137 papers
Physiology explores how living systems function, from the microscopic signals inside a single cell to the complex rhythms of an entire organism. This field seeks to understand the mechanical, physical, and biochemical processes that keep life moving, offering crucial insights into health, disease, and the body's remarkable ability to adapt.
On Gist.Science, we process every new preprint in this category from bioRxiv to make these rapid discoveries accessible to everyone. For each study, we provide both a clear, plain-language explanation and a detailed technical summary, ensuring that whether you are a curious student or a seasoned researcher, you can grasp the latest findings without getting lost in jargon.
The papers listed below represent the newest physiological research recently shared on bioRxiv, ready for you to explore.
This study demonstrates that beta cell glucocorticoid receptor signaling is essential for maintaining glucose homeostasis during glucocorticoid rhythm disruption by enabling compensatory hyperinsulinemia through the reprogramming of beta cell stimulus-secretion coupling.
This study demonstrates that administering a fixed dose of anomer-equilibrated streptozotocin to high-fat diet-fed C57BL/6J mice induces a stable, low-variability type 2 diabetes-like phenotype, offering a superior alternative to conventional weight-adjusted dosing which often leads to inconsistent outcomes and high mortality.
This study utilizes RNA sequencing in adult female *Drosophila* to demonstrate that the Estrogen-related receptor (ERR) regulates sex-specific transcriptional programs, including the downregulation of DNA replication machinery and the upregulation of ribosome biogenesis, alongside conserved metabolic pathways.
This study identifies PIEZO1-mediated mechanosensation in bladder smooth muscle as a key driver of age-related bladder dysfunction and demonstrates that targeting this pathway, either through genetic deletion or dietary inhibition with margaric acid, can alleviate urinary symptoms in aged mice while human genetic data links PIEZO1 gain-of-function variants to early-onset bladder dysfunction.
This study reveals that during glycosuria, a kidney-driven metabolic reprogramming coordinates skeletal muscle mannose oxidation and glutamine utilization to spare glucose and maintain systemic homeostasis, thereby limiting the glucose-lowering efficacy of SGLT2 inhibitors.
This study establishes a clinically relevant neonatal rat peritonitis model induced by fecal slurry and introduces a novel neonatal rat sepsis score (nRSS) that effectively correlates with disease severity, time course, and biochemical markers to facilitate future research on neonatal sepsis mechanisms and therapies.
Maternal iron deficiency induces significant remodeling of cardiac mitochondrial ultrastructure and selectively impairs iron-dependent respiration in hypertensive pregnancy, revealing a complex interplay where favorable hemodynamic adaptations coexist with underlying bioenergetic constraints despite the absence of overt oxidative damage or apoptosis.
This study identifies the gut microbiota-derived metabolite indole-3-propionic acid (IPA) as a direct regulator of hepatic glucose homeostasis that improves systemic glucose tolerance by remodeling mitochondrial metabolism and redirecting lactate-derived carbon away from gluconeogenesis, independent of classical insulin or glucagon signaling.
This study demonstrates that the physiological activation of TREK/TRAAK K2P channels occurs via a default down-to-up conformational transition driven by factors like intracellular acidification and regulatory lipids, rather than through a lipid-occluded pore mechanism.
This study demonstrates that while one year of dietary glucose supplementation significantly increases mortality in captive zebra finches compared to methylglyoxal supplementation, the underlying cause of this glucose-induced lethality remains unresolved despite similar levels of advanced glycation end-product (AGE) accumulation in both groups.