardiomyopathy, microtubule detyrosination drives nuclear morphological abnormalities and impaired mechanotransduction, leading to pathological YAP1 signaling and hypertrophy, which can be reversed by inhibiting detyrosination.

Duursma, I., Micali, L. R., Nollet, E. E. + 11 more2026-03-08❤️ physiology

Impaired renal base excretion in secretin receptor knock-out mice during prolonged base-loading

This study demonstrates that secretin receptor knockout mice exhibit impaired renal base excretion and exacerbated systemic base accumulation during prolonged base-loading due to diminished pendrin function, confirming the critical role of the secretin-SCTR axis in regulating both acute and chronic base excess.

Jensen, T., Andersen, J. F., Trans, L. W. + 8 more2026-03-08❤️ physiology

Seasonal Dynamics of Nonstructural Carbon Compounds in Pine Forest

This study reveals that in temperate pine forests, seasonal carbon balance is primarily driven by the rapid redistribution of soluble sugars rather than significant fluctuations in overall non-structural carbon storage, as evidenced by year-round measurements showing sugars account for the majority of annual flux while starch and lipids play more stable or secondary roles.

Sarpong, C. K., Nkrumah, M. K., Baniya, B. + 2 more2026-03-08❤️ physiology

A Broad-Spectrum Chemokine Inhibitor Prevents Preterm Labor in Mice by Supressing Inflammation Induced by Intra-Amniotic Injection of Interleukin-1 alpha

This study demonstrates that the Broad-Spectrum Chemokine Inhibitor (BSCI) effectively prevents interleukin-1 alpha-induced preterm labor in mice by suppressing uterine inflammation, reducing leukocyte infiltration, and maintaining uterine quiescence through the inhibition of labor-associated gene expression and chromatin remodeling.

Boros-Rausch, A., Ballan, N., Celik, I. + 7 more2026-03-07❤️ physiology

Loss of Bone Marrow β1/β2-Adrenergic Receptors Reprograms Host-Microbiota Interactions and Protects Against Diet-Induced Obesity

Loss of bone marrow β1/β2-adrenergic receptors protects mice against diet-induced obesity by reprogramming the gut microbiota to enrich Bacteroidetes, which reduces dietary lipid absorption and alters fecal lipid profiles.

Alviter Plata, A., Ahmari, N., Gadient, J. + 3 more2026-03-07❤️ physiology

Epigenetic Silencing of Carotid Body TRPM7 Attenuates Hypertension in Obese Mice

This study demonstrates that administering methylated DNA oligonucleotides to reverse leptin-induced epigenetic silencing of TRPM7 in the carotid bodies of obese mice attenuates hypertension by reducing TRPM7 expression and carotid sinus nerve activity.

Shin, M. K., Roy, A., Paudel, O. + 4 more2026-03-07❤️ physiology

Human milk bacteria assembled into functionally distinct synthetic communities in infant formula differently affect intestinal physiology and microbiota in neonatal mini-piglets

This study demonstrates that supplementing infant formula with two distinct synthetic communities of human milk bacteria, characterized by different immunomodulatory properties, differentially alters gut microbiota composition and intestinal immune and barrier functions in neonatal mini-piglets compared to unsupplemented formula.

Le Bras, C., Randuineau, G., Cahu, A. + 11 more2026-03-06❤️ physiology

Circadian phase and sex shape swimming exercise responses and stereotyped behaviors in mice

This study demonstrates that circadian phase and sex interact to differentially modulate swimming behaviors, physiological stress responses, and post-exercise emotional outcomes in mice, highlighting the critical need to account for these factors in preclinical exercise research.

Cortes Soto, M. D., Wang, C., Kang, E. + 5 more2026-03-06❤️ physiology

The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney

This study reveals that aging-induced decline in kidney function is driven by the disruption of the MICOS complex, which leads to fragmented mitochondrial ultrastructure, metabolic dysregulation, and increased oxidative stress, ultimately exacerbating age-related kidney disease.

Katti, P., Prasad, P., Masenga, S. K. + 43 more2026-03-05❤️ physiology

Myosin binding protein-C limits strain induced cross-bridge detachment in response to rapid stretch in cardiac and skeletal muscle

This study demonstrates that while Myosin binding protein-C (MyBP-C) paralogs share common regulatory functions across muscle types, they exert unique, tissue-specific effects on cross-bridge kinetics—particularly in limiting strain-induced detachment during rapid stretch—to meet the distinct mechanical demands of cardiac and skeletal muscles.

Engels, N. M., Sadler, R. L., Kuehn, M. N. + 7 more2026-03-05❤️ physiology

Modern Times: Longitudinal Study of Toba/Qom Communities Reveals Delay and Shortening of Sleep in Real-Time

A longitudinal study of Toba/Qom communities in Argentina reveals that the introduction of electricity and digital technologies over a decade caused significant delays and shortening of sleep, suggesting that broader modernization processes, rather than light and devices alone, are driving these rapid behavioral shifts.

Casiraghi, L. P., Spiousas, I., Trebucq, L. L. + 6 more2026-03-04❤️ physiology

MATR3 is essential for oocyte growth and maturation quality through a dual molecular mechanism

This study demonstrates that the RNA-binding protein MATR3 is essential for oocyte growth and maturation quality by orchestrating transcription and paracrine signaling through a dual mechanism involving H3K9me2 demethylation and direct promoter binding, with its dysfunction leading to infertility and human oocyte maturation arrest.

Bao, Y., Zuo, Z., Wang, T. + 14 more2026-03-03❤️ physiology

Multiday rhythms modulate human heart rate: an observational study in healthy adults

This observational study of 623 healthy adults utilizing multi-year wearable data reveals that significant multiday (infradian) heart rate rhythms are prevalent in the general population, manifesting as distinct chronotypes influenced by environmental cycles and menstrual phases, thereby highlighting the need to investigate their mechanisms and clinical relevance beyond traditional circadian research.

De Silva, R., Stirling, R. E., Naim-Feil, J. + 3 more2026-03-03❤️ physiology

Improved Classification of Acute Physical Fatigue Using Salivary Proteomic Biomarkers: An Exploratory Study

This exploratory study demonstrates that an untargeted salivary proteomic panel outperforms targeted stress-related molecules in accurately classifying acute physical fatigue, suggesting a promising non-invasive approach for monitoring operational readiness in tactical athletes.

Lindsey, B., Bowden, K., Shaul, Y. + 6 more2026-03-02❤️ physiology

Altered metabolic health during pregnancy in mice with lean polycystic ovary syndrome-like traits from high prenatal AMH

This study demonstrates that while prenatal anti-Mullerian hormone exposure in Ins1-null mice induces mild reproductive PCOS-like traits without causing significant metabolic dysfunction, it does alter metabolic homeostasis during pregnancy by diminishing the insulinogenic response and reducing beta-cell mass, even as these mice maintain superior blood glucose control.

Houston, E. J., Jewett, E., Athar, F. + 1 more2026-03-02❤️ physiology

Diet- and metabolic state-dependent remodeling of the mouse brain lipidome

This study reveals that the mouse brain lipidome undergoes robust, reversible remodeling in response to fasting and refeeding, a process significantly altered by long-term high-fat diet intervention, thereby highlighting specific lipid species like linoleic acid-containing phosphatidylcholines as key regulators of metabolic adaptation in the hypothalamus and brainstem.

Bernard, A., Huynh, K., Fach, J. X. + 7 more2026-03-02❤️ physiology

Computational modelling of natural cell-to-cell heterogeneity reveals key parameters that control the diversity of human pancreatic islet β-cell excitability in response to glucose

By integrating high-volume single-cell electrophysiology data with computational modeling, this study reveals that natural heterogeneity in ion channel properties, particularly Na+ channel voltage dependence and ATP-sensitive K+ channel conductance, critically governs the diverse electrical phenotypes and glucose responsiveness of human pancreatic β-cells.

Goswami, I., Koepke, J., Baghelani, M. + 4 more2026-03-02❤️ physiology

Uromodulin promotes immune zonation and inhibits alternative inflammasome-mediated activation of immune-to-collecting duct inflammatory signaling in early acute kidney injury

This study demonstrates that uromodulin protects against early acute kidney injury by spatially confining immune interactions to the inner stripe and inhibiting Nlrc4-dependent inflammasome activation in macrophages, thereby preventing the induction of a proinflammatory phenotype in collecting duct cells.

Sabo, A., Nanamatsu, A., Wischmeier, D. + 6 more2026-03-01❤️ physiology

A Translational Model of MASLD-Associated HFpEF Defines Mitochondrial Dysfunction and Cardiac Plasticity During Disease Progression and Regression

This study establishes the Alms1-/- (Foz/Foz) mouse model as a robust translational platform demonstrating that mitochondrial dysfunction and fibroinflammatory remodeling drive MASLD-associated HFpEF, a condition characterized by reversible cardiac and hepatic phenotypes upon dietary intervention.

Ganguly, S., Gunes, B., Gu, Y. + 10 more2026-02-28❤️ physiology

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