🩺 Category

dermatology

15 papers

Efficacy, safety and dose response of STS01, a topical controlled release nanoparticle formulation (dithranol/Prosilic), in adults with mild to moderate patchy alopecia areata: A randomised, double-blind, multicentre, phase 2 trial

In a randomized, double-blind, phase 2 trial involving 155 adults with mild to moderate patchy alopecia areata, the topical nanoparticle formulation STS01 demonstrated a clear dose-response relationship, with the 1% concentration significantly outperforming placebo in hair regrowth efficacy while maintaining a manageable safety profile characterized primarily by mild to moderate skin irritation.

Fleet, D., Messenger, A., Bryden, A. + 12 more2026-04-04🩺 dermatology

Health-related quality of life in mild-moderate patchy alopecia areata: Results from the first controlled Phase 2 clinical trial in this population with STS01 (dithranol/ProSilic) and challenges for the future

Although the Phase 2 trial of STS01 demonstrated significant, dose-dependent hair regrowth in patients with mild-to-moderate patchy alopecia areata, these physical improvements did not translate into statistically significant gains in health-related quality of life, highlighting challenges in measuring patient-reported outcomes due to factors like the lack of a true baseline, coping mechanisms, and delays between physical and psychological recovery.

Fleet, D. M., Messenger, A., Bryden, A. + 12 more2026-04-04🩺 dermatology

Pixaire1: Evaluation of automated chronic wound surface measurement systems.

This study evaluates two smartphone-based wound measurement systems, finding that the semi-automated Woundtrack method offers accuracy and precision comparable to the reference digitized planimetry and is highly effective for clinical use, while the fully automated Woundsize method, though generally reliable, shows greater discrepancies in small wounds and is best implemented with clinician validation.

Maxant, G., Mori, C., Maxant, T. + 1 more2026-03-31🩺 dermatology

Grading of Erythema and Visual Attributes in Atopic Dermatitis across Diverse Skin Tones Using a Vision AI Pipeline

This study developed and validated a two-stage Vision AI pipeline using EfficientNet CNNs and texture analysis features that achieves dermatologist-level accuracy in grading erythema and moderate agreement for excoriation and lichenification in atopic dermatitis, demonstrating particular potential for objectively assessing erythema across diverse skin tones where human raters often struggle.

Abdolahnejad, M., Kyremeh, M., Smith, J. + 4 more2026-03-31🩺 dermatology

Patient Perspectives and Satisfaction: Educational Needs and Communication Barriers in Dermatology Clinics in Saudi Arabia - A Cross-Sectional Survey

This cross-sectional survey of 976 dermatology patients in Saudi Arabia reveals moderate overall satisfaction alongside significant educational gaps and communication barriers, highlighting the need for longer consultations, supportive environments, and Arabic-language, face-to-face educational strategies to improve patient understanding and care quality.

Alshammarie, F., Alhobera, A., Alshammari, M.2026-03-12🩺 dermatology

Copy Number Analysis in Congenital Nevi: Concordance and Diagnostic Limitations of aCGH, sWGS, and Methylation Profiling

This study demonstrates that while high-resolution platforms like shallow whole-genome sequencing and methylation arrays detect more focal copy number alterations than traditional aCGH in congenital nevi nodules, their discordance with established aCGH-based criteria necessitates the continued use of aCGH as the most conservative and clinically validated method for risk stratification until platform-specific diagnostic thresholds are developed.

Karelin, A., Brecht, I. B., Pogoda, M. + 8 more2026-03-05🩺 dermatology

Multi-criterion uncertainty estimation improves skin cancer distribution shift detection and malignancy prediction

This paper introduces Supervised Autoencoders for Generalization Estimates (SAGE), a multi-criterion uncertainty estimation method that effectively detects distribution shifts in skin lesion images across diverse global datasets, thereby improving the reliability of malignancy prediction models by filtering out problematic artifacts before clinical deployment.

Schreyer, W. M., Samathan, R., Berry, E. + 1 more2026-02-27🩺 dermatology

Behavioral and Healthcare Determinants of Self-Reported Scabies in Chiwanda Ward, Nyasa District, Tanzania

This retrospective study in Nyasa District, Tanzania, utilized a mixed-methods approach to reveal that household scabies transmission is significantly driven by the sharing of personal items and treatment access barriers, underscoring the need for coordinated public health responses that combine household-level prevention, improved treatment availability, and stronger community-health system engagement.

Kilagwa, I. T., William, R. N., Mwabukusi, M. + 4 more2026-02-27🩺 dermatology

Knowledge, Attitudes, and Practices (KAP) Regarding Photoprotection Among Medical Students at a Nicaraguan University: A Cross-Sectional Study

This cross-sectional study of 133 medical students in Nicaragua reveals a significant gap between their high theoretical knowledge and low practical adherence to photoprotection, highlighting the need for enhanced, behavior-oriented education in medical curricula to improve future skin cancer prevention counseling.

Montes, J., Noguera, B., Obregon, A. + 4 more2026-02-26🩺 dermatology

Diagnostic accuracy of two-photon fluorescence microscopy in the Mohs micrographic surgical margins of squamous cell carcinoma

This study demonstrates that two-photon fluorescence microscopy (TPFM) offers a rapid, accurate, and reliable alternative to conventional frozen section analysis for evaluating squamous cell carcinoma margins in Mohs micrographic surgery, achieving high sensitivity and specificity with minimal training.

Huang, C. Z., Ching-Roa, V. D., Heckman, C. M. + 5 more2026-02-24🩺 dermatology

Methicillin-Susceptible Staphylococcus aureus ST398 in atopic dermatitis in Portugal displays pathogenic traits associated with impaired skin barrier function

This study reveals that methicillin-susceptible *Staphylococcus aureus* ST398, a prevalent community lineage in Portugal, is the dominant strain colonizing atopic dermatitis lesions in adult patients, where it exhibits specific pathogenic traits like hemolysin and urease production that likely facilitate its adaptation to the impaired skin barrier.

Caieiro, D., Faria, N. A., Botelho, A. + 5 more2026-02-18🩺 dermatology