109 papers
Physiology explores how living systems function, from the microscopic signals inside a single cell to the complex rhythms of an entire organism. This field seeks to understand the mechanical, physical, and biochemical processes that keep life moving, offering crucial insights into health, disease, and the body's remarkable ability to adapt.
On Gist.Science, we process every new preprint in this category from bioRxiv to make these rapid discoveries accessible to everyone. For each study, we provide both a clear, plain-language explanation and a detailed technical summary, ensuring that whether you are a curious student or a seasoned researcher, you can grasp the latest findings without getting lost in jargon.
The papers listed below represent the newest physiological research recently shared on bioRxiv, ready for you to explore.
This study utilizes multi-omics profiling of a pig model to characterize the cellular and molecular landscape of progressive right ventricular dysfunction, identifying specific mechanisms such as impaired mitochondrial proteostasis, defective macrophage efferocytosis, and activated ribotoxic stress responses as potential therapeutic targets.
This study identifies chitinase 3-like 1 (Chi3l1) as a critical metabolic regulator that selectively protects embryo-derived Kupffer cells from stress-induced death by inhibiting glucose uptake, thereby preventing their replacement by inflammatory monocyte-derived macrophages and mitigating the progression of metabolic dysfunction-associated steatotic liver disease (MASLD).
Aerobic swimming exercise alleviates hypertension and cardiac dysfunction in spontaneously hypertensive rats by inhibiting myocardial glycation and suppressing the AGEs/RAGE-p38 MAPK-NF-κB signaling pathway.
This study identifies a loss-of-function variant in the GFRAL receptor that is associated with increased alcohol consumption in humans and demonstrates that GDF15 acts as an endocrine signal induced by alcohol exposure to suppress intake, suggesting a natural mechanism for limiting alcohol consumption.
Five days of isothermic heat acclimation enhances cardiovascular and thermoregulatory performance in endurance athletes by lowering resting heart rate, expanding plasma volume, and increasing sweat loss, yet it fails to mitigate renal tubular stress, fluid-regulatory strain, or sympathetic activity during subsequent exercise in hot, humid conditions.
This study reveals that in temperate pine forests, seasonal carbon balance is primarily driven by the rapid redistribution of soluble sugars rather than significant fluctuations in overall non-structural carbon storage, as evidenced by year-round measurements showing sugars account for the majority of annual flux while starch and lipids play more stable or secondary roles.
Loss of bone marrow β1/β2-adrenergic receptors protects mice against diet-induced obesity by reprogramming the gut microbiota to enrich Bacteroidetes, which reduces dietary lipid absorption and alters fecal lipid profiles.
This study demonstrates that circadian phase and sex interact to differentially modulate swimming behaviors, physiological stress responses, and post-exercise emotional outcomes in mice, highlighting the critical need to account for these factors in preclinical exercise research.
This study demonstrates that the RNA-binding protein MATR3 is essential for oocyte growth and maturation quality by orchestrating transcription and paracrine signaling through a dual mechanism involving H3K9me2 demethylation and direct promoter binding, with its dysfunction leading to infertility and human oocyte maturation arrest.
This exploratory study demonstrates that an untargeted salivary proteomic panel outperforms targeted stress-related molecules in accurately classifying acute physical fatigue, suggesting a promising non-invasive approach for monitoring operational readiness in tactical athletes.