109 papers
Physiology explores how living systems function, from the microscopic signals inside a single cell to the complex rhythms of an entire organism. This field seeks to understand the mechanical, physical, and biochemical processes that keep life moving, offering crucial insights into health, disease, and the body's remarkable ability to adapt.
On Gist.Science, we process every new preprint in this category from bioRxiv to make these rapid discoveries accessible to everyone. For each study, we provide both a clear, plain-language explanation and a detailed technical summary, ensuring that whether you are a curious student or a seasoned researcher, you can grasp the latest findings without getting lost in jargon.
The papers listed below represent the newest physiological research recently shared on bioRxiv, ready for you to explore.
This study establishes the Alms1-/- (Foz/Foz) mouse model as a robust translational platform demonstrating that mitochondrial dysfunction and fibroinflammatory remodeling drive MASLD-associated HFpEF, a condition characterized by reversible cardiac and hepatic phenotypes upon dietary intervention.
This study reveals that age-related downregulation of brown adipose tissue (BAT) ADH5, driven by HSF1 suppression, exacerbates metabolic and cognitive decline, while pharmacological restoration of the HSF1-ADH5 signaling cascade mitigates these aging-associated dysfunctions.
This longitudinal study of collaborative drawing programs found that while interpersonal distance and self-reported closeness effectively characterized relationship development in both intergenerational and same-generation dyads, cardiac synchrony showed only a marginal link to active collaboration specifically within intergenerational pairs.
This study demonstrates that *Mytilus galloprovincialis* possesses a functional circadian clock that endogenously regulates shell biomineralisation rhythms through a complex, indirect mechanism involving co-localized but differently phased gene expression in the mantle.
This study reveals that the Strehler-Mildvan mortality correlation arises from changes in the variability of ageing, demonstrating that rectangularization and triangularization of survival curves result from distinct patterns of healthspan and morbidity expansion that are evolutionarily conserved across species.
This study demonstrates that while cardiac ageing in mice preserves total lysosomal abundance and acidification capacity as measured by IVIS Lysotracker imaging and key gene expression, it may induce a slight increase in autophagic demand indicated by upregulated Sqstm1, highlighting the value of combining whole-organ imaging with molecular analysis to assess cardiac proteostasis.
This paper demonstrates that tree crickets achieve precise sound localization by utilizing a biomechanical interferometer that splits sound waves between anterior and posterior tympanic membranes, recombining them at the tracheal wall to convert microsecond time delays into measurable mechanical strain.
This study characterizes the transcriptomic profiles of migrating pink salmon across three critical tissues, revealing that major molecular changes occur primarily around spawning and are marked by coordinated catabolic processes, immune activation, and lipid mobilization orchestrated by dominant endocrine receptor ohnologs.
This study demonstrates for the first time that *Geobacter sulfurreducens* can oxidize propionate via the methylmalonyl-CoA pathway, but only when fumarate or acetate is present as a specific electron acceptor or co-substrate, highlighting the electron acceptor-dependent nature of this metabolic capability.
While testosterone significantly reduces allergic lung inflammation induced by house dust mites in mice, it simultaneously increases airway smooth muscle responsiveness to methacholine, suggesting a complex role in asthma pathophysiology.