788 papers
This study reveals that human body temperature (37°C) enhances azole tolerance in *Candida albicans* by inducing mitochondrial dysfunction and reactive oxygen species accumulation, which inhibits autophagy-mediated degradation of the drug target Erg11, thereby preserving its levels and reducing antifungal efficacy.
This study optimized and applied a BONCAT-FACS workflow to IODP 385 Guaymas Basin sediments, revealing that heterotrophic Gammaproteobacteria, Bacilli, Deinococci, and Alphaproteobacteria remain translationally active down to 154 meters below the seafloor and utilize C1 metabolism, carbohydrate degradation, and fermentation to drive organic matter cycling in the deep biosphere.
By integrating NMR, cryo-EM, and mutational analyses of the highly similar major pilins from *Dickeya dadantii* and *Klebsiella oxytoca*, this study reveals how subtle sequence variations in conserved type II secretion system endopili dictate their assembly, stability, and functional specificity across different ecological niches.
This study characterizes the developmental dynamics and core structure of the *Eugenia uniflora* phyllosphere bacterial community, revealing significant shifts in diversity and functional potential between young and mature trees while identifying a conserved core microbiome across the Myrtaceae family.
This study identifies the *gacSA* two-component system in *Pseudomonas protegens* Pf-5 as a central sensory hub that integrates physical flagellar cues and chemical root signals to activate cyclic di-GMP-mediated attachment programs, thereby enabling the bacterium's transition from a planktonic state to successful root colonization.
This study demonstrates that Corynebacterium bovis alone causes hyperkeratosis in immunocompromised mice, but disease severity is significantly modulated by host genetics and, most notably, by the presence of specific protective microbiome constituents that can prevent clinical lesions.
This study demonstrates that the freshwater anaerobic methanotroph 'Ca. Methanoperedens vercellensis' can adapt to low pH environments (down to 5.65) through membrane lipid remodelling, specifically by increasing zwitterionic lipids, thereby maintaining its role in the biological methane filter despite increased energy demands.
This study utilized shotgun metagenomics to characterize household bacterial microbiomes across ten homes in Mysuru, Dubai, and Tucson, revealing significant variations in diversity driven by geographic location and cultural practices, while identifying a global core microbiome dominated by human-associated phyla.
This study reveals that sub-minimal inhibitory concentration exposures to copper and silver elicit distinct kill kinetics in *Escherichia coli*, with copper causing sustained growth inhibition while silver induces transient killing followed by regrowth, highlighting the limitations of standard non-kinetic assays in assessing metal-based antimicrobial risks.
This study demonstrates that the master regulator SsrB of Salmonella's SPI-2 virulence system imposes environment-specific growth and fitness costs independent of the Type 3 Secretion System itself, thereby providing a mechanistic basis for the observed heterogeneous expression of SPI-2.
This study demonstrates that in *Cupriavidus necator*, asymmetric single-cell inheritance of polyhydroxybutyrate (PHB) storage granules confers a conditional fitness advantage by extending proliferation during carbon starvation and accelerating recovery from nitrogen starvation, thereby explaining the evolutionary persistence of carbon storage in fluctuating environments despite its lack of benefit during nutrient abundance.
This study reveals that carbapenem resistance in a Nigerian ICU is driven by the horizontal spread of a conserved mobile resistance island carrying *bla*NDM-5 across diverse *Enterobacter hormaechei* and *Klebsiella pneumoniae* strains, highlighting the critical need to track mobile genetic elements alongside bacterial lineages for effective infection control in low-resource settings.
This study demonstrates that the virtual colony count assay reveals a pronounced inoculum effect of the antimicrobial peptide HNP1 against *Staphylococcus aureus* ATCC 29213, which is associated with biofilm formation as a resistance mechanism.
By integrating dilution-to-extinction microbiome perturbation with genome-resolved synthetic ecology, this study successfully reconstructed a bacterial consortium from disease-suppressive soil that protects wheat against *Fusarium culmorum* by producing novel NAPAA compounds.
This study compared antibiotic resistance genes, virulence factors, and pathogen profiles across households in Mysuru, Dubai, and Tucson, revealing significant geographic variations in resistance and viral diversity while identifying a core set of resistance genes present in all locations.
This study reveals that intrinsically disordered regions in elicitin-like effectors from the biotrophic oomycete *Albugo candida* function as molecular shields to evade host immune recognition, a mechanism that can be transferred to other effectors to suppress plant immunity.
This study demonstrates that extracellular vesicles secreted by a polymicrobial community of CF lung pathogens exacerbate innate immune responses and inhibit CFTR function in cystic fibrosis epithelial cells, explaining why highly effective modulator therapies like Trikafta fail to eliminate chronic infections or restore normal lung physiology.
The paper introduces PALM, a fast and reliable quasi-Poisson regression framework designed to improve false discovery control, statistical power, and computational efficiency in large-scale microbiome association studies and meta-analyses.
This study confirms that *Pleurotus ostreatus* cultivated on Nigerian agro-waste substrates (Gmelina sawdust, oil palm fiber, and cassava peels) yields bioactive extracts with significant antifungal and antioxidant properties, demonstrating that substrate choice substantially influences the mushroom's therapeutic potential.
This study reveals that in cyanobacteria, polyphosphate acts as a conserved architectural regulator that spatially organizes the nucleoid and carboxysomes to couple chromosome structure with metabolic compartmentalization and photosynthetic fitness.