157 papers
This study establishes the Alms1-/- (Foz/Foz) mouse model as a robust translational platform demonstrating that mitochondrial dysfunction and fibroinflammatory remodeling drive MASLD-associated HFpEF, a condition characterized by reversible cardiac and hepatic phenotypes upon dietary intervention.
This study reveals that the mouse trachea exhibits distinct regional functional differences, with the distal section showing higher bicarbonate and chloride secretion and responsiveness to interleukins, while the proximal section demonstrates greater cAMP- and succinate-induced anion secretion but remains unresponsive to interleukin treatment.
This study demonstrates that TAK1 is a critical regulator of skeletal muscle mass, hypertrophic signaling, and metabolic homeostasis in both male and female mice, where its inactivation leads to rapid atrophy in males, blocks hypertrophy in both sexes, and disrupts gene expression and fatty acid oxidation.
This study demonstrates that a high-fat, high-salt diet induces an early metabolic dysfunction-associated kidney disease (MDAKD) phenotype in C57BL/6 mice characterized by strain-specific functional responses, tubular injury, and fibrosis, driven primarily by diet-induced mitochondrial bioenergetic uncoupling that impairs ATP synthesis efficiency without causing obesity.
This study demonstrates that neuronal ketone body utilization is essential, while hepatic ketone production is contributory, for the cognitive and synaptic benefits of combining exercise with time-restricted feeding in middle-aged mice.
This study establishes a causal link between glyphosate exposure and hypertension, demonstrating that the herbicide disrupts gut-liver and gut-vascular homeostasis via FXR signaling and shikimic acid accumulation, thereby elevating blood pressure through gut microbiota-mediated mechanisms.
This study demonstrates that the Hallers organ is critical for humidity sensing in American dog ticks, as its impairment prevents necessary water vapor uptake, leading to dehydration, energy depletion, and significantly reduced survival under variable environmental conditions.
This study demonstrates that in *Manduca sexta* hawkmoths, the circadian regulation of pheromone-sensitive olfactory receptor neurons is driven not by the canonical transcriptional-translational feedback loop, but by a rapid post-translational feedback loop involving the cAMP-dependent modulation of the Orco ion channel's conductivity.
This study reveals that age-related downregulation of brown adipose tissue (BAT) ADH5, driven by HSF1 suppression, exacerbates metabolic and cognitive decline, while pharmacological restoration of the HSF1-ADH5 signaling cascade mitigates these aging-associated dysfunctions.
This study demonstrates that interpersonal respiratory synchronization during social interaction strengthens self-other coupling but simultaneously disrupts intrapersonal cardiorespiratory coordination, revealing a physiological trade-off where aligning rhythms with others weakens the phase relationship between one's own heart and breathing.
This longitudinal study of collaborative drawing programs found that while interpersonal distance and self-reported closeness effectively characterized relationship development in both intergenerational and same-generation dyads, cardiac synchrony showed only a marginal link to active collaboration specifically within intergenerational pairs.
This study establishes the feasibility of applying high-resolution spatial transcriptomics to intra-operative human skeletal muscle biopsies to define fiber-type-specific gene expression signatures associated with neuromuscular degeneration and regeneration following peripheral nerve injury.
This study demonstrates that formate supplementation protects male hearts from ischemia/reperfusion injury by preserving tetrahydrobiopterin levels and enhancing nitric oxide synthase-dependent protein S-nitrosation.
This study reveals that while heterozygous loss of Brca1 causes sexually dimorphic systemic metabolic effects—promoting obesity and insulin resistance in females but conferring modest protection in males—it universally exacerbates high-fat diet-induced hepatic steatosis in both sexes, a condition that can be ameliorated by tirzepatide treatment in females.
This study demonstrates that *Mytilus galloprovincialis* possesses a functional circadian clock that endogenously regulates shell biomineralisation rhythms through a complex, indirect mechanism involving co-localized but differently phased gene expression in the mantle.
In resistance-trained individuals, a large, abrupt 120% increase in weekly resistance training volume does not impair skeletal muscle hypertrophy or significantly alter anabolic-catabolic molecular signaling compared to a modest 20% increase.
This study provides the first comprehensive spatial mapping of the human palm, revealing that tactile and pain sensitivities are inversely correlated, with fingertips being more touch-sensitive but less pain-sensitive than proximal areas, and that sensitivity is generally higher in the non-dominant hand and in women.
Combination therapy with Sclerostin and Dkk1 antibodies synergizes with mechanical tibial loading to significantly enhance periosteal bone formation and improve bone morphology in aged mice, suggesting a promising dual-targeted approach for treating age-related osteoporosis.
This study demonstrates that a single dose of mesenchymal stromal cell-derived regenerative extracellular matrix (rECM) accelerates diabetic wound healing by coordinating enhanced peripheral nerve formation, vascular maturation, and granulation tissue remodeling.
This study reveals that sex-specific differences in atrial electrophysiology and cholinergic responses, driven by variations in gene expression and regional heterogeneity, underlie distinct mechanisms of arrhythmia vulnerability in healthy rabbit hearts.