157 papers
This study proposes that cardiac PIEZO 1 channels mediate both conscious and subconscious cardiac interoception, where reduced channel sensitivity disrupts predictive coding of heart signals to cause anxiety, while enhanced sensitivity improves anxiety outcomes and cardiovascular health.
This study integrates phosphoproteomics of human hypertrophic cardiomyopathy (HCM) myocardium with hiPSC-CM modeling to demonstrate that altered microtubule dynamics in HCM are driven not by changes in modifying enzyme levels, but by Protein Kinase A-mediated regulation of microtubule repolymerization in response to beta-adrenergic stimulation.
This study challenges the paradigm that mechanosensation is solely a plasma membrane phenomenon by revealing a novel intracellular mechanism in intestinal smooth muscle where a nanoscale Piezo1-RyR-BKCa complex on the sarcoplasmic reticulum detects mechanical stress to trigger calcium release and membrane hyperpolarization, thereby acting as a critical gain-control brake on contractility and GI motility.
Using cryo-electron tomography on a claudin-deficient epithelial model expressing only CLDN15, this study provides the first direct visualization of paracellular pores within tight junctions, confirming their structural organization and dimensions as predicted by previous models.
This study reveals that hibernating frogs can temporarily abandon glucose metabolism by upregulating the local production of ketone bodies within the brain to sustain neural activity and synaptic transmission during severe hypoxia and hypoglycemia.
This study presents a dataset demonstrating that placental-targeted overexpression of Insulin-like growth factor 1 (IGF1) in mice leads to sexually dimorphic increases in adult heart and liver mass, whereas IGF1 insufficiency results in no significant changes, thereby highlighting the critical role of placental IGF1 in long-term organ development.
This study identifies the natural xanthone -Mangostin as a potent vasorelaxant that activates BK channels by binding to specific gating residues (I308, L312, and A316) in the S6 domain, thereby stabilizing the open state and shifting voltage activation to more negative potentials.
This study demonstrates that rapid humidity ramp protocols systematically underestimate human heat tolerance limits due to thermal disequilibrium, whereas protocols incorporating prolonged dwell times (≥60 minutes per step) allow for near-equilibrium conditions and yield significantly higher, more accurate critical environmental limits.
This study establishes that cardiomyocyte-specific, inducible impairment of Polymerase Gamma activity causes severe hypertrophic cardiomyopathy and associated hepatopathy in mice by driving mtDNA instability, which triggers chronic integrated stress response activation and rewiring of mitochondrial folate metabolism.
This study reveals that the redox-signaling enzyme NOX4 induces a Warburg-type metabolic reprogramming in the adult heart by activating NRF2 and ATF4 transcription factors and epigenetic mechanisms, thereby balancing increased energy demands with the anabolic needs required for cardiac hypertrophy.
This study demonstrates that the loss of cardiomyocyte-specific eEF1A2 triggers cardiomyopathy by impairing protein folding and autophagy, leading to proteostasis failure that can be rescued by mTORC1 inhibition.
This study demonstrates that a regionally inspired West Virginia Obesogenic Diet (WV-OD) effectively induces obesity and metabolic dysfunction in male mice comparable to high-fat diets, while revealing significant sex disparities as females on the same diet did not exhibit similar fat accretion or metabolic issues.
This study demonstrates that the radial atrophy of skeletal muscle fibers caused by aging and disuse is primarily driven by a reduction in the number of myofibrils rather than a decrease in their individual size, a mechanism that is conserved across species and conditions despite some context-dependent variations.
This study demonstrates that the adrenal gland, rather than the hypothalamus or pituitary, is the primary site of persistent dysfunction limiting HPA axis recovery after chronic glucocorticoid treatment, as evidenced by prolonged corticosterone suppression despite rapid central axis rebound and the failure of exogenous ACTH to prevent adrenal atrophy.
This study reveals that the Strehler-Mildvan mortality correlation arises from changes in the variability of ageing, demonstrating that rectangularization and triangularization of survival curves result from distinct patterns of healthspan and morbidity expansion that are evolutionarily conserved across species.
This study demonstrates that while cardiac ageing in mice preserves total lysosomal abundance and acidification capacity as measured by IVIS Lysotracker imaging and key gene expression, it may induce a slight increase in autophagic demand indicated by upregulated Sqstm1, highlighting the value of combining whole-organ imaging with molecular analysis to assess cardiac proteostasis.
This paper demonstrates that tree crickets achieve precise sound localization by utilizing a biomechanical interferometer that splits sound waves between anterior and posterior tympanic membranes, recombining them at the tracheal wall to convert microsecond time delays into measurable mechanical strain.